83 results match your criteria: "University of "G. d'Annunzio" of Chieti and Pescara[Affiliation]"

Purpose: To quantitatively explore preretinal abnormal tissue (PAT) in macula-on rhegmatogenous retinal detachment (RRD) before and after surgery.

Methods: In this case-series study, PAT was detected by en-face optical coherence tomography images with custom slabs in eyes that underwent pars plana vitrectomy and SF6 for macula-on RRD.Main outcome measures were PAT area at baseline, 3-month and 6-month follow-up, and its relative change.

View Article and Find Full Text PDF

When neuromodulation met control theory.

J Neural Eng

December 2024

Department of Neuroscience, Imaging and Clinical Sciences, Universita degli Studi Gabriele d'Annunzio Chieti e Pescara, Via dei Vestini 33, Chieti Scalo, CH, 66013, ITALY.

The brain is a highly complex physical system made of assemblies of neurons that work together to accomplish elaborate tasks such as motor control, memory and perception. How these parts work together has been studied for decades by neuroscientists using neuroimaging, psychological manipulations, and neurostimulation. Neurostimulation has gained particular interest, given the possibility to perturb the brain and elicit a specific response.

View Article and Find Full Text PDF

Introduction: The Brief Index of Sexual Functioning for Women (BISF-W) is an international 4-factors tool assessing qualitative and quantitative aspects of sexual experiences in women, both in clinical and experimental settings. The present research aims at validating an Italian version of the BISF-W, to develop a BISF version for men (BISF-M) to fill the gap in the existing sexual function evaluation tools in Italy and to analyze gender and age groups differences in the BISF factors.

Methods: The research included 6,355 women, aged from 18 to 65 ( = 34.

View Article and Find Full Text PDF

A Right Ear Advantage (REA) is well-established in perceptual tasks but it has been found also during imagery. It is ascribed to the left temporoparietal activity for language, and it can be absent/reversed in some clinical conditions including auditory hallucinations. We applied 1-Hz repetitive TMS over TP3/TP4 (left/right language areas) identified through neuronavigation in 18 healthy participants, before administering a modified white noise (WN) speech illusion paradigm: a voice was presented at one ear, at the same or lower intensities with respect to binaural WN.

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to create guidelines that help balance sports and work commitments for athletes, incorporating feedback from both employee-athletes and their employers.
  • Using concept mapping, 257 participants ranked statements related to dual careers, leading to six key clusters that highlight different aspects of workplace support.
  • The results indicate a need for flexible models that align business values with support for employee-athletes, providing a strong evidence base for new dual career workplace guidelines.
View Article and Find Full Text PDF

Nanotechnology has gained popularity in recent years due to its wide-ranging applications within the scientific community. The three main methods for synthesizing nanoparticles are physical, chemical, and biological. However, the adverse effects associated with physical and chemical methods have led to a growing interest in biological methods.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how financialization affects the investment and financing maturity mismatch in Chinese A-share listed companies from 2013 to 2020, emphasizing the importance of understanding behavioral motives behind financialization for China's real economy development.! -
  • It finds a complex relationship shaped like an inverted U: as financialization increases, the maturity mismatch grows until a critical point, after which it starts to ease, with investment income financialization worsening the mismatch and fixed income financialization improving it.! -
  • The impact of financializing different asset types varies based on factors like ownership structure and financing constraints, while financial regulation is shown to moderate the relationship between financialization and maturity mismatch, making the effects of financialization more pronounced or less severe depending
View Article and Find Full Text PDF

Introduction: There is a growing interest in characterizing the cognitive-motor processes that underlie superior performance in highly skilled athletes. The aim of this study was to explore neural markers of putting performance in highly skilled golfers by recording mobile EEG (electroencephalogram) during the pre-shot period.

Methods: Twenty-eight right-handed participants (20 males) with a mean age of 24.

View Article and Find Full Text PDF

We provide here the first bottom-up review of the lived experience of mental disorders in adolescents co-designed, co-conducted and co-written by experts by experience and academics. We screened first-person accounts within and outside the medical field, and discussed them in collaborative workshops involving numerous experts by experience - representing different genders, ethnic and cultural backgrounds, and continents - and their family members and carers. Subsequently, the material was enriched by phenomenologically informed perspectives and shared with all collaborators.

View Article and Find Full Text PDF

The human hand possesses both consolidated motor skills and remarkable flexibility in adapting to ongoing task demands. However, the underlying mechanisms by which the brain balances stability and flexibility remain unknown. In the absence of external input or behavior, spontaneous (intrinsic) brain connectivity is thought to represent a prior of stored memories.

View Article and Find Full Text PDF

We report here the first dual inhibitors of brain carbonic anhydrases (CAs) and monoamine oxidase-B (MAO-B) for the management of Alzheimer's disease. Classical CA inhibitors (CAIs) such as methazolamide prevent amyloid-β-peptide (Aβ)-induced overproduction of reactive oxygen species (ROS) and mitochondrial dysfunction. MAO-B is also implicated in ROS production, cholinergic system disruption, and amyloid plaque formation.

View Article and Find Full Text PDF

Effect of Polyplex Size on Penetration into Tumor Spheroids.

Mol Pharm

November 2023

Department of Pharmaceutical Sciences, Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University 99, 3508 TB Utrecht, The Netherlands.

