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Etiopathogenic role of surfactant protein d in the clinical and immunological expression of primary Sjögren syndrome.

J Rheumatol

January 2015

From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.

Objective: To analyze the etiopathogenic role of genetic polymorphisms and serum levels of surfactant protein-D (SP-D) in primary Sjögren syndrome (pSS).

Methods: We analyzed 210 consecutive patients with pSS. SFTPD genotyping (M11T polymorphism rs721917) was analyzed by sequence-based typing and serum SP-D by ELISA.

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