Bioaccumulation mechanisms of perfluoroalkyl substances (PFASs) in aquatic environments: Theoretical and experimental insights.

Per- and polyfluoroalkyl substances (PFASs) are persistent, bioaccumulative contaminants found in water resources at levels hazardous to human health. However, the PFAS bioaccumulation mechanism remains poorly understood. In this study, we incorporated density functional theory (DFT), molecular dynamics (MD), and experiments to analyze the partitioning pathways and to establish the structure-bioaccumulation relationship.

2D/2D Hydrogen-Bonded Organic Frameworks/Covalent Organic Frameworks S-Scheme Heterojunctions for Photocatalytic Hydrogen Evolution.

Hydrogen-bonded organic frameworks (HOFs) demonstrate significant potential for application in photocatalysis. However, the low efficiency of electron-hole separation and limited stability inhibit their practical utilization in photocatalytic hydrogen evolution from water splitting. Herein, the novel dual-pyrene-base supramolecular HOF/COF 2D/2D S-scheme heterojunction between HOF-HTBAPy (Py-HOF, HTBAPy represents the 1,3,6,8-tetrakis (p-benzoic acid) pyrene) and Py-COF was successfully established using a rapid self-assembly solution dispersion method.

Identification of hub genes in the crosstalk between type 2 diabetic nephropathy and obesity according to bioinformatics analysis.

Diabetic nephropathy (DN) and obesity bring a huge burden to society. Obesity plays a crucial role in the progression of type 2 DN, but the pathophysiology remains unclear. Thus, we aimed the explore the association between type 2 DN and obesity using bioinformatics method.

Higher Serum Galectin‑3 Levels Were Associated with More Severe Motor Performance in Parkinson's Disease.

Background: Parkinson's disease (PD) is a movement disorder that lacks proven biomarkers. Case-control genome-wide association studies revealed the potential effect of galectin‑3 (GAL3) on motor progression in PD patients. Based on this finding, our study aimed to explore the correlation between serum GAL3 levels and motor performance in PD patients.

Interpretation knowledge extraction for genetic testing via question-answer model.

Background: Sequencing-based genetic testing is widely used in biomedical research, including pathogenic microorganism detection with metagenomic next-generation sequencing (mNGS). The application of sequencing results to clinical diagnosis and treatment relies on various interpretation knowledge bases. Currently, the existing knowledge bases are primarily built through manual knowledge extraction.

Optimization of process parameters for polishing aero-engine blade with abrasive cloth wheel considering spindle vibration and polished roughness.

The vibration of machine tool spindle is very important for machining. Firstly, in order to explore the relationship between spindle vibration and process parameters, the spindle vibration acceleration when polishing aero-engine blade was measured, and the quadratic polynomial models between the spindle vibration acceleration in X, Y and Z direction and the process parameters were established. Secondly, a quadratic polynomial model for the influence of process parameters on polished surface roughness was also determined.

CuO/Cu(OH)@g-CN derived from CuBTC/g-CN for two channel photocatalytic hydrogen peroxide production.

Photocatalytic production of HO is indeed a safe, sustainable and cost-effective technology, offering an environmentally friendly solution to the energy crisis through solar photocatalysis. However, it still faces challenges such as reliance on organic electron donors and pure O, as well as inefficiencies in hole utilization. To overcome these limitations, a dual-channel photocatalytic system has been developed.

Carbonate weakens the interactions between potassium and calcareous soil.

The ion interfacial transport driven by ion-surface interactions in calcareous soil has a profound impact on the nutrient storage and environmental buffer capacity of the main agricultural soils in dry and semi-arid areas. The roles that carbonate plays in preserving the soil's inorganic carbon pool and soil structure stability have been widely investigated, but its significance in the aforementioned microscopic processes, especially the influence of carbonate on the interfacial reaction kinetics of nutrient elements, is yet to be determined. In this study, potassium (K) was used as an indicator ion to investigate its affinity in carbonate-removed (CREM) and carbonate-reserved (CRES) calcareous soil using the general theory of ion diffusion in an external electric field.

Capivasertib augments chemotherapy via Akt inhibition in preclinical small cell lung cancer models.

Background: Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer for which platinum-based chemotherapy is the standard of care. Despite an initial response to this therapy, patients eventually develop resistance to the chemotherapy.

Objectives: To investigate the potential of capivasertib, an approved drug for advanced breast cancer, to enhance the efficacy of cisplatin in preclinical SCLC models and explore the underlying mechanisms.

