Mechanical determinants of myocardial blood flow and its distribution.

There are two mechanical determinants of coronary blood flow and its distribution: resistance and pressure gradient. Resistance is determined by blood viscosity and the anatomy and geometry of the coronary vascular bed. The coronary vascular pressure gradient is the difference between aortic root pressure and intramyocardial pressure.

Cyanogen bromide splitting of human immunoglobulin M.

Human Waldenstrdm IgM (kappa) (Dau), its polypeptide chains and its F(c)5 micro and Fab micro fragments were split by cyanogen bromide (CNBr). The fragments formed by CNBr were fractionated by gel filtration, ion exchange chromatography and paper electrophoresis. They were characterized in terms of polyacrylamide disc electrophoresis, peptide maps, amino acid composition, end group determinations and limited primary structure determination.

Effect of antibiotic treatment on the incidence of infectious drug resistance among intestinal lactose-fermenting bacteria isolated from burn patients.

Antibiotic-resistant lactose-fermenting bacteria were recovered from the feces of 20 of 25 burn patients studied. Of the Escherichia coli isolated from patients receiving antibiotic treatment, 81.5% were shown to be infectiously resistant; only 32% of the E.

Immunoglobulin determinations in the diagnosis of fetal infection.

Current indications are that the human fetus is not immunologically incompetent. An elevated IgM level may be a nonspecific indicator of a newborn at high risk for intrauterine infections--which may not be clinically apparent.