Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents targeting XIAP protein.

X-linked inhibitor of apoptosis protein (XIAP) is a member of inhibitor of apoptosis protein (IAP) family responsible for neutralizing the caspases-3, caspases-7, and caspases-9. Overexpression of the protein decreased the apoptosis process in the cell and resulting development of cancer. Different types of XIAP antagonists are generally used to repair the defective apoptosis process that can eliminate carcinoma from living bodies.

Intensified constructed wetlands for the treatment of municipal wastewater: experimental investigation and kinetic modelling.

This study reports organics and nutrient removal performances of the intensified constructed wetlands, i.e., tidal flow-based microbial fuel cell (MFC) and tidal flow wetlands that received municipal wastewater.

Immunoglobulins content in colostrum, transitional and mature milk of Bangladeshi mothers: Influence of parity and sociodemographic characteristics.

Background: The study investigated the concentration of IgA, IgM and IgG in colostrum, transitional and mature milk and the effect of parity, age, BMI and family income on secreted immunoglobulin contents of human milk.

Methods: Sequential samples of colostrum, transitional and mature milk were collected from 38 women. Enzymelinked immunosorbent assay was used to analyse the immunoglobulin concentrations.

Evaluation of Serum Lysophosphatidic Acid and Lysophosphatidylcholine Levels in Major Depressive Disorder Patients.

Background Major depressive disorder (MDD) is a heterogeneous condition featured with a continuous low mood, feeling of sadness, lack of interest to perform daily activities. Genetic, physiological, biological, social, and environmental factors are associated with the pathophysiology of depression. Though several human studies failed to identify the suitable biological markers for depression, some animal studies showed phospholipids play a vital role in the alteration of emotion.

The rs11615, rs2276466, rs2228000 and rs2228001 polymorphisms increase the cervical cancer risk and aggressiveness in the Bangladeshi population.

Background: Multiple studies around the world revealed that genetic polymorphism in different genes of the DNA repair system might affect the DNA repair capabilities and accelerate the chances of cervical cancer (CC) development. Therefore, we aimed to evaluate the association of DNA repair gene- rs11615, rs2276466, rs2228000 and rs2228001 polymorphisms and CC susceptibility in the Bangladeshi population.

Methods: A case-control genetic association study was conducted among 210 patients with diagnostically confirmed CC and 200 healthy volunteers.

SARS-CoV-2 pandemic-induced PPE and single-use plastic waste generation scenario.

The SARS-CoV-2 pandemic has demonstrated both positive and negative effects on the environment. Major concerns over personal hygiene, mandated and ease in lockdown actions and slackening of some policy measures have led to a massive surge in the use of disposable personal protective equipment (PPE) and other single-use plastic items. This generated an enormous amount of plastic waste from both healthcare and household units, and will continue to do so for the foreseeable future.

An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode.

The facile wet-chemical technique was used to prepare the low-dimensional nano-formulated porous mixed metal oxide nanomaterials (CuO.MnO.NiO; CMNO NMs) in an alkaline medium at low temperature.

Advances in immunotherapy for the treatment of spinal cord injury.

Spinal cord injury (SCI) is a leading cause of morbidity and disability in the world. Over the past few decades, the exact molecular mechanisms describing secondary, persistent injuries, as well as primary and transient injuries, have attracted massive attention to the clinicians and researchers. Recent investigations have distinctly shown the critical roles of innate and adaptive immune responses in regulating sterile neuroinflammation and functional outcomes after SCI.

A Robust Feature Extraction Model for Human Activity Characterization Using 3-Axis Accelerometer and Gyroscope Data.

Human Activity Recognition (HAR) using embedded sensors in smartphones and smartwatch has gained popularity in extensive applications in health care monitoring of elderly people, security purpose, robotics, monitoring employees in the industry, and others. However, human behavior analysis using the accelerometer and gyroscope data are typically grounded on supervised classification techniques, where models are showing sub-optimal performance for qualitative and quantitative features. Considering this factor, this paper proposes an efficient and reduce dimension feature extraction model for human activity recognition.