A Novel Cortex Phellodendri Chinensis-Based Carbon Dots Platform for Remarkable Analgesia for Clinical Pain Management.

In this study, we explored the eco-friendly synthesis of photoluminescent CCDs employing a direct one-step pyrolysis process, utilizing natural Cortex Phellodendri Chinensis as the precursor material and studied their analgesic effect in mice. The synthesized carbon dots underwent comprehensive characterization through a range of spectroscopic and microscopic techniques. These included UV-Vis, FTIR, fluorescence spectroscopy and HR-TEM, DLS instruments.

Effect of iron-based nanomaterials on organic carbon dynamics and greenhouse gas emissions during composting process.

Iron-based nanomaterials as effective additives can enhance the quality and safety of compost. However, their influence on organic carbon fractions changes and greenhouse gas emissions during composting remains unclear. This study demonstrated that iron-based nanomaterials facilitate the conversion of light organic carbon fraction into heavy organic carbon fraction, with the iron-based nanomaterials group showing a significantly higher heavy organic carbon fraction content (41.

TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy.

Background: Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression and autoimmune disease activity. As B cell differentiation and autoantibody production exacerbate autoimmune disease, the signaling pathways involved in these processes were explored.

Temporal dynamics of immune cell patterns in bladder cancer patients receiving Bacillus Calmette-Guérin therapy.

Background: Bacillus Calmette-Guérin (BCG) is capable of enhancing the infiltration of immune cells into the tumour. However the temporal dynamics of immune cell patterns in patients receiving BCG instillation remains unclear.

Methods: Ninety-six patients who underwent intravesical BCG therapy, comprising 46 responders and 50 non-responders, were retrospectively enroled to explore the evolving immune landscape.

Characterization and phylogenetic analysis of the chloroplast genome of aff. .

The genus (Ebenaceae) has significant economic value. During field surveys, we discovered a specimen showing morphological overlap with both . and var.

Afrotropical Rohwer, 1914 (Hymenoptera, Braconidae) with description of four new species.

The braconid parasitoid wasp genus Rohwer, 1914 is revised for the Afrotropical region, with four new species described; Liu & Polaszek, , Liu & Polaszek, , Liu & Polaszek, , and Liu & Polaszek, are described based on specimens from the Natural History Museum, United Kingdom, and the Royal Museum for Central Africa, Belgium. An illustrated key to species in the Afrotropical region is provided.

[A meta-analysis of the prevalence of work-related musculoskeletal disorders among rehabilitation therapists].

To investigate the prevalence of work-related musculoskeletal disorders (WMSDs) in rehabilitation therapists. In September 2023, the computer searched Chinese and English databases such as CNKI database, Wanfang Data Knowledge Service Platform, VIP Chinese Science and Technology Journal Database, Chinese Biomedical Literature Database, PubMed, Cochrane Library, Web of Science, Embase database, etc. The retrieval time was from the establishment of the database to September 2023.

Transcriptomic and Proteomic Analyses of the Immune Mechanism in Pathogenetic and Resistant Chinese Soft-Shelled Turtle () Infected with .

Background: As intensive aquaculture practices have progressed, the prevalence of bacterial diseases in the Chinese soft-shell turtle () has escalated, particularly infections caused by , such as ulcerative dermatitis and abscess disease. Despite this, little is known about their immune defenses against this pathogen.

Methods: Our study pioneers an integrated analysis of transcriptomics and proteomics to investigate the immune responses of Chinese soft-shelled turtles to infection.

Mitochondrial Phylogenomics of Scoliidae from China, with Evidence to Challenge the Former Placement of the Group.

Scoliidae, also known as scarab hunters or flower wasps, are important in the biological control of scarabs and for pollination. Mitogenomic and phylogenetic studies are rare for this group. In this study, 10 mitochondrial genomes representing eight genera in two tribes of the family Scoliidae were determined.

The potential mechanism of mitochondrial homeostasis in postoperative neurocognitive disorders: an in-depth review.

Postoperative neurocognitive disorders (PND) are the most common neurological disorders following surgery and anaesthesia before and within 12 months after surgery, with a high prevalence in the geriatric population. PND can severely deteriorate the quality of life of patients, especially among the elderly, mainly manifested as memory loss, attention, decline and language comprehension disorders, mostly in elderly patients, with an incidence as high as 31%. Previous studies have also raised the possibility of accelerated cognitive decline and underlying neuropathological processes associated with diseases that affect cognitive performance (e.