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Infrared microspectroscopy to elucidate the underlying biomolecular mechanisms of FLASH radiotherapy.

Radiother Oncol

July 2024

Laboratory of Radiation Oncology, Radiation Oncology Service and Oncology Department, Lausanne University Hospital and University of Lausanne, 1066, Lausanne, Switzerland; Radiotherapy and Radiobiology sector, Radiation Therapy service, University hospital of Geneva (Current address), 1205, Geneva, Switzerland.

Background: FLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue. The biological studies showed the potential of FLASH-RT to revolutionize radiotherapy cancer treatments. However, the complex biological basis of FLASH-RT is not fully known yet.

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