805 results match your criteria: "University hospitals of Derby and Burton[Affiliation]"

Article Synopsis
  • The guidelines are created by the British Gynaecological Cancer Society and British Menopause Society to help healthcare professionals support women treated for gynaecological cancer, especially regarding menopausal symptoms that can affect life quality.* -
  • Cancer treatments like surgery, radiotherapy, and chemotherapy can impact hormonal function, and the guidelines discuss the use of hormone replacement therapy (HRT) based on cancer type and when it should start post-treatment.* -
  • The document also highlights the effectiveness and safety of vaginal estrogens for urogenital symptoms and reviews alternative treatments to HRT, including both medication and lifestyle approaches.*
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Article Synopsis
  • - Desmoid-type fibromatosis is a rare tumor that forms in deep soft tissues and doesn't spread to other parts of the body; the case revolves around a 78-year-old male with this condition found incidentally in the abdomen.
  • - Initial imaging revealed a large mass in the abdomen, leading to a successful surgery to remove the tumor and part of the small intestine, which confirmed the diagnosis of primary desmoid-type fibromatosis.
  • - Even after clear removal, the patient experienced a recurrence of the tumor 17 months later, necessitating another surgery, with a smooth recovery reported post-operation.
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Premedication for less invasive surfactant administration: a narrative review.

Arch Dis Child Fetal Neonatal Ed

October 2024

Neonatal Medicine, Chelsea and Westminster Healthcare NHS Trust, London, UK.

Article Synopsis
  • - Less invasive surfactant administration (LISA) is gaining traction for treating respiratory distress syndrome in preterm infants who are breathing on their own.
  • - The best ways to manage pain and discomfort during LISA, whether through medication or other methods, are still uncertain, leading to inconsistent practices among healthcare providers.
  • - This article aims to highlight the current understanding of LISA and identify where more research is needed regarding premedication options before the procedure.
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The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study.

Am J Nephrol

October 2024

Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.

Article Synopsis
  • The study evaluates risks associated with Chronic Kidney Disease (CKD) across different primary renal diseases using data from a UK cohort of nearly 3,000 adults.
  • It found that over a median follow-up of about 49 months, many participants experienced kidney failure or death, with significant differences in risk based on the primary renal diagnosis (PRD), even after adjusting for factors like age and blood pressure.
  • The research highlights that while eGFR is a reliable predictor of kidney outcomes, the effectiveness of albuminuria (uACR) as a predictive marker varies greatly depending on the type of kidney disease, suggesting that personalized treatment strategies are essential in CKD management.
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Outcomes for centenarian patients admitted with orthopaedic trauma.

Surgeon

December 2024

University Hospitals of Derby and Burton Foundation Trust, United Kingdom; Research Institute, University of Wolverhampton, United Kingdom. Electronic address:

Introduction: The United Kingdom (UK) and world's population is aging with patients living longer, often with many co-morbidities. It is expected that patients of extreme old age would have poor outcomes following trauma; however, this assumption is not clearly evidenced. This study aims to present the outcomes of patients aged 100 or older admitted to a single hospital trust following admission for orthopaedic trauma.

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Introduction: The aim of this study was to investigate comparative outcomes of laparoscopic and open repair for peptic ulcer perforation (PUP).

Methods: A PRISMA-compliant systematic review with a PROSPERO-registered protocol (registration number CRD42024529286) was conducted. All randomised controlled trials (RCTs) involving PUP patients managed by laparoscopic or open repair were identified and their risk of bias assessed.

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Introduction: Consent forms play an active role in the consent process with generic, handwritten consent forms (GCF) often the standard across the National Health Service. Increasingly, procedure-specific consent forms (PSCF) are being used as an alternative. However, concerns remain about whether they meet the standard for consent.

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Article Synopsis
  • - Stevens-Johnson syndrome (SJS) is a severe condition that leads to severe skin and mucous membrane damage, marked by skin cell death and peeling.
  • - The case report focuses on a young adult who developed atypical SJS as a complication of an infection, highlighting its rarity.
  • - The goal is to expand awareness and knowledge about atypical SJS among healthcare professionals, especially in cases that present with mucosal rashes linked to infections.
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Glucagon-like Peptide-1 Receptor Agonists: New Evidence of Kidney and Cardiovascular Protection From the FLOW and SELECT Trials.

Am J Kidney Dis

January 2025

Centre for Kidney Research and Innovation, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom; University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom.

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Aims/hypothesis: People with diabetes-related foot ulcers (DFUs) have high mortality rates. This analysis assesses the impact of selected risk factors on short-term mortality using a population registered in the National Diabetes Foot Care Audit (NDFA).

Methods: Mortality rates at 12, 26 and 52 weeks was assessed in people with a new DFU registered by a specialist diabetes footcare service in the NDFA in England and Wales between April 2017 and March 2022.

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Well-leg compartment syndrome is a rare and severe complication that occurs after prolonged surgery in the lithotomy position. This review outlines the presentation, diagnosis, and management of well-leg compartment syndrome after colorectal surgery. A comprehensive and systematic search of various electronic databases was conducted.

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Background: Gastro-oesophageal reflux (GOR) affects nearly half of infants. Parents play a crucial role in management but more understanding of their attitudes and experiences is needed to inform future education, support and research. This study aims to explore parental experiences, attitudes and understanding of the symptoms, diagnosis and management of infant GOR.