Ovarian cancer is one of the most lethal gynecological cancers in the world. In recent years, nucleic acid (NA)-based formulations have been shown to be promising treatments for ovarian cancer, including tumor nodules. However, gene therapy is not that far advanced in clinical reality due to unfavorable physicochemical properties of the NAs, such as high molecular weight, poor cellular uptake, rapid degradation by nucleases, etc.

View Article and Find Full Text PDF

We provide here the first bottom-up review of the lived experience of depression, co-written by experts by experience and academics. First-person accounts within and outside the medical field were screened and discussed in collaborative workshops involving numerous individuals with lived experience of depression, family members and carers, representing a global network of organizations. The material was enriched by phenomenologically informed perspectives and shared with all collaborators in a cloud-based system.

View Article and Find Full Text PDF

This study aimed at investigating (1) the cognitive and motor predictors of divergent movement ability (DMA) in childhood and (2) the role of sport and enriched physical education (PE) experience. Participants were 165 fifth graders, aged 10-11 years, with different histories (onset and duration) of participation in enriched PE. They were assessed in cognitive/attentional and motor/sport skills and active play/sport habits at baseline, and six months later in DMA.

View Article and Find Full Text PDF

This study seeks to further our understanding of the factors associated with adolescent athletes and disordered eating, by expanding current research into a less-explored eating disorder known as orthorexia. The aim of the study is to explore the impact of parents' relationships and emotional regulation on the orthorexia nervosa (ON) tendencies of adolescent athletes. The participants were 303 adolescents, ranging from 15 to 17 years old, of which 139 participated in competitive sport, and 164 did not.

View Article and Find Full Text PDF

Perinatal diagnosis of congenital urogenital sinus abnormality.

Congenit Anom (Kyoto)

September 2023

Maternal and Child Health Department, Neonatal Intensive Care Unit, Pescara Public Hospital, Pescara, Italy.

Anomalies of the urogenital sinus, which is a transient feature of the early human embryological development, are rare birth defects. Urogenital sinus abnormalities commonly present as pelvic masses, hydrometrocolpos, or ambiguous genitalia and most commonly occur within the context of congenital adrenal hyperplasia. Anomalies of the urogenital sinus requires surgical repair.

View Article and Find Full Text PDF

A New Generation of IMiDs as Treatments for Neuroinflammatory and Neurodegenerative Disorders.

Biomolecules

April 2023

Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., NIH, Baltimore, MD 21224, USA.

The immunomodulatory imide drug (IMiD) class, which includes the founding drug member thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically improved the clinical treatment of specific cancers, such as multiple myeloma, and it combines potent anticancer and anti-inflammatory actions. These actions, in large part, are mediated by IMiD binding to the human protein cereblon that forms a critical component of the E3 ubiquitin ligase complex. This complex ubiquitinates and thereby regulates the levels of multiple endogenous proteins.

View Article and Find Full Text PDF

The study investigated the emergence of toddlers' regulatory strategies in aversive contexts. Forty-two toddlers were observed at 24 and 30 months of age using two paradigms designed to elicit fear and anger. We examined toddlers' use of regulatory strategies at these two stages of life regarding the frequency of self-versus other-oriented strategies and of reactive versus more controlled behaviors.

View Article and Find Full Text PDF

Purpose: Recently, new MRI systems working at magnetic field below 10 mT (Very and Ultra Low Field regime) have been developed, showing improved T1-contrast in projected 2D maps (i.e. images without slice selection).

View Article and Find Full Text PDF

Proteomic Signature and mRNA Expression in Hippocampus of SAMP8 and SAMR1 Mice during Aging.

Int J Mol Sci

December 2022

Drug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.

Aging is a complex process often accompanied by cognitive decline that represents a risk factor for many neurodegenerative disorders including Alzheimer's and Parkinson's disease. The molecular mechanisms involved in age-related cognitive decline are not yet fully understood, although increased neuroinflammation is considered to play a significant role. In this study, we characterized a proteomic view of the hippocampus of the senescence-accelerated mouse prone-8 (SAMP8), a model of enhanced senescence, in comparison with the senescence-accelerated-resistant mouse (SAMR1), a model of normal aging.

View Article and Find Full Text PDF

Hot topics in renal cancer pathology: implications for clinical management.

Expert Rev Anticancer Ther

December 2022

Department of Medical, Oral and Biotechnological Science, "Ss. Annunziata" Hospital Urology Unit, "G. d'Annunzio" University of Chieti and Pescara, Chieti, Italy.

Article Synopsis
  • The updated EAU Guidelines recommend adjuvant pembrolizumab for high-risk operable clear cell Renal Cell Carcinoma (ccRCC) but raise concerns about potential overtreatment and undertreatment of patients based on their risk levels.
  • The review highlights challenges in accurately identifying high-risk tumors due to interobserver variability among pathologists and discusses the need for better prognostic assessment systems.
  • It suggests that molecular biomarkers may improve patient prognostication in the future by helping to better identify those with a more severe prognosis.
View Article and Find Full Text PDF

A developmental outlook on the role of cognition and emotions in youth volleyball and artistic gymnastics.

Front Psychol

August 2022

Section of Movement Sciences, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Developmental and cognitive psychology recently started to take an interest in the sports domain, exploring the role of either cognitive functions or emotions in youth sport. However, to the extent that cognition and emotions are inextricably linked, studying them jointly from a developmental perspective could inform on their interplay in determining performance in different sports. This research examined the role of general cognitive abilities, attentional style, and emotions (controlling for age and experience), in predicting performance in youth volleyball and artistic gymnastics.

View Article and Find Full Text PDF