84 results match your criteria: "University of Antwerp-U.I.A.[Affiliation]"
Am J Med Genet
August 1993
Department of Medical Genetics, University of Antwerp-U.I.A., Belgium.
We report on a fetus with multiple pterygia in the popliteal, antecubital, intercrural, axillary, and nuchal region, arthrogryposis, camptodactyly, anal atresia, hypospadias, ambiguous genitalia, and neonatal death. Arthrogryposis was much more pronounced at the left than at the right side. Moreover, there was gross body asymmetry with hypoplasia of the left arm, leg, pelvis, and kidney.
View Article and Find Full Text PDFJ Pathol
December 1992
Department of Pathology, University Hospital Antwerp, University of Antwerp (U.I.A.), Edegem, Belgium.
The presence of p53 protein in non-neoplastic pleural mesothelium (40 cases) and in human malignant mesothelioma (36 cases) was assessed immunohistochemically using the antibodies DO7, CM-1, and PAb240. In a quarter of the malignant mesotheliomas, there was nuclear immunoreactivity for p53 protein with both the DO7 and CM-1 antibodies. There were no statistically significant differences between the various mesothelioma subtypes (P > 0.
View Article and Find Full Text PDFHum Genet
June 1992
Department of Medical Genetics, University of Antwerp-U.I.A., Wilrijk, Belgium.
We describe two female siblings with similar clinical features consisting of hydrocephalus, scaphocephaly, hypotonia, mongoloid eye slant, blepharophimosis, micrognathia, supernumerary mouth frenula and mental retardation. Routine cytogenetic studies in the elder patient did not reveal any abnormality, and initially it was assumed that the syndrome had an autosomal recessive inheritance. However, a slightly larger chromosome 13 was seen in routine G-banded metaphases of the mother and the youngest of the two siblings.
View Article and Find Full Text PDFBiochim Biophys Acta
March 1992
Department of Pharmaceutical Sciences, University of Antwerp U.I.A., Belgium.
Peptides were extracted from the lysate of isolated bovine chromaffin granules. Following reversed-phase HPLC purification, the fractions were analyzed by FAB/MS. The presence of methionine-enkephalin and leucine-enkephalin was indicated by their chromatographic retention time and by the m/z value of their protonated molecules.
View Article and Find Full Text PDFCytogenet Cell Genet
September 1992
Department of Medical Genetics, University of Antwerp-U.I.A., Belgium.
X-linked liver glycogenosis (XLG) is a glycogen storage disorder resulting from deficient activity of phosphorylase kinase (PHK). PHK consists of four different subunits: alpha, beta, gamma, and delta. Several genes encoding PHK subunits have been cloned and localized, but only the muscle alpha-subunit (PHKA) gene has been assigned to the X chromosome, in the region Xq12----q13.
View Article and Find Full Text PDFAntimicrob Agents Chemother
November 1991
Department of Oto-Rhino-Laryngology, University of Antwerp (U.I.A.), Antwerp-Wilrijk, Belgium.
To investigate the possible effect of the dosing scheme of aminoglycosides on their concentration in the cochlear tissue, we gave two groups of 12 guinea pigs subcutaneous doses of 45 mg of isepamicin (ca. 30 mg of active product) per kg of body weight daily for eight consecutive days. The first group received the drug by continuous infusion, while the second group received it by single daily injection.
View Article and Find Full Text PDFAm J Med Genet
November 1991
Department of Medical Genetics, University of Antwerp-U.I.A., Wilrijk, Belgium.
We report on a child with Fryns syndrome including lung hypoplasia, characteristic facial appearance, cleft palate, cardiac anomaly, distal limb abnormalities, absent nipples, bicornuate uterus and early death. In contrast to most patients with Fryns syndrome, diaphragmatic hernia was absent in our patient. However, the diaphragm was reduced to a fibrous web with reduced muscular component.
