2 results match your criteria: "University of Alabama at Birmingham Comprehensive Cancer Center Birmingham[Affiliation]"
Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability.
J Cancer
September 2018
Department of Oncology, Southern Research Institute and Cancer Cell Biology Program, University of Alabama at Birmingham Graduate School, Birmingham, AL, 35205.
Understanding the functional significance of the essential elements in maintaining genomic stability provides insights into the process of tumor initiation and progression, and predicts therapeutic responses. One such element that has recently attracted significant attention is the Speckle-Type Poz Protein (SPOP), an E3 ubiquitin ligase adaptor protein. SPOP is frequently mutated or has altered expression in various cancers, including prostate, renal and endometrial.
View Article and Find Full Text PDFPrognostic and Predictive Factors in Patients with Advanced Penile Cancer Receiving Salvage (2nd or Later Line) Systemic Treatment: A Retrospective, Multi-Center Study.
Front Pharmacol
December 2016
Section of Hematology-Oncology, Department of Medicine, University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, AL, USA.
Article Synopsis
- Metastatic penile squamous cell carcinoma (PSCC) has a poor prognosis, with overall survival (OS) times of only 6-12 months in initial treatment and less than 6 months for salvage therapy.
- This study constructed a prognostic model for PSCC patients undergoing second-line or later systemic treatments and assessed treatment outcomes through a retrospective chart review.
- Results showed a median OS of 20 weeks and identified poor prognostic factors, including visceral metastasis and low hemoglobin levels, which adversely affected both OS and progression-free survival (PFS).