4,108 results match your criteria: "University Street[Affiliation]"
BMC Urol
December 2024
Prokarium Ltd, 2 Royal College St, London, NW1 0NH, UK.
Background: Urine biomarkers are crucial for monitoring patient responses in treating urological pathologies, including non-muscle invasive bladder cancer (NMIBC). Yet, analysing urine biomarkers poses several challenges, including ensuring specimen stability during transportation and analytical processing. This prospective feasibility study aimed to investigate how urinary leukocytes and proteins are impacted by storing and refrigerating urine.
View Article and Find Full Text PDFDysphagia
December 2024
Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001 12e avenue Nord, Sherbrooke, QC, J1H 5N4, Canada.
Oculopharyngeal muscular dystrophy (OPMD) is a rare late-onset muscle disease with progressive dysphagia as a major symptom. The Dysphagiameter is a newly developed patient-reported outcome measure (PROM) to assess the severity of dysphagia and its impact in patients with OPMD. This article reports on item reduction and a first assessment of the Dysphagiameter's psychometrics properties, in a French and English-speaking population of individuals with OPMD.
View Article and Find Full Text PDFEur J Oncol Nurs
December 2024
İzmir Bakırçay University Health Sciences of Faculty, Oncology Nursing Department, Gazi Mustafa Kemal District, Kaynaklar Caddesi Seyrek, Menemen, İzmir, Türkiye. Electronic address:
Purpose: This study aims to examine the effects of virtual reality applications on pain, anxiety, and vital signs during port catheter needle insertion in adult cancer patients.
Methods: The research followed a randomized controlled design as intervention and control groups. In the intervention group, patients received virtual reality sessions with five images in addition to routine procedures during the port catheter needle insertion.
Int Immunopharmacol
December 2024
Department of Nephrology, Shanxi Provincial People's Hospital, The Fifth Clinical Medical College of Shanxi Medical University, 29 Shuang Ta East Street, Taiyuan 030012, China. Electronic address:
Background: Effective therapeutic approaches for the treatment of diabetic nephropathy (DN) with irreversible deterioration of renal function are currently lacking. In this study, we aimed to investigate the ability of the glucagon-likepeptide-1 (GLP-1)/ gastric inhibitory polypeptide (GIP) dual agonist, tirzepatide to alleviate DN in mice and its underlying mechanisms.
Methods: We investigated the reno-protective effect of semaglutide and tirzepatide in a mouse model of DN, an insulin-treated positive control group was also included.
Sci Data
December 2024
Rothamsted Research, Protecting Crops and the Environment, Harpenden, UK.
Alopecurus aequalis is a winter annual or short-lived perennial bunchgrass which has in recent years emerged as the dominant agricultural weed of barley and wheat in certain regions of China and Japan, causing significant yield losses. Its robust tillering capacity and high fecundity, combined with the development of both target and non-target-site resistance to herbicides means it is a formidable challenge to food security. Here we report on a chromosome-scale assembly of A.
View Article and Find Full Text PDFPlant J
December 2024
Newe Yaar Research Center, Agricultural Research Organization, P. O. Box 1021, Ramat Yishay, 30095, Israel.
Volatile phenylpropenes comprise one of the largest groups of plant phenylalanine-derived volatiles that not only possess ecological roles but also exhibit numerous pharmacological activities. Despite their wide distribution in the plant kingdom, biosynthesis of only a small subset of these compounds has been discovered. Here, we elucidated yet unknown steps in the biosynthesis of isoelemicin and elemicin using carrot (Daucus carota subsp.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 10, 1 December Square, 410073 Oradea, Romania.
Bone regeneration is a highly dynamic and complex process that involves hematopoietic stem cells and mesenchymal cells, collagen fibers, non-collagenous proteins and biomolecules from extracellular matrices, and different cytokines and immune cells, as well as growth factors and hormones. Some phytochemicals due to antioxidant and anti-inflammatory effects can modulate the bone signaling pathways and improve bone healing and thus can be a good candidate for osteoregeneration. The aim of this study was to analyze the impact of L.
