The role of optometry in healthcare for visually impaired older adult populations: a Swiss case study.

Background: Visual impairment (VI) is common among older adults aged 70 years and older, and its prevalence increases with advancing age. The optometry profession may play an important role in a patient-centred health system that incorporates medical and psychosocial aspects by working closely with low vision counselling services (LVCS). This paper investigates the current level of cooperation between optometry and LVCS by analysing the referral practice of optometrists to LVCS for the older population with VI, based on the PROVIAGE study.

Ocular thermography and clinical measurements in symptomatic and asymptomatic soft contact lens wearers.

Significance: Symptoms of dryness and discomfort are the main reasons for contact lens dropout. Clinical tests for this purpose are invasive or subjective. Ocular thermography may help to assess the ocular discomfort and dryness in a noninvasive and objective manner.

Visual rehabilitation with mini scleral contact lenses in scarred corneas.

Purpose: To present a case series of patients with corneal scars who were successfully fitted with mini scleral contact lenses (mSCL).

Methods: Case series study.

Results: Six eyes of six patients with corneal scars were fitted with mSCLs.

Patient-specific implants made of 3D printed bioresorbable polymers at the point-of-care: material, technology, and scope of surgical application.

Background: Bioresorbable patient-specific additive-manufactured bone grafts, meshes, and plates are emerging as a promising alternative that can overcome the challenges associated with conventional off-the-shelf implants. The fabrication of patient-specific implants (PSIs) directly at the point-of-care (POC), such as hospitals, clinics, and surgical centers, allows for more flexible, faster, and more efficient processes, reducing the need for outsourcing to external manufacturers. We want to emphasize the potential advantages of producing bioresorbable polymer implants for cranio-maxillofacial surgery at the POC by highlighting its surgical applications, benefits, and limitations.

Bryophyllum pinnatum Inhibits Oxytocin and Vasopressin Signaling in Myometrial Cells.

The medicinal plant was previously shown to block oxytocin (OT)-induced signals in myometrial cells, consistent with its tocolytic effect observed in patients. OT activates not only OT receptors but also V receptors, two receptors with high receptor homology that are both expressed in the myometrium and play a crucial role in myometrial contraction signaling. We aimed to study the molecular pharmacology of herbal preparations using specific receptor ligands, the human myometrial cell line hTERT-C3, and cell lines expressing recombinant human OT and V receptors.

Manganese reductive dissolution coupled to Sb mobilization in contaminated shooting range soil.

A "redox-stat" R bioreactor was employed to simulate moderately reducing conditions (+ 420 mV) in Sb-contaminated shooting range soils for approximately 3 months, thermodynamically favoring Mn(IV) reduction. The impact of moderately reducing conditions on elemental mobilization (Mn, Sb, Fe) and speciation [Sb(III) versus Sb(V); Fe/Fe] was compared to a control bioreactor R without a fixed redox potential. In both bioreactors, reducing conditions were accompanied by an increase in effluent Sb(V) and Mn(II) concentrations, suggesting that Sb(V) was released through microbial reduction of Mn oxyhydroxide minerals.

Advancing forensic research: An examination of compositional data analysis with an application on petrol fraud detection.

In recent years, numerous studies have examined the chemical compounds of petrol and petrol data for forensic research. Standard quantitative methods often assume that the variables or compounds do not have compositional constraints or are not part of a constrained whole, operating within an Euclidean vector space. However, chemical compounds are typically part of a whole, and the appropriate vector space for their analysis is the simplex.

A Perfused In Vitro Human iPSC-Derived Blood-Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies.

Delivering biologics to elicit a therapeutic response in the central nervous system (CNS) remains challenging due to the presence of the blood-brain barrier (BBB). Receptor-mediated transcytosis is a strategy to improve brain exposure after systemic drug administration. The availability of a clinically relevant in vitro BBB model is crucial to investigate transcytosis pathways and to predict the penetration of biologics into the CNS.

Neuroanatomical Disposition, Natural Development, and Training-Induced Plasticity of the Human Auditory System from Childhood to Adulthood: A 12-Year Study in Musicians and Nonmusicians.

Auditory perception is fundamental to human development and communication. However, no long-term studies have been performed on the plasticity of the auditory system as a function of musical training from childhood to adulthood. The long-term interplay between developmental and training-induced neuroplasticity of auditory processing is still unknown.

Corneal sensitivity in silicone hydrogel and rigid gas permeable contact lens wear.

Purpose: The aim of this prospective cross-sectional cohort study was to test the effect of silicone hydrogel (SH) and rigid gas permeable (RGP) contact lens (CL) wear on corneal sensitivity, applying the new Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) and the Cochet-Bonnet (CB) aesthesiometer, based on subject feedback (psychophysical method).

Methods: Participants were recruited for three equally large groups: Group A (SH CL), Group B (RGP CL) and Group C (non-CL wearers). Inclusion criteria were healthy eyes and OSDI ≤ 13.

Occupational Health Risk Assessment for Wastewater Treatment and Reuse in Kanpur, India.

The treatment and reuse of wastewater for irrigation can lead to occupational health risks for sewage treatment plant (STP) workers and farmers. Sanitation Safety Planning (SSP) is an approach which can be used to measure and mitigate these risks. This paper explores what impact a novel secondary treatment process, consisting of an integrated permeate channel (IPC) membrane combined with a constructed wetland plus, has on the occupational health risks compared with the existing activated sludge wastewater treatment process and reuse system in Kanpur, Uttar Pradesh.

Reduction of the vertical vestibular-ocular reflex in military aircraft pilots exposed to tactical, high-performance flight.

