Statement in Support of Diversity, Equity, and Inclusion for AGU GeoHealth Section.

This commentary presents the American Geophysical Union's GeoHealth section statement in support of diversity, equity, and inclusion (DEI). The GeoHealth section is an open community that represents diverse backgrounds in the geophysical, biological, and public health sciences that share a passion for research at the nexus of Earth and health sciences. The GeoHealth section will aim to advance our understanding of the interactions between the environment, human health, and well-being while supporting DEI topics.

Single Cell Transcriptomic Profiling of -Associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process But Not Gene Expression.

Background: Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease where the most frequently associated mutations occur in the myosin-binding protein C () sarcomere-associated gene. HCM is also a common veterinary clinical problem in certain cat breeds such as Maine Coons and Ragdolls, also most associated with mutations in . Mouse models of HCM in which mutations are introduced recapitulate some, but not all, features of human HCM.

Development of phenyllactic acid ionic liquids and evaluation of cytotoxicity to human cervical epithelial cells.

Phenyllactic acid (PLA), is a naturally produced, broad-spectrum antimicrobial compound with activity against bacteria and fungi. PLA can be produced by a variety of lactic acid bacteria, including vaginal species, which are healthy constituents of the vaginal microbiome with a protective role against invading pathogenic bacteria and/or fungi. Additionally, PLA has been shown to exhibit anti-inflammatory and immunomodulatory properties, overall indicating its therapeutic potential as an intravaginally delivered compound for modulation of the vaginal microbiome.

Immunomodulatory zymosan/ι-carrageenan/ agarose hydrogel for targeting M2 to M1 macrophages (antitumoral).

Several studies have been performed on the immunomodulatory effects of yeast β-(1,3) glucan, but there is no proper evaluation of the thermal and immunomodulating properties of zymosan (ZM). Thermogravimetry analysis indicated a 54% weight loss of ZM at 270 °C. Circular dichroism showed absorption peaks in the region of 250 to 400 nm, suggesting a helical coil β-sheet configuration.

iCPET Calculator: A Web-Based Application to Standardize the Calculation of Alpha Distensibility in Patients With Pulmonary Arterial Hypertension.

Background Pulmonary vascular distensibility associates with right ventricular function and clinical outcomes in patients with unexplained dyspnea and pulmonary hypertension. Alpha distensibility coefficient is determined from a nonlinear fit to multipoint pressure-flow plots. Study aims were to (1) create and test a user-friendly tool to standardize analysis of exercise hemodynamics including distensibility, and (2) investigate changes in distensibility following treatment in patients with pulmonary arterial hypertension.

Assessing the bio-stability of microRNA-146a conjugated nanoparticles electroanalysis.

The number of diabetics is increasing worldwide and is associated with significant instances of clinical morbidity. Increased amounts of reactive oxygen species (ROS) and proinflammatory cytokines are associated with the pathogenesis of diabetic wounds and result in a significant delay in healing. Our previous studies have shown the ability of a cerium oxide nanoparticle (CNP) formulation conjugated with the anti-inflammatory microRNA miR146a (CNP-miR146a) to enhance the healing of diabetic wounds.

Chemical Mohometry: Assessing Crustal Thickness of Ancient Orogens Using Geochemical and Isotopic Data.

Convergent plate boundaries are key sites for continental crustal formation and recycling. Quantifying the evolution of crustal thickness and paleoelevation along ancient convergent margins represents a major goal in orogenic system analyses. Chemical and in some cases isotopic compositions of igneous rocks formed in modern supra-subduction arcs and collisional belts are sensitive to Moho depths at the location of magmatism, implying that igneous suites from fossil orogens carry information about crustal thickness from the time they formed.

Does Large-Scale Crustal Flow Shape the Eastern Margin of the Tibetan Plateau? Insights From Episodic Magmatism of Gongga-Zheduo Granitic Massif.

The mechanisms driving crustal deformation and uplift of orogenic plateaus are fundamental to continental tectonics. Large-scale crustal flow has been hypothesized to occur in eastern Tibet, but it remains controversial due to a lack of geologic evidence. Geochemical and isotopic data from Cenozoic igneous rocks in the eastern Tibet-Gongga-Zheduo intrusive massif, provide a way to test this model.

Biogeosciences Perspectives on Integrated, Coordinated, Open, Networked (ICON) Science.

This article is composed of three independent commentaries about the state of ntegrated, oordinated, pen, etworked (ICON) principles in the American Geophysical Union Biogeosciences section, and discussion on the opportunities and challenges of adopting them. Each commentary focuses on a different topic: (a) Global collaboration, technology transfer, and application (Section 2), (b) Community engagement, community science, education, and stakeholder involvement (Section 3), and (c) Field, experimental, remote sensing, and real-time data research and application (Section 4). We discuss needs and strategies for implementing ICON and outline short- and long-term goals.

The Tides of Enceladus' Porous Core.

The inferred density of Enceladus' core, together with evidence of hydrothermal activity within the moon, suggests that the core is porous. Tidal dissipation in an unconsolidated core has been proposed as the main source of Enceladus' geological activity. However, the tidal response of its core has generally been modeled assuming it behaves viscoelastically rather than poroviscoelastically.

In Situ Measurements of Thermal Ion Temperature in the Martian Ionosphere.