Serum interferon-gamma level is associated with drug-naïve major depressive disorder.

Objectives: Major depressive disorder is a leading heterogeneous psychiatric illness manifested by persistent low mood, a feeling of sadness, and diminished interest in daily activities. Many biological, genetic, and social factors are thought to be linked with depression. But any suitable early risk assessment markers are absent for this illness.

Assessment of physico-chemical characteristics of river water emphasizing tannery industrial park: a case study of Dhaleshwari River, Bangladesh.

Pollution of industry-adjacent surface water bodies become a major environmental concern in Bangladesh recently. Therefore, this study aimed to elaborate assessment of physico-chemical characteristics of the Dhaleshwari River (the adjacent river of newly shifted tannery industrial park) and also the discharged effluent from the central effluent treatment plant (CETP) considering both seasonal and spatial variations. Among the examined 30 water quality parameters (including 11 heavy metals), only TDS, Cl, NO-N, EC, Cu, Zn, Cd, and Ni met the standards for discharged wastewater from industrial units into inland surface water set by Bangladesh government.

Fabrication of selective and sensitive chemical sensor probe based on ternary nano-formulated CuO/MnO/GdO spikes by hydrothermal approach.

In this approach, thin spikes (NSs) of ternary nano-formulated mixed CuO/MnO/GdO were synthesized by the hydrothermal approach for efficient detection of 3-methoxyphenyl hydrazine (3-MPHyd) chemical from various environmental samples. The NSs were systematically characterized by using XPS, EDS, TEM, FTIR, UV/vis, and XRD. The fabricated NSs onto the glassy carbon electrode (GCE) was successfully applied for the selective and sensitive detection of 3-MPHyd in the phosphate buffer system (PBS), which displayed the highest sensitivity, good selectivity with ultra-trace detection limit, high stability, good reproducibility, and quick response time.

Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder.

Major depressive disorder (MDD) is a debilitating psychiatric disease. The dysregulated cytokines in depression are assumed due to the hyperactivation of the immune system. Here we aimed to evaluate the serum interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in MDD.

Association of DRD2 gene polymorphisms with schizophrenia in the young Bangladeshi population: A pilot study.

Purpose: DRD2 gene is considered one of the most important candidate genes for the schizophrenia (SCZ) development due to its role in dopamine signaling and no genetic association study has been conducted yet on the Bangladeshi SCZ patients. The objective of the present study was to investigate the association of DRD2 genetic polymorphisms (rs4648317, rs4936270, and rs7131056) with SCZ in the Bangladeshi population.

Patients And Methods: This case-control study consisted of 101 SCZ patients and 101 controls.

Shear Response of Glass Fibre Reinforced Polymer (GFRP) Built-Up Hollow and Lightweight Concrete Filled Beams: An Experimental and Numerical Study.

This paper investigated the static behaviour of glass fibre reinforced polymer (GFRP) built-up hollow and concrete filled built-up beams tested under four-point bending with a span-to-depth ratio of 1.67, therefore focusing their shear performance. Two parameters considered for hollow sections were longitudinal web stiffener and strengthening at the web-flange junction.

Variants of SMAD1 gene increase the risk of colorectal cancer in the Bangladeshi population.

Colorectal cancer is the fourth most common type of malignancy worldwide that may develop due to the accumulation of several genetic variations. Different single nucleotide polymorphisms of SMAD1 gene are assumed to be linked with increased colorectal cancer risk. The current case-control study was conducted to verify the association of genetic polymorphisms of SMAD1 (rs11100883 and rs7661162) with colorectal cancer in the Bangladeshi population.

A Haemophilic Dengue Patient with Pleural Effusion and Earache.

About 2.5 billion people are living at a higher risk of dengue fever in hundreds of tropical and sub-tropical countries. Treatment of dengue fever is quite complicated and challenging because of the lack of effective treatment approaches.