View Article and Find Full Text PDFPolymers (Basel)
November 2024
Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16, University Street, 700115 Iasi, Romania.
New quaternary ammonium derivatives (quats) based on apple pectin (PA) were synthesized by the chemical modification of native polysaccharides with various quaternization mixtures containing epichlorohydrin (ECH) and a tertiary amine. Pectin derivatives (QPAs) were studied by elemental analysis, conductometric titration, Fourier-transform infrared spectroscopy (FTIR), and C nuclear magnetic resonance (C NMR). Viscosity measurements enabled the evaluation of the viscosity average molar mass (M) for the unmodified polysaccharide, as well as its intrinsic viscosity ([η]) value.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Department of Electrical Measurements and Materials, Gheorghe Asachi Technical University, 700050 Iasi, Romania.
Colorectal cancer (CRC) remains a significant global health burden, necessitating a thorough understanding of prognostic and predictive factors to enhance patient outcomes. This systematic review aims to comprehensively evaluate prognostic and predictive determinants in CRC, encompassing both traditional and emerging biomarkers. A systematic search of major electronic databases was conducted to identify relevant studies published from 1995 up to 2024.
View Article and Find Full Text PDFSmall
December 2024
School of Materials Science and Engineering, Shandong University of Technology, Zibo, Shandong, 255000, P. R. China.
Developing antibacterial and biodegradable cellulose acetate (CA) membrane materials is one of the main challenges in multiple application fields. CA membrane materials are widely used in gas purification, water purification, and biomedical fields due to their environmental friendliness, high chemical and mechanical stability, excellent processability, and low cost. However, antibacterial modification of CA membrane materials to enhance their utilization value in the application process has always been the direction of researchers' efforts.
View Article and Find Full Text PDFAm J Transl Res
November 2024
Lower Extremity Division, Orthopedic Trauma Department, Honghui Hospital, Xi'an Jiaotong University Youyi East Road No. 555, Beilin District, Xi'an, Shaanxi, China.
Purpose: The stromal cell protein metalloproteinase 9 (MMP9), associated with extracellular matrix degradation and remodeling, promotes tumor invasion and metastasis and regulates cell adhesion molecule and cytokine activity. This study evaluated MMP9 in pan-cancer and screened for compounds and drug candidates that can inhibit it.
Methods: MMP9 expression in pan-cancer tissues was evaluated in a pan-cancer dataset from the University of California Santa Cruz database, along with the correlation between MMP9 and the tumor microenvironment (TME), RNA modification genes, and tumor mutation burden.
Eur Heart J
December 2024
Institute of Cardiovascular Science, University College London, Rayne Building-Room 228, 5 University Street, London WC1E 6JF, UK.
Anal Chem
December 2024
Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
Biomed Mater
December 2024
Mechanical Engineering, École de technologie supérieure, 1100 Notre dame Ouest, Montreal, Quebec, H3C 1K3, CANADA.
Despite their recognized potential for ischemic tissue repair, the clinical use of human mesenchymal stromal cells (hMSC) is limited by the poor viability of cells after injection and the variability of their paracrine function. In this study, we show how the choice of biomaterial scaffolds and the addition of cell preconditioning treatment can address these limitations and establish a proof-of-concept for cryopreservable hMSC-loaded microbeads. Injectable microbeads in chitosan, chitosan-gelatin, and alginate were produced using stirred emulsification to obtain a similar volume moment mean diameter (D[4,3]500 µm).
View Article and Find Full Text PDFBiomech Model Mechanobiol
December 2024
School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, 47907, IN, USA.
Cell migration via autologous chemotaxis in the presence of interstitial fluid flow is important in cancer metastasis and embryonic development. Despite significant recent progress, our understanding of flow-induced autologous chemotaxis of multicellular systems remains poor. The literature presents inconsistent findings regarding the effectiveness of collective autologous chemotaxis of densely packed cells under interstitial fluid flow.