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Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia.

J Infect

November 2024

National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, UK; Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Objectives: We aimed to determine the prevalence of and risk factors for nasopharyngeal and oral pneumococcal carriage in adults with community-acquired pneumonia (CAP), and the relationship between carried and disease-causing serotypes.

Methods: Between 2016 and 2018, nasopharyngeal swabs, oral-fluid, and urine were collected from hospitalised adults recruited into a prospective cohort study of CAP. Pneumococcal carriage was detected by semi-quantitative real-time PCR of direct and culture-enriched nasopharyngeal swabs and culture-enriched oral-fluid.

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Introduction: Computed Tomography (CT) chest, abdomen and pelvis research demonstrates a relationship between vertical phantom positioning and radiation dose. Moving the phantom closer or further from the x-ray source results in magnification or minimisation of the localiser. As automatic tube current modulation (ATCM) algorithms use localisers to estimate patient size and calculate required tube current, magnification or minimisation results in the incorrect provision of radiation dose.

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Cryptic population structure and insecticide resistance in Anopheles gambiae from the southern Democratic Republic of Congo.

Sci Rep

September 2024

Unit of Entomology, Department of Parasitology, Institut National de Recherche Biomédicale, 5345 Avenue De La Démocratie, Gombe, Kinshasa, République Démocratique du Congo.

Article Synopsis
  • The Democratic Republic of Congo has a big problem with malaria, and it's important to know how mosquitoes that spread it are affected by insecticides, especially since they mainly use treated nets to fight the disease.
  • Scientists studied mosquitoes from three different areas in southern Congo and found that many of these mosquitoes are becoming resistant to the insecticides used on the nets, especially in the Kimpese area.
  • By looking at the genetic makeup of these mosquitoes, they discovered differences between some populations, suggesting that resistance is connected to certain genes, and a specific gene in Kimpese might be a key factor for understanding this resistance better.
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Introduction: Digital surgical wound monitoring for patients at home is becoming an increasingly common method of wound follow-up. This regular monitoring improves patient outcomes by detecting wound complications early and enabling treatment to start before complications worsen. However, reviewing the digital data creates a new and additional workload for staff.

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Objectives: This study aimed to understand the lived experiences of patients on the anterior cruciate ligament reconstruction (ACLR) pathway up to 3 months before, 3 months after and 1 year after surgery. Study objectives were to explore (1) patient experiences of preoperative and postoperative treatment, (2) views of/involvement in prehabilitation and (3) sources and consistency of healthcare advice.

Design: Semi-structured interviews analysed using reflexive thematic analysis.

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Background: Although one objective of NHS 111 is to ease the strain on urgent and emergency care services, studies suggest the telephone triage service may be contributing to increased demand. Moreover, while parents and caregivers generally find NHS 111 satisfactory, concerns exist about its integration with the healthcare system and the appropriateness of advice. This study aimed to analyse the advice provided in NHS 111 calls, the duration between the call and ED attendance, and the outcomes of such attendances made by children and young people (C&YP).

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Birth tourism, the practice of a woman travelling out of her country of residence to another country to give birth, is common globally. Despite this, there is limited literature on the motivations and experiences of women who gave birth abroad. This study aims to address this gap by seeking to understand the motivations for and experiences of childbirth abroad among Nigerian women.

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Article Synopsis
  • The study investigates the management of primary aneurysmal bone cysts (ABCs), using methods like comprehensive curettage, hydrogen peroxide lavage, and non-vascularized strut fibular grafting, analyzed through 20 cases mostly involving young males.
  • Results showed a high average Musculoskeletal Tumor Society (MSTS) score of 91.55%, reflecting positive functional outcomes, with non-vascularized fibular grafts providing effective stabilization and quicker recovery.
  • The findings support the proposed treatment approach as a reliable option for ABC management, emphasizing improved patient outcomes and functional recovery while considering factors like age and lesion characteristics.
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Background: The efficacy and safety of endovascular thrombectomy (EVT) beyond 6 hours from stroke onset for patients with large vessel occlusion (LVO) selected without CT perfusion(CTP) or MR imaging(MRI) is undetermined. We conducted a systematic review and meta-analysis of the current literature comparing outcomes for late presenting patients with LVO treated by best medical management (BMM) with those selected for EVT based only on non-contrast CT(NCCT)/CT angiography(CTA) (without CTP or MRI).

Methods: PRISMA guidelines were employed.

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Introduction: The international recruitment of healthcare workers remains a UK strategy to manage workforce gaps and maintain service delivery. Although not a new phenomenon, this has been exacerbated by chronic shortages. There is a need to profile the current international recruits and identify individual motivators to understand the opportunities for future recruitment and retention initiatives.

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Background: Antiretroviral therapy (ART) use during pregnancy is essential to prevent vertical transmission of HIV, but it may also increase the risk of adverse birth outcomes. This study investigated the impact of both maternal HIV infection and the timing of ART initiation on birth outcomes in women living with HIV in South Africa.

Methods: This secondary data analysis examined the dataset from an earlier cohort study involving 1709 pregnant women living with HIV who delivered their babies at three major maternity centres in the Eastern Cape province of South Africa between September 2015 and May 2018.

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