Association Between REELIN Gene Polymorphisms (rs7341475 and rs262355) and Risk of Schizophrenia: an Updated Meta-analysis.

Schizophrenia (SCZ) is a destructive neuropsychiatric illness affecting millions of people worldwide. The correlation between RELN gene polymorphisms and SCZ was investigated by previous researches, though the results remained conflicting. Based on the available studies, we conducted this meta-analysis to provide a more comprehensive outcome on whether the RELN gene polymorphisms (rs7341475 and rs262355) are associated with SCZ.

Phenotypic dynamics in polyphosphate and glycogen accumulating organisms in response to varying influent C/P ratios in EBPR systems.

This study employed molecular tools and single cell Raman micro-spectroscopy techniques to reveal the single cell- and population-level phenotypic dynamics and changes in functionally relevant organisms, namely polyphosphate accumulating organisms (PAOs) and glycogen accumulating organisms (GAOs), in response to influent loading readily biodegradable carbon to phosphorus ratio (C/P) changes in enhanced biological phosphorus removal (EBPR) systems. The results, for the first time, provided direct and cellular evidence confirming the adaptive anaerobic metabolic pathway shifts in PAOs in response to influent loading variations. Increase in influent readily biodegradable carbon to phosphorus (C/P) ratio from 20 to 50 led to nearly 50% decline in polyphosphate content and drastic rise of intracellular polyβhydroxybutyrate (PHB) to polyphosphate (polyP) ratio by nearly 6 times in PAOs, indicating corresponding diminishing reliance on polyP hydrolysis for energy as P becomes limiting.

Effect of immunonutritional status, healthcare factors, and lifestyle on acute respiratory infections among under-5 children in Bangladesh.

Introduction: Acute respiratory infection is a major cause of death for under-5 children in Bangladesh. We aimed to analyze the effect of immunonutritional status, healthcare factors, and lifestyle on the incidence of acute respiratory infection among under-5 children taking individual-level and contextual-level risk factors into consideration.

Methods: This study recruited 200 children suffering from acute respiratory infection and 100 healthy controls matched by age, sex, and sociodemographic profile.

Advances in single cell Raman spectroscopy technologies for biological and environmental applications.

The increasing sophistication of single cell Raman spectroscopy (SCRS) via its integrations with other advanced analytical techniques and modern data analytics, enable unprecedented exploration of complex biological and environmental samples with significantly improved specificity, sensitivity, and resolution. Because of the merits of being high-resolution, label-free, non-invasive, molecular-specific, culture-independent, and suitable for in situ, in vitro or in vivo analysis, the SCRS-derived techniques offer abilities superior to conventional bulk measurements for environmental and biological studies. Here, we provide a comprehensive and critical review of the most recent advances in the development and application of SCRS-enabled technologies, with focus on those biomolecular and cellular high-resolution applications in environmental and biological fields.

Medication understanding and health literacy among patients with multiple chronic conditions: A study conducted in Bangladesh.

Medication understanding is critical for patients who suffer from multiple chronic conditions in order to reduce medication error and is often associated with poor health outcomes and low adherence. This study aims to identify the gap of medication knowledge among multiple chronic condition patients in Bangladesh, in order to aid physicians and other healthcare providers in improving health literacy. Individual interviews of a convenience sample of multiple chronic condition patients in Bangladesh were held where they were asked a number of questions for assessing medication related literacy.

Enhancement of Mechanical Properties and Porosity of Concrete Using Steel Slag Coarse Aggregate.

This paper investigates the possibility of utilizing steel slags produced in the steelmaking industry as an alternative to burnt clay brick aggregate (BA) in concrete. Within this context, physical, mechanical (i.e.

Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder.

Background: The alterations of biological markers are thought to be effective tools to understand the pathophysiology and management of major depressive disorder (MDD). A lot of researches has implied many markers for depression, but any of them fully discovered the association between the markers and depression. The present study investigated the serum levels of amino acids and non-enzymatic antioxidants in major depression, and also explained their association with depression.