3 results match your criteria: "University of Arkansas for Medical Science and Arkansas Children's Hospital[Affiliation]"
Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes.
Nat Commun
October 2023
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Mutations of several genes cause incomplete penetrance and variable expressivity of phenotypes, which are usually attributed to modifier genes or gene-environment interactions. Here, we show stochastic gene expression underlies the variability of somite segmentation defects in embryos mutant for segmentation clock genes her1 or her7. Phenotypic strength is further augmented by low temperature and hypoxia.
View Article and Find Full Text PDFEffects of continuous positive airway pressure/positive end-expiratory pressure and pressure-support ventilation on work of breathing, using an animal model.
Respir Care
July 2003
Department of Pediatrics, University of Arkansas for Medical Science and Arkansas Children's Hospital, Little Rock AR 72202, USA.
Objective: Evaluate the effects of continuous positive airway pressure (CPAP)/positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV) on work of breathing (WOB).
Methods: With 13 anesthetized lambs we measured WOB with an esophageal balloon and flow signals. All the animals were sedated, intubated, and ventilated, using 2 pediatric ventilators (Servo 300 and VIP Bird).