Background: Exposure to high-performance flight stresses the vestibular system and may lead to adaptive changes in the vestibular responses of pilots. We investigated the vestibular-ocular reflex of pilots with different histories of flight exposure both with respect to hours of flight and flight conditions (tactical, high-performance vs. non-high-performance) to evaluate if and how adaptative changes are observable.

Parameter optimization in a finite element mandibular fracture fixation model using the design of experiments approach.

Only a few mandibular bone finite element (FE) models have been validated in literature, making it difficult to assess the credibility of the models. In a comparative study between FE models and biomechanical experiments using a synthetic polyamide 12 (PA12) mandible model, we investigate how material properties and boundary conditions affect the FE model's accuracy using the design of experiments approach. Multiple FE parameters, such as contact definitions and the materials' elastic and plastic deformation characteristics, were systematically analyzed for an intact mandibular model and transferred to the fracture fixation model.

Clinical application of the Swiss Liquid Jet Aesthesiometer for corneal sensitivity measurement.

Clinical Relevance: Corneal sensitivity represents an important indicator for corneal health, its innervation and hence also for ocular disease. It is therefore of great interest from a clinical and research perspective to quantify ocular surface sensation.

Background: The aim of this prospective cross-sectional cohort study was to clinically test the within-day and day-to-day repeatability of the new Swiss Liquid Jet Aesthesiometer, employing small droplets of isotonic saline solution for repeatability, and correlate with the Cochet-Bonnet aesthesiometer in a cohort of participants of two different age groups, based on participant feedback (psychophysical method).

Why and how unpredictability is implemented in aviation security - A first qualitative study.

In the past, aviation security regulations have mostly been reactive, responding to terrorist attacks by adding more stringent measures. In combination with the standardization of security control processes, this has resulted in a more predictable system that makes it easier to plan and execute acts of unlawful interference. The implementation of unpredictability, that is, variation of security controls, as a proactive approach could be beneficial for addressing risks coming from outside (terrorist attacks) and inside the system (insider threats).

Age-Related Changes in Corneal Sensitivity.

Purpose: The aim of this prospective cross-sectional cohort study was to clinically test whether corneal sensation decreases with age, based on subject feedback (psychophysical method), and whether it correlates with general pain perception.

Methods: Subjects were recruited from 2 equally large age groups: group A (18-30 years) and group B (50-70 years; n = 45 per group). The inclusion criteria were healthy eyes, Ocular Surface Disease Index ≤13, and no contact lens wear.

A closer look at the domain-specific associations of openness with language achievement: Evidence on the role of intrinsic value from two large-scale longitudinal studies.

Background: Many empirical investigations focus on how personality traits and academic motivation are related to academic achievement. Regarding the personality traits described in the five-factor model, prior research has shown associations between openness to experience and language achievement in particular. Following the principle of trait activation, associations with intrinsic value can explain these domain-specific relationships of openness with achievement.

Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines.

The five-year survival rate for women with ovarian cancer is very poor despite radical cytoreductive surgery and chemotherapy. Although most patients initially respond to platinum-based chemotherapy, the majority experience recurrence and ultimately develop chemoresistance, resulting in fatal outcomes. The current administration of cytotoxic compounds is hampered by dose-limiting severe adverse effects.

Musicianship-Related Structural and Functional Cortical Features Are Preserved in Elderly Musicians.

Background: Professional musicians are a model population for exploring basic auditory function, sensorimotor and multisensory integration, and training-induced neuroplasticity. The brain of musicians exhibits distinct structural and functional cortical features; however, little is known about how these features evolve during aging. This multiparametric study aimed to examine the functional and structural neural correlates of lifelong musical practice in elderly professional musicians.

The Mechanical Characterization of Welded Hybrid Joints Based on a Fast-Curing Epoxy Composite with an Integrated Phenoxy Coupling Layer.

The joining of composites mostly relies on traditional joining technologies, such as film or paste adhesives, or mechanical fasteners. This study focuses on the appealing approach of using standard thermoplastic welding processes to join thermosets. To achieve this, a thermoplastic coupling layer is created by curing with a thermoset composite part.

Working principle and relevant physical properties of the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) evaluation.

Purpose: To describe and evaluate relevant physical properties of the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) for ocular surface sensitivity measurement.

Methods: Characteristics of Liquid Jet (LJ) droplets (consisting of isotonic saline solution) were analysed: vertical and horizontal displacement and speed of LJ droplets were recorded with the aid of the High Speed Photron FASTCAM NOVA S6 camera (stimulus duration: 40 ms). Stimulus mass was assessed for 20 sets of 10 LJs with aid of a microbalance (pressure range of 100-1500 mbar).

A qualitative study on safety perception among healthcare workers of a tertiary academic care center during the SARS-CoV-2 pandemic.

Background: Protecting healthcare workers (HCWs) from exposure to SARS-CoV-2 during patient care is central to managing the current pandemic. Higher levels of trust in personal protective equipment (PPE) and infection prevention and control (IPC) strategies have been previously related to lower levels of emotional exhaustion, yet little is known on how to achieve such a perception of safety. We thus sought to identify institutional actions, strategies and policies related to HCWs' safety perception during the early phase of the pandemic at a tertiary care center in Switzerland by interviewing HCWs from different clinics, professions, and positions.

Social media use and well-being among older adults.

While older adults (aged 65 years and older) are increasingly using social media, their usage rates still lag those of younger age groups. Social media use has been observed to have some positive effects on older adults' well-being; however, divergent findings exist depending upon the sample, measures, and methodological approach. This review highlights what is currently known about social media use and well-being among older adults, identifies strengths and weaknesses of current research on this topic, and argues that methodological and content-related research gaps must be closed before researchers can confirm a positive overall effect of social media use in everyday situations for older adults.