2 results match your criteria: "University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands W.J.Buma@uva.nl.[Affiliation]"
Establishing PQ-ERA photoclick reactions with unprecedented efficiency by engineering of the nature of the phenanthraquinone triplet state.
Chem Sci
July 2023
Centre for Systems Chemistry, Stratingh Institute for Chemistry, Faculty for Science and Engineering, University of Groningen Nijenborgh 4 9747 AG Groningen The Netherlands
Article Synopsis
- The PQ-ERA reaction is a promising light-activated reaction that combines 9,10-phenanthrenequinone with electron-rich alkenes, noted for its selectivity, control with light, and compatibility with biological systems.
- Researchers found that substituting thiophene at the 3-position of the PQ structure significantly increases the reactivity of the PQ triplet state, overcoming limitations in traditional PQ compounds.
- This enhancement leads to impressive outcomes, including high reaction efficiency (quantum yield up to 98%), increased reaction rates, and good performance in the presence of oxygen, supported by experimental and theoretical findings.
Vibrational circular dichroism spectroscopy for probing the expression of chirality in mechanically planar chiral rotaxanes.
Chem Sci
July 2020
Van 't Hoff Institute for Molecular Sciences, University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands
Mechanically interlocked molecules can exhibit molecular chirality that arises due to the mechanical bond rather than covalent stereogenic units. Developing applications of such systems is made challenging by the absence of techniques for assigning the absolute configuration of products and methods to probe how the mechanical stereogenic unit influences the spatial arrangements of the functional groups in solution. Here we demonstrate for the first time that Vibrational Circular Dichroism (VCD) can be used to not only discriminate between mechanical stereoisomers but also provide detailed information on their (co)conformations.
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