View Article and Find Full Text PDFClin Genet
February 1991
Department of Medical Genetics, University of Antwerp-U.I.A., Belgium.
Cloning and sequencing of the CF gene has identified a three-base-pair deletion (delta F508) responsible for CF in the majority of CF patients (Kerem et al. 1989). We have used the polymerase chain reaction with oligonucleotide primers bridging the delta F508 deletion to analyze the presence or absence of this mutation in the Belgian CF population.
View Article and Find Full Text PDFJ Chromatogr
January 1991
Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Wilrijk-Antwerp, Belgium.
The four major C-glycosidic flavonoids isolated from Passiflora incarnata were identified as schaftoside, isoschaftoside, isovetexin-2''-O-glucopyranoside and isoorientin-2''-O-glucopyranoside on the basis of mass spectral and 13C NMR data. The daughter ion spectra of [M + H]+ ions of schaftoside and isoschaftoside showed differences for the [M + H - 104]+ ions, which could be rationalized by hydrogen bonding effects. In the negative-ion mode, pronounced differences were found for the [M - H - 90]- and [M - H - 120]- ions, formed by prevalent fragmentation in the C-6-linked sugar moiety.
View Article and Find Full Text PDFAm J Med Genet
January 1991
Department of Medical Genetics, University of Antwerp/U.I.A., Belgium.
Fucosidosis is a rare, autosomal recessive, lysosomal storage disorder caused by a severe deficiency of alpha-L-fucosidase in all tissues. We have conducted a review of fucosidosis, compiling data from published reports and an international questionnaire survey. Seventy-seven patients affected with fucosidosis of which 19 had not been reported before have been identified.
View Article and Find Full Text PDFCytogenet Cell Genet
November 1991
Department of Medical Genetics, University of Antwerp-U.I.A., Belgium.
FUCA1P is a pseudogene of the structural fucosidase gene FUCA1. The former has been mapped to human chromosome 2, whereas the latter has been localized to chromosome 1p34----p36. We have further localized FUCA1P to chromosomal band 2q31----q32 by fluorescent in situ hybridization and digital imaging microscopy.
View Article and Find Full Text PDFMatrix
March 1990
Department of Medicine, University of Antwerp (U.I.A.), Antwerp-Wilrijk, Belgium.
Repeated intraperitoneal injections of lead acetate in rats caused a calcification of the skin of the abdomen near the site of the injections. In the lead-induced calcifications, electron dense collagen bundles could be observed. On the surface of the collagen fibrils, needle-like crystals were visible.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
February 1990
Department of Chemistry, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610, Wihijk, Belgium.
The quantitative analytical characteristics of a camera-based detection system for secondary ion microscopy are studied in detail. Through multiple exposures, ion images with large dynamic ranges are obtained. The quantification of these images by the sensitivity factor method and the matrix ion species ratio method is described and evaluated by the analysis of steel and aluminum standard reference materials.
View Article and Find Full Text PDFOecologia
September 1989
Department of Biology, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610, Wilrijk, Belgium.
We studied, in the field and laboratory, aspects of the thermal biology in two populations of the lizard Podarcis tiliguerta along a 1450 m altitudinal gradient. Body temperatures (T) at high altitudes average lower, are more variable, but are more elevated above environmental temperatures than at sea level. Lizards partially reduced the impact of altitudinal changes in thermal loads through presumable subtle behavioural adjustments.
View Article and Find Full Text PDFSci Total Environ
August 1989
Department of Chemistry, University of Antwerp (U.I.A.), Wilrijk, Belgium.
Various potable water and soil samples have been analyzed for tri- and dialkyllead compounds using a sensitive speciation procedure based on diethyldithiocarbamate extraction, Grignard derivatization and gas chromatography-atomic absorption spectrometry. The species are generally present as ultra-trace contaminants, and their abundance is critically discussed. In addition, a degradation study of ionic alkyllead in ambient matrices is presented.
