Synthesis of new dihydropyrimidine derivatives and investigation of their antimicrobial and DNA gyrase inhibitory activities.

Quinolone antibiotics are known for their antibacterial activity by inhibiting the enzyme DNA gyrase. Inspired by their mechanism, new compounds combining 1,4-dihydropyrimidine, a quinolone isostere, with pyridine/pyrimidine rings were synthesized. These derivatives showed antibacterial effects, likely through DNA gyrase inhibition, as supported by molecular docking and dynamics simulations.

Multilocus Sequence Typing and Antimicrobial Susceptibility of Isolated from Foods Surveyed in Kosovo.

In the absence of data on the reporting of resistance to antibiotics, we sought to determine which clonal complexes (CCs)/sequence types (STs) circulate in the food chain in Kosovo and to determine their antibiogram profiles to a panel of 18 antibiotics. From a total of 114 isolates, 21 different typical STs were identified by multilocus sequence typing (MLST). Each isolate derived from the food categories was subjected to tests to verify its susceptibility to the selected antibiotics according to the designed Sensititre GPN3F panel.

The Role of Law Enforcement Mechanisms in the Care of Occupational Health and Safety in the Workplace of Health Professionals in Kosovo.

Background: Workplace health and safety are critical concerns for healthcare professionals, who are often exposed to various occupational hazards.

Objective: The aim of the study was to analyze the effectiveness and impact of law enforcement mechanisms in ensuring occupational health and safety for healthcare professionals in Kosovo.

Methods: Consist in conduct research on the role of law enforcement mechanisms in ensuring the occupational health and safety of healthcare professionals in Kosovo, using a qualitative methodology with questionnaires targeting the Health Inspectorate and Labor Inspectorate.

Challenges of Occupational Health and Safety Management in Healthcare Institutions in Kosovo.

Background: Occupational health and safety (OHS) in healthcare institutions are crucial for the well-being of healthcare workers who are exposed to numerous risks in their working environment. In Kosovo, where healthcare institutions operate under resource constraints, understanding the challenges of OHS management challenges is vital for developing effective strategies.

Objective: This study aims to explore the challenges of OHS management in Kosovo's healthcare system, focusing on three levels of healthcare provision in both the public and private sectors.

Quality of Life, Depression, and Psychological Distress Among Patients With Rheumatoid Arthritis Treated With Biologics.

The introduction of biologics has improved the management of rheumatoid arthritis (RA), enhancing disease control and quality of life for patients. However, despite these advancements, some individuals still experience distress and depression due to the effects of treatment and concerns about the outcomes of biologic therapy. This study aimed to evaluate the current quality of life, level of distress, and depression among RA patients treated with biologics, which could serve as a basis for intervention.

Molecular Characterization of in the Food Chain of the Republic of Kosovo from 2016 to 2022.

The present study describes the genetic characterization of strains found in the Republic of Kosovo's food chain. From 2016 to 2022, 995 samples were collected. Overall, 648 samples were from ready-to-eat (RTE) food products, 281 from food products consumed cooked (FPCC), 60 from raw materials, and 6 from environmental samples.

Design, synthesis, biological evaluation, and molecular modeling simulations of new phthalazine-1,4-dione derivatives as anti-Alzheimer's agents.

The development of targeted phthalazine-1,4-dione acetylcholinesterase (AChE) inhibitors for treating Alzheimer's disease involved the synthesis of 32 compounds via a multistage process. Various analytical techniques confirmed the compounds' identities. Thirteen compounds were found to inhibit AChE by more than 50% without affecting butyrylcholinesterase (BChE).

Dual career through the eyes of university student-athletes in the Republic of Kosovo.

Introduction: The successful combination of a sports career and education, known as the dual career, requires cooperation and a multi-dimensional approach. Although extensive research has been conducted on dual career programs and services in developed countries, there is limited information available on the dual-career phenomenon in developing countries. This study aimed to explore the dual career experiences of university student-athletes in the Republic of Kosovo.

Design and synthesis of phenoxy methyl-oxadiazole compounds against Alzheimer's disease.

This study examines the synthesis and evaluation of 11 newly developed compounds as potential anti-Alzheimer's agents that occur via cholinesterase and β-secretase inhibition. The compounds were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using the modified Ellman method. The results showed that several compounds exhibited significant inhibition of AChE, particularly compounds 6d, 7a, and 7e, which demonstrated high inhibitory activity at lower concentrations, with IC values of 0.

New -(1,3,4-thiadiazole-2-yl)acetamide derivatives as human carbonic anhydrase I and II and acetylcholinesterase inhibitors.

Various carbonic anhydrase (CA) enzyme isoforms are known today. In addition to the use of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other specific isoforms of CA was reported to have clinical benefits in cancers. In this study, two groups of 1,3,4-thiadiazole derivatives were designed and synthesized to act as human CA I and II (CA I and CA II) inhibitors.

Modeling of soil moisture movement and wetting behavior under point-source trickle irrigation.

The design and selection of ideal emitter discharge rates can be aided by accurate information regarding the wetted soil pattern under surface drip irrigation. The current field investigation was conducted in an apple orchard in SKUAST- Kashmir, Jammu and Kashmir, a Union Territory of India, during 2017-2019. The objective of the experiment was to examine the movement of moisture over time and assess the extent of wetting in both horizontal and vertical directions under point source drip irrigation with discharge rates of 2, 4, and 8 L h.

Anaphylaxis Caused by Taking Pantoprazole: Case Series.

