Multishelled Hollow Covalent Organic Framework Nanospheres for Stable Potassium Storage.

Multishelled hollow covalent organic framework nanospheres (MH-COFs) with at least two shells integrate the merits of the porous crystalline covalent organic framework (COF) matrix with the complex hollow architecture, which can motivate new functions for exceptional performance. However, the fabrication of MH-COFs is still uncultivated and remains a formidable challenge. Herein, we reported a facile template-free protocol for the general synthesis of different MH-COFs by controlling the simultaneous processes of surface crystallization and core etching of the crystalline-inhomogeneity nanospheres of COFs precursor.

High carbon fixation during thermal stratification period in a subtropical periodic stratified reservoir: Evidences from RDOC conversion efficiency driven by MCP.

Recalcitrant dissolved organic carbon (RDOC) generated by microbial carbon pumps (MCP) significantly influences terrestrial waters and may contribute to the formation of a long-lasting carbon sink. However, there remains a notable lack of research on the carbon fixation processes and efficiencies of MCP in response to changes in thermal structure within subtropical reservoirs. In this study, we examined the effectiveness of transforming dissolved inorganic carbon (DIC) into dissolved organic carbon (DOC) and subsequently into RDOC through the influence of MCP at various water depths during both Thermal stratification (TS) periods and Mixing (MX) period in the Dalongdong (DLD) Reservoir, a representative subtropical reservoir.

Biophysical and Morphological Cell Features Retrieved by Digital Holographic Microscopy Correlate with Drug-Induced Changes in Cell Migration Behavior.

Quantitative analysis of cancer cell migration is critical for developing effective therapies to curb cancer metastasis. However, traditional methods are time-consuming and labor-intensive and lack quantitative capabilities. Cell volume change, a key physiological indicator of cell migration, is directly linked to phase change.

Cucurbitacin I Reverses Tumor-Associated Macrophage Polarization to Affect Cancer Cell Metastasis.

The tumor microenvironment plays a critical role in tumor progression and immune regulation. As one of the most important components of the tumor microenvironment, macrophages have become a new therapeutic target for inhibiting tumor progression. Despite the well-documented anticancer activity of cucurbitacin I, its effect on macrophages remains unclear.

A meteorologically adjusted ensemble Kalman filter approach for inversing daily emissions: A case study in the Pearl River Delta, China.

The conventional Ensemble Kalman filter (EnKF), which is now widely used to calibrate emission inventories and to improve air quality simulations, is susceptible to simulation errors of meteorological inputs, making accurate updates of high temporal-resolution emission inventories challenging. In this study, we developed a novel meteorologically adjusted inversion method (MAEInv) based on the EnKF to improve daily emission estimations. The new method combines sensitivity analysis and bias correction to alleviate the inversion biases caused by errors of meteorological inputs.

A specialized bone marrow microenvironment for fetal haematopoiesis.

In adult mammalian bone marrow (BM), vascular endothelial cells and perivascular reticular cells control the function of haematopoietic stem and progenitor cells (HSPCs). During fetal development, the mechanisms regulating the de novo haematopoietic cell colonization of BM remain largely unknown. Here, we show that fetal and adult BM exhibit fundamental differences in cellular composition and molecular interactions by single cell RNA sequencing.

Using AI chatbots to provide self-help depression interventions for university students: A randomized trial of effectiveness.

Background: Depression impacts the lives of a large number of university students. Mobile-based therapy chatbots are increasingly being used to help young adults who suffer from depression. However, previous trials have short follow-up periods.

Preparation and evaluation of an injectable curcumin loaded chitosan/hydroxyapatite cement.

Curcumin (Cur) is an active ingredient of Curcuma longa. Cur has many pharmacological effects, such as anti-inflammation, anti-oxidation, anticoagulation, hypolipidemic, anti-angiogenesis and anti-cancer. An injectable curcumin loaded chitosan/hydroxyapatite bone cement (Cur-CS/HA) was prepared as a bone scaffold and drug delivery.