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Blockade of supraspinal 5-HT1A receptors potentiates the inhibitory effect of venlafaxine on wind-up activity in mononeuropathic rats.
Brain Res
May 2004
E 9904 INSERM/UdA, Laboratory of Medical Pharmacology, Faculty of Medicine, University of Auvergne-1, Clermont-Ferrand, France.
Article Synopsis
- In a study with mononeuropathic rats, repeated injections of 10 mg/kg venlafaxine led to a significant decrease in spinal wind-up responses, while 2.5 mg/kg did not show this effect.
- The findings suggest that venlafaxine, which inhibits serotonin reuptake, effectively reduces pain-related responses in these rats.
- Additionally, using the 5-HT1A receptor antagonist WAY 100,635 alongside venlafaxine enhanced its pain-reducing effects, indicating a potential pathway for improving treatment outcomes.