Introduction: Pantoprazole is one of the most widely used proton pump inhibitors, but anaphylaxis occurs rarely during its use. The purpose of reporting these two cases is to show that pantoprazole is not a drug without problems; it can also cause anaphylactic reactions.

Cases Description: A 42-year-old woman presented to the emergency department due to dyspeptic complaints.

Novel oxadiazole-thiadiazole derivatives: synthesis, biological evaluation, and studies.

In the search for new anticancer agents, we synthesized a new series of thiazole derivatives carried on thiadiazole-oxadiazole hybrid. Final compounds () were analyzed H NMR, C NMR, and HRMS. The pharmacokinetic profile of the targeted compounds was predicted calculations.

Assessment of correlation between clinical, radiographic, microbiological, and histopathological examinations in identification of pulpal diseases - a single-centre study.

Aim: This study aimed to analyse the presence of pulpitis using different techniques and compare the findings of the various examination methods.

Methods: A total of 108 patients were enrolled and randomly divided into two groups: 56 patients whose pulp samples were sent for histopathological analysis and 52 patients whose samples were sent for microbiological analysis. All participants underwent endodontic procedures, with clinical evaluation and assessment using periapical radiography.

Soil erosion control from trash residues at varying land slopes under simulated rainfall conditions.

Trash mulches are remarkably effective in preventing soil erosion, reducing runoff-sediment transport-erosion, and increasing infiltration. The study was carried out to observe the sediment outflow from sugar cane leaf (trash) mulch treatments at selected land slopes under simulated rainfall conditions using a rainfall simulator of size 10 m × 1.2 m × 0.

Facial Cellulitis Caused by in an Immunocompetent Patient: A Rare Case Report.

Background: Candida cellulitis is a rare disease, primarily reported in immunocompromised patients. Atypical Candida spp. infections are increasing, largely due to the growing number of immunocompromised patients.

Forecasting of stage-discharge in a non-perennial river using machine learning with gamma test.

Knowledge of the stage-discharge rating curve is useful in designing and planning flood warnings; thus, developing a reliable stage-discharge rating curve is a fundamental and crucial component of water resource system engineering. Since the continuous measurement is often impossible, the stage-discharge relationship is generally used in natural streams to estimate discharge. This paper aims to optimize the rating curve using a generalized reduced gradient (GRG) solver and the test the accuracy and applicability of the hybridized linear regression (LR) with other machine learning techniques, namely, linear regression-random subspace (LR-RSS), linear regression-reduced error pruning tree (LR-REPTree), linear regression-support vector machine (LR-SVM) and linear regression-M5 pruned (LR-M5P) models.

More on the Use of Goggles and Snorkel in Learning-to-Swim: New Results for Children Fear of Water.

In recent research, we found that the use of goggles and snorkel benefited non-swimmers with fear of water in a learn-to-swim program. Our purpose in study was to examine the effects of using goggles and snorkel during a learn-to-swim program on the aquatic skills of young non-swimmers fear of water. We modelled this research on our prior study.

A residue management machine for chopping paddy residues in combine harvested paddy field.

Nowadays, Combine Harvesters are the most commonly used device for harvesting crops; as a result, a large amount of plant material and crop residue is concentrated into a narrow band of plant material that exits the combine, challenging the residue management task. This paper aims to develop a crop residue management machine that can chop paddy residues and mix them with the soil of the combined harvested paddy field. For this purpose, two important units are attached to the developed machine: the chopping and incorporation units.

Microbiological aspects of the traditional Travnik/Vlašić cheese manufactured in Bosnia and Herzegovina.

The microbiological aspects of traditional Travnik/Vlašić cheese was investigated. The cheese was made traditionally, from raw sheep milk at three small farms (A, B, C) on Mountain Vlašić. The microbiological quality of the cheese was examined during three stages of ripening (5, 30, 60 days) and followed during three seasons (3 years).

The relationship between executive functions and writing in children: a systematic review.

Writing is a complex task that is acquired in the early primary school years and continues to develop through adolescence and beyond. Studying the cognitive processes that support writing skills during the acquisition phase may be crucial to support this complex skill especially in less-skilled writers. Executive Functions (EF) could have an important role as they are high cognitive control processes that allow individuals to control and plan thoughts and actions in order to achieve a goal.

Injury incidence and risk factors in youth soccer players: a systematic literature review. Part II: Intrinsic and extrinsic risk factors.

Injury is defined as a complex phenomenon determined by the non-linear interaction of several intrinsic and extrinsic factors. The objective of the present study was to perform a systematic literature review on the injury risk factors in young soccer players. After electronic database searching, articles in line with the inclusion criteria were selected for the systematic review.

Injury incidence and risk factors in youth soccer players: a systematic literature review. Part I: epidemiological analysis.

The analysis of the epidemiological data and the risk factors underlying injuries is crucial to promote prevention strategies in young soccer players. The objective of the present study was to perform a systematic literature review on the epidemiological data, described in the first part, and injury risk factors, presented in the second part. After electronic database searching, articles in line with the inclusion criteria were selected for the systematic review.

Challenges in Collecting and Reporting Health Statistics in Kosovo.

Background: Statistical data play a crucial role in research, planning and decision making in the health system, especially in the formulation and implementation of health policies. Health policy, adequate health legislation and sustainable financing of the health system remain serious challenges for countries in transition and especially for the Republic of Kosovo.

Objective: To analyze the challenges of collection, accuracy and accurate reporting and the impact of the accuracy of these health statistics on the creation of appropriate public health policies in Kosovo.