In situ measurements of ionospheric and thermospheric temperatures are experimentally challenging because orbiting spacecraft typically travel supersonically with respect to the cold gas and plasma. We present temperatures in Mars' ionosphere derived from data measured by the SupraThermal And Thermal Ion Composition instrument onboard the Mars Atmosphere and Volatile EvolutioN spacecraft. We focus on data obtained during nine special orbit maneuvers known as Deep Dips, during which MAVEN lowered its periapsis altitude from the nominal 150 to 120 km for 1 week in order to sample the ionospheric main peak and approach the homopause.

Biogeographical Classification of the Global Ocean From BGC-Argo Floats.

Biogeographical classifications of the global ocean generalize spatiotemporal trends in species or biomass distributions across discrete ocean biomes or provinces. These classifications are generally based on a combination of remote-sensed proxies of phytoplankton biomass and global climatologies of biogeochemical or physical parameters. However, these approaches are limited in their capacity to account for subsurface variability in these parameters.

Orbital Forcing of Martian Climate Revealed in a South Polar Outlier Ice Deposit.

Deciphering paleoclimate on Mars has been a driving goal of Martian science for decades. Most research has addressed this issue by studying Mars' large polar layered deposits (PLDs) as a paleoclimate proxy, but the certainty to which we know the link between climate and orbit is debated. Here, we instead consider the record of other, smaller ice deposits located within craters separated from the PLDs using images from NASA's High Resolution Imaging Science Experiment camera and signal processing techniques.

Structural and Thermal Evolution of an Infant Subduction Shear Zone: Insights From Sub-Ophiolite Metamorphic Rocks Recovered From Oman Drilling Project Site BT-1B.

Subduction interface thermal structure changes drastically within the first few million years of underthrusting (i.e., ).

Active Mars: A Dynamic World.

Mars exhibits diverse surface changes at all latitudes and all seasons. Active processes include impact cratering, aeolian sand and dust transport, a variety of slope processes, changes in polar ices, and diverse effects of seasonal CO frost. The extent of surface change has been surprising and indicates that the present climate is capable of reshaping the surface.

No Consistent Link Between Dust Storms and Valley Fever (Coccidioidomycosis).

Dust storms, such as those associated with haboobs and strong regional winds, are frequently assumed to cause increases in cases of Valley fever (coccidioidomycosis). The disease is caused by inhaling arthroconidia of fungi that, after being disturbed from semi-desert subsoil, have become airborne. Fungal arthroconidia can be transported in low-wind conditions as well as in individual dust events, but there is no reliable evidence that all or most dust storms consistently lead to subsequent increases in coccidioidomycosis cases.

Accurate Simulation of Both Sensitivity and Variability for Amazonian Photosynthesis: Is It Too Much to Ask?

Estimates of Amazon rainforest gross primary productivity (GPP) differ by a factor of 2 across a suite of three statistical and 18 process models. This wide spread contributes uncertainty to predictions of future climate. We compare the mean and variance of GPP from these models to that of GPP at six eddy covariance (EC) towers.

The Impact of COVID-19 on Freshwater Fisheries Fieldwork and Data Collection.

COVID-19 has affected almost every aspect of society including freshwater fisheries fieldwork. Our study quantified the effects of the pandemic on fisheries fieldwork in the United States. We administered a survey to fisheries chiefs in all 50 states to assess the pandemic's impact on fisheries fieldwork.

Description and Demonstration of the Coupled Community Earth System Model v2 - Community Ice Sheet Model v2 (CESM2-CISM2).

Earth system/ice-sheet coupling is an area of recent, major Earth System Model (ESM) development. This work occurs at the intersection of glaciology and climate science and is motivated by a need for robust projections of sea-level rise. The Community Ice Sheet Model version 2 (CISM2) is the newest component model of the Community Earth System Model version 2 (CESM2).

A Single-Year Cosmic Ray Event at 5410 BCE Registered in C of Tree Rings.

The annual C data in tree rings is an outstanding proxy for uncovering extreme solar energetic particle (SEP) events in the past. Signatures of extreme SEP events have been reported in 774/775 CE, 992/993 CE, and ∼660 BCE. Here, we report another rapid increase of C concentration in tree rings from California, Switzerland, and Finland around 5410 BCE.

Opium poisoning following self-medication of radiation-induced dermatitis with topical use of opium latex traditional extract; a teaching case.

Despite Radiation-induced dermatitis is a self-limiting complication, it can be complicated if inappropriate self-medications have been used such as opium latex traditional extract.

Atrial fibrillation in the elderly population: Challenges and management considerations.

Importance: Atrial fibrillation is the most clinically significant arrhythmia in humans when viewed both from a global and also a national perspective. In the United States, approximately 2.7-6.

The Viscous and Ohmic Damping of the Earth's Free Core Nutation.

The cause for the damping of the Earth's free core nutation (FCN) and the free inner core nutation eigenmodes has been a matter of debate since the earliest reliable estimations from nutation observations were made available. Numerical studies are difficult given the extreme values of some of the parameters associated with the Earth's fluid outer core, where important energy dissipation mechanisms can take place. We present a fully 3D numerical model for the FCN capable of describing accurately viscous and Ohmic dissipation processes taking place in the bulk of the fluid core as well as in the boundary layers.