View Article and Find Full Text PDFMol Metab
November 2024
Research Institute of the McGill University Health Centre, McGill University Health Centre, 1001 boulevard de Decarie, Montreal, QC, H4A 3J1, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, 1001 boulevard de Decarie, Montreal, QC, H4A 3J1, Canada; Integrated Program in Neuroscience, Department of Medicine, McGill University, Room 302 Irving Ludmer Building, 1033 Pine Ave. W. Montreal, QC, H3A 1A1, Canada. Electronic address:
Objective: Growth differentiation factor 15 (GDF15) acts on the receptor dimer of GDNF family receptor alpha-like (GFRAL) and Rearranged during transfection (RET). While Gfral-expressing cells are known to be present in the area postrema and nucleus of the solitary tract (AP/NTS) located in the brainstem, the presence of Gfral-expressing cells in other sites within the central nervous system and peripheral tissues is not been fully addressed. Our objective was to thoroughly investigate whether GFRAL is expressed in peripheral tissues and in brain sites different from the brainstem.
View Article and Find Full Text PDFPolymers (Basel)
November 2024
Department of Nutrition and Dietetics, Faculty of Pharmacy, Vasile Goldis Western University of Arad, Liviu Rebreanu Street, 86, 310045 Arad, Romania.
Life (Basel)
November 2024
Department of Morpho-Functional Sciences II, Discipline of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Int J Mol Sci
November 2024
Center for Research and Education in Nanobioengineering, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
The complexities inherent in drug development are multi-faceted and often hamper accuracy, speed and efficiency, thereby limiting success. This review explores how recent developments in machine learning (ML) are significantly impacting target-based drug discovery, particularly in small-molecule approaches. The Simplified Molecular Input Line Entry System (SMILES), which translates a chemical compound's three-dimensional structure into a string of symbols, is now widely used in drug design, mining, and repurposing.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Surgical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize the existing research on quercetin's potential health benefits, therapeutic properties, and effectiveness in disease prevention and treatment. In addition to evaluating quercetin's potential for drug development with fewer side effects and lower toxicity, this type of review attempts to collect scientific evidence addressing quercetin's roles as an antioxidant, anti-inflammatory, antibacterial, and anticancer agent. In the first part, we analyze various flavonoid compounds, focusing on their chemical structure, classification, and natural sources.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätstraße 19, 91054 Erlangen, Germany.
Animals (Basel)
November 2024
Department of Agricultural and Biological Engineering, Purdue University, 225 South University Street, West Lafayette, IN 47907, USA.
Determining ventilation rates in commercial animal buildings has been technically challenging. This study aimed to develop an innovative method and a ventilation model and provide new insights into animal building ventilation. A layer house with 46 fans was studied over six months.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Department II of Microscopic Morphology, Victor Babes University of Medicine and Pharmacy Timisoara, E. Murgu Square, No. 2, 300041 Timisoara, Romania.
Posterior retroperitoneal laparoscopic adrenalectomy (PRLA) has emerged as a revolutionary, minimally invasive technique for adrenal gland surgery, offering significant advantages over traditional open approaches. This narrative review aims to provide a comprehensive update on PRLA, focusing on its anatomical foundations, surgical technique, and clinical implications. We conducted an extensive review of the current literature and surgical practices to elucidate the key aspects of PRLA.
View Article and Find Full Text PDFDiagnostics (Basel)
November 2024
Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
Cardiac magnetic resonance (cMRI) imaging has recently become essential in cardiology. cMRI is widely recognized as the most reliable imaging technique for assessing the size and performance of the right ventricle. It allows for objective and functional cardiac tissue evaluations.
View Article and Find Full Text PDFClin Pract
November 2024
Department of Urology, Bihor Emergency Clinical County Hospital, 410169 Oradea, Romania.
: Radical cystectomy (RC) represents one of the most complex and morbid surgical procedures in the field of Urology. Extraperitoneal open RC has emerged as an alternative to the traditional transperitoneal approach for the treatment of muscle-invasive bladder cancer. Frailty is one of the most important risk factors for perioperative morbidity and mortality, and this category of patients can benefit the most from the extraperitoneal approach.
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