THP-1 like macrophages protein-protein interaction map revealed through dual RNA-seq analysis and a computational approach.

Infection caused by ) is still a leading cause of mortality worldwide with estimated 1.4 million deaths annually. Despite macrophages' ability to kill bacterium, can grow inside these innate immune cells and the exploration of the infection has traditionally been characterized by a one-sided relationship, concentrating solely on the host or examining the pathogen in isolation.

L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in rats.

Objective: Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM).

Methods: Male Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4 weeks.

Uncovering the clinical relevance of unclassified variants in DNA repair genes: a focus on negative Tunisian cancer families.

Recent advances in sequencing technologies have significantly increased our capability to acquire large amounts of genetic data. However, the clinical relevance of the generated data continues to be challenging particularly with the identification of Variants of Uncertain Significance (VUSs) whose pathogenicity remains unclear. In the current report, we aim to evaluate the clinical relevance and the pathogenicity of VUSs in DNA repair genes among Tunisian breast cancer families.

French validation of the barriers to access to care evaluation (BACE-3) scale.

Background: The aim of this study was to develop and evaluate a French version of the Barriers to Access to Care Evaluation (BACE-3) scale that is tailored to the socio-cultural and language setting of the study.

Methods: The translation of the BACE-3 into French and its validation were the two key components of this psychometric investigation. An online survey was created and circulated to French-speaking participants who volunteered to participate in the study.

Mediating effect of psychological distress and mindful eating behaviors between orthorexia nervosa and academic self-efficacy among Lebanese university female students.

Objectives: This study examined the mediating effect of psychological distress and mindful eating behaviors between orthorexia nervosa and academic self-efficacy among Lebanese university female students.

Methods: A total of 769 female participants enrolled in this cross-sectional study (mean age 21.58 ± 3.

Lighting the way: Exploring diurnal physical performance differences in school-aged visually impaired children and adolescents.

Circadian rhythms play a pivotal role in governing various physiological processes, including physical performance. However, in individuals deprived of light perception, such as the blind, these circadian rhythms face disruption. This study aimed to explore the influence of disturbed circadian rhythms on short-term maximal physical performance in children and adolescents with visual impairment.

How effective are external cues and analogies in enhancing sprint and jump performance in academy soccer players?

This study investigated the effect of external (EC) and internal coaching cues (IC), analogies with a directional component (ADC) on sprint (20 m) and vertical jump performance in academy soccer players ( = 20). A repeated-measures analysis, with post-hoc comparisons, was used to identify any differences between these cues and a neutral (control) cue. Significant differences were found for both sprint ( < 0.

Stigma of ultra-high risk for psychosis: an updated systematic review.

Objective: To determine whether the stigma associated with schizophrenia has also been directed towards people at ultra-high risk of psychosis (UHR), the present review aimed to synthetize the literature to update and extend our understanding of this topic.

Methods: A systematic review compliant with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted in the PubMed, EMBASE, Cochrane, and Web of Science databases for articles published until April 30, 2023, using a combination of search terms describing at-risk mental states for psychosis, stigma, and related terms.

Results: Thirty-eight studies were included.

The relationship between climate change anxiety and psychotic experiences is mediated by death anxiety.

Background: As climate change persists, accelerates, and intensifies, and since mitigating factors are absent, mental health impacts are expected to follow the same patterns. Therefore, it appears of utmost importance to deepen and broaden the knowledge and understanding of how and through which mechanisms climate change anxiety (CCA) may interplay with mental health outcomes. Based on the stress-vulnerability model of psychosis, the present study proposed to examine the relationship between CCA and psychotic experiences (PEs), and to test the theoretically-driven hypothesis that death anxiety acts as a mediator in this relationship.

Effect of dynamic balance on human mental rotation task in female badminton vs. volleyball players.

Background: The present study aims to compare the mental rotation performance between two non-contact sports (i.e., badminton and volleyball) in different upright conditions (i.

Amino acids and protein profiles of defatted camel and cow milk fractions: correlation with their antioxidant and antidiabetic activities.

Introduction: This work presents proteins, amino acids profiles and antioxidant and properties of camel and cow milk fractions produced using an integrated coagulation-centrifugation process.

Methods: Antioxidant activity using DPPH radical scavenging assay; and antidiabetic activity antidiabetic activity using α-amylase inhibitory activity were assessed on defatted milk fractions and their extracts using water/ethanol or HCl/ethanol solvents. Protein profiles and amino acids composition were analyzed by high-performance liquid chromatography.

Expressive suppression moderates the relationship between PTSD from COVID-19 and somatization and validation of the Arabic version of Patient Health Questionnaire-15 (PHQ-15).

Background: Lebanese adults have been crippled for years by several crises, including the lately COVID-19 pandemic. These massive civilian traumas have increased the risk of post-traumatic stress disorder (PTSD) in this population. Extensive literature pointed to the association between PTSD and somatization; however, the nature of this relationship remains unknown.