View Article and Find Full Text PDFPlanta Med
April 1988
Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610 Antwerp, Belgium.
Acta Otolaryngol
August 1988
Department of ORL/ENT, University of Antwerp (U.I.A.), Antwerp-Wilrijk, Belgium.
A histological study was done on the thin, nearly transparent replacement membrane of tympanic membrane perforations. Human tympanic membranes that were rejected for transplantation, were studied by light and electron microscopy. The abrupt reduction in thickness at the margin of the covered perforation, is entirely due to the reduction of the lamina propria.
View Article and Find Full Text PDFActa Cardiol Suppl
July 1988
University of Antwerp (U.I.A.), Division of Pharmacology, Wilrijk, Belgium.
Intensive Care Med
July 1988
Department of Intensive Care, University of Antwerp U.I.A., University Hospital, Edegem, Belgium.
Propylene glycol, an alcohol frequently used as a solvent in medical preparations, is considered non-toxic. We found that this solvent, used in a commercially available IV nitroglycerin solution, may cause hyperosmolality, hemolysis and lactic acidosis. The influence of kidney function as the main determinant in causing accumulation of this solvent and consequently hyperosmolality is emphasized.
View Article and Find Full Text PDFPlanta Med
December 1984
Faculty of Medicine, University of Antwerp (U.I.A.), Universiteits-plein 1, B-2610 Antwerp, Belgium.
An investigation of the constituents responsible for the pronounced antiviral activity observed for extracts of EUPHORBIA GRANTII Oliv. stems has afforded four related 3-methoxyflavones exhibiting remarkable activities against picornaviruses and vesicular stomatitis virus. All compounds were found to be derivatives of 3-methylquercetin.
View Article and Find Full Text PDFTalanta
March 1984
Department of Chemistry, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610 Wilrijk, Belgium.
The breakdown voltage has been found to be dependent on the gap width between the electrodes and on the melting point of the sample elements in spark-source mass-spectrometry (SSMS). The number of discharges per pulse train and the time required to reach the first discharge depend only on the chosen breakdown voltage. The spark gap is proportional to the "radius" of the volume sampled (for a given element) and this radius is linearly related to the reciprocal of the melting point of the elements (23 different elements, metals or semiconductors), when fixed spark-parameters are used.
View Article and Find Full Text PDFTalanta
December 1982
Department of Chemistry, University of Antwerp (U.I.A.), B-2610 Wilrijk, Belgium.
Mounting concern over the presence and the role of organic lead compounds in the environment and living systems has resulted in the development of selective and sensitive measuring techniques. In the last decade considerable efforts have been devoted to the collection of data on the levels of the pollutant in environmental air. The procedures used and the chemical and instrumental problems associated with them, as well as the most important analytical results, are reviewed.
View Article and Find Full Text PDFTalanta
November 1982
Departments of Chemistry, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610 Wilrijk, Belgium.
Two common procedures for wet destruction of biological materials for subsequent determination of selenium have been investigated. Rat organs and biological fluids were endogenously labelled with (75)Se to monitor losses during the procedures. Addition of nitric and perchloric acids with gradual heating up to 210 degrees seemed to be the best method: at this temperature the labelled selenium was still recovered quantitatively, and the destruction was fast and efficient.
View Article and Find Full Text PDFTalanta
October 1982
Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.) Universiteitsplein 1, B-2610 Wilrijk, Belgium.
A systematic investigation has been made of various methods for decomposition of blood and plasma for determination of selenium, and various sources of error have been identified. The method recommended is graded destruction by heating with nitric acid and perchloric acid, to a final temperature of 210 degrees .
View Article and Find Full Text PDFTalanta
October 1982
Department of Chemistry, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610 Wilrijk, Belgium.
This article reviews the different methods used for the determination of selenium species in all types of environmental waters. Basic difficulties are discussed and the efficiency of the methods is explained in view of the sub-mug/1. concentration levels.
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