Molecular epidemiology, associated risk factors, and phylogeny of infecting buffaloes and cattle from different agro-climatic regions of Punjab, Pakistan.

Background: Tropical theileriosis is the most prevalent hemoprotozoan disease in Pakistan.

Aims: The study aimed to investigate the epidemiology and evolutionary relationship of in bovines in diverse agro-climatic regions of Punjab, Pakistan.

Methods: 800 blood specimens were collected from asymptomatic cattle (n=480) and buffaloes (n=320) using a multistage sampling method from Sargodha (n=400) and Multan (n=400) districts.

A multinational study on the factors influencing university students' attitudes and usage of ChatGPT.

Artificial intelligence models, like ChatGPT, have the potential to revolutionize higher education when implemented properly. This study aimed to investigate the factors influencing university students' attitudes and usage of ChatGPT in Arab countries. The survey instrument "TAME-ChatGPT" was administered to 2240 participants from Iraq, Kuwait, Egypt, Lebanon, and Jordan.

ChatGPT is not ready yet for use in providing mental health assessment and interventions.

Background: Psychiatry is a specialized field of medicine that focuses on the diagnosis, treatment, and prevention of mental health disorders. With advancements in technology and the rise of artificial intelligence (AI), there has been a growing interest in exploring the potential of AI language models systems, such as Chat Generative Pre-training Transformer (ChatGPT), to assist in the field of psychiatry.

Objective: Our study aimed to evaluates the effectiveness, reliability and safeness of ChatGPT in assisting patients with mental health problems, and to assess its potential as a collaborative tool for mental health professionals through a simulated interaction with three distinct imaginary patients.

Relative Cross-Education Training Effects of Male Youth Exceed Male Adults.

Ben Othman, A, Anvar, SH, Aragão-Santos, JC, Behm, DG, and Chaouachi, A. Relative cross-education training effects of male youth exceed male adults. J Strength Cond Res 38(5): 881-890, 2024-Cross-education has been studied extensively with adults, examining the training effects on contralateral homologous muscles.

Lactate-induced autophagy activation: unraveling the therapeutic impact of high-intensity interval training on insulin resistance in type 2 diabetic rats.

Impaired autophagy is a hallmark of diabetes. The current study proposed to investigate if high intensity interval training (HIIT) induced lactate accumulation could stimulate autophagy in type 2 diabetic male rats. 28 male Wistar rats were randomly assigned into four groups: Healthy Control (CO), Diabetes Control (T2D), Exercise (EX), and Diabetes + Exercise (T2D + EX).

Probiotic consortium modulating the gut microbiota composition and function of sterile Mediterranean fruit flies.

The sterile insect technique (SIT) remains a successful approach in managing pest insects. However, the long-term mass rearing and sterilizing radiation associated with SIT have been observed to induce physiological and ecological fitness decline in target insects. This decline may be attributed to various factors, including commensal microbiota dysbiosis, selection procedures, loss of heterozygosity, and other complex interactions.

Toxoplasma gondii infection in small ruminants from Khyber Pakhtunkhwa, Pakistan: Seroprevalence, spatial distribution and associated risk factors.

The primary aim of this investigation was to assess the occurrence of Toxoplasma gondii infection among sheep and goats in five districts within the southern region of Khyber Pakhtunkhwa province, Pakistan. Additionally, the study aimed to pinpoint potential factors associated with the spread of this infection. Serum samples were gathered from a total of 3505 small ruminants, comprising 1810 sheep and 1695 goats.

Does ICT influence carbon emissions in the context of universal connectivity: a global perspective?

The Connect 2030 initiative, launched by the International Telecommunication Union, is in alignment with the Sustainable Development Goals (SDGs) of the United Nations Agenda 2030. Its main objective is to achieve universal connectivity, a goal that is closely related to environmental issues. This topic currently receives attention from researchers and policymakers.

Is isokinetic shoulder strength a determinant of serve ball velocity in tennis?

The tennis serve is closely related to the quality of the tennis match. However, the isokinetic parameters associated with the tennis serve are still unclear. The aim of this study was to investigate the relationships between ball velocity and isokinetic shoulder strength in tennis serve and to determine isokinetic strength parameters that can predict tennis serve velocity.

The effects of training type and area size variations on the physiological and session rating of perceived exertion responses during male judo matches.

Modified exercise prescription in judo is commonly used to activate the energy systems in different magnitudes. In order to study the physiological and rating of perceived exertion (RPE) responses according to area sizes (i.e.

Moderating effect of alexithymia between problem gambling and psychotic experiences in university students.

Background: Most of the young individuals with problem gambling (PG) or psychotic experiences (PEs) are less prone to seek medical help. Therefore, community-based studies investigating the relationship between these entities in non-clinical young people across a continuum of severity are warranted. To this end, the present study proposes to advance knowledge on the mechanisms that potentially underlie the association between PG and PEs, by examining the role of a potential moderator, i.