7,959 results match your criteria: "University Road.[Affiliation]"

Population Pharmacokinetics of Vancomycin in Intensive Care Patients with the Time-Varying Status of Temporary Mechanical Circulatory Support or Continuous Renal Replacement Therapy.

Infect Dis Ther

December 2024

Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan City, 701, Taiwan.

Article Synopsis
  • This study evaluates how vancomycin is processed in critically ill patients, particularly those undergoing continuous renal replacement therapy (CRRT) or temporary mechanical circulatory support (tMCS).
  • The research involved 25 patients and focused on how factors like serum creatinine and body weight influence drug clearance and distribution.
  • It concludes that vancomycin dosing should consider both renal function and body weight, suggesting modified initial and maintenance doses for patients on CRRT, while also noting that tMCS can complicate dosing adjustments due to altered drug clearance.
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Investigating stakeholders' perceptions of environmental protection fleets within the framework of policies designed to mitigate marine debris.

J Environ Manage

December 2024

Institute of Ocean Technology and Marine Affairs, National Cheng Kung University, 1 University Road, Tainan City, Taiwan. Electronic address:

Since 2017, Taiwan has established the "Marine Debris Management Platform" and has implemented various action plans to mitigate the problem of marine debris. This study focuses on the implementation plan for an environmentally friendly fleet within the proposed solutions. The study aims to analyze perspectives and perceptions regarding the role of the environmental fleet in marine waste recovery and subsequent disposal issues through semi-structured interviews with stakeholders.

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Background: In the United Kingdom, onsite religious services were halted during COVID-19 lockdowns, which were followed by various levels of restrictions on communal worship including social distancing, mandatory wearing of face masks, adequate ventilation and a ban on congregational singing and chanting. The aim of our study was to evaluate the impact of closures and changes within places of worship in response to the first lockdown in 2020, to assess the effect of the pandemic on religious practice and worshippers' wellbeing and religious coping.

Methods: Participants were regular worshippers in the UK, recruited through an online survey using convenience sampling.

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Late preterm and early term birth: Challenges and dilemmas in clinical practice.

Semin Fetal Neonatal Med

December 2024

University of Leicester, Department of Population Health Sciences, George Davies Centre, University Road, Leicester, LE1 7RH, United Kingdom. Electronic address:

The major focus of neonatal research for many years has been the smallest and most vulnerable infants born before 32 weeks of gestation. More recently it has become clear that a gradient of risk for adverse outcomes spans the whole spectrum of gestational age, from those born at the margins of viability, to those born close to their estimated date of delivery. Whilst effect sizes may be smaller for the more mature babies born late preterm and early term, the size of the problem is related to very large numbers with less severe difficulties, yet whose problems affect many domains of health, development and education, and may have impact across the whole life course.

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Monoterpene Hydroxy Lactones Isolated from sp. Microalga and Their Antibacterial and Antioxidant Activities.

Molecules

October 2024

CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

Two monoterpenoid lactones, loliolide () and -loliolide (), were isolated from the crude dichloromethane extract of a microalga, sp.). The structures of loliolide () and -loliolide () were elucidated by 1D and 2D NMR analysis, as well as a comparison of their H or/and C NMR data with those reported in the literature.

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Mycotoxin profiles and plumpness of Tritordeum grain after artificial spike inoculation with Fusarium culmorum W.G. Smith.

Int J Food Microbiol

January 2025

University of Natural Resources and Life Sciences, Vienna (BOKU), Department of Agrobiotechnology (IFA-Tulln), Institute of Bioanalytics and Agro-Metabolomics, Konrad-Lorenz-Strasse 20, 3430 Tulln an der Donau, Austria; Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland, United Kingdom.

The responses to artificial spike inoculation with Fusarium culmorum were compared in 11 Tritordeum lines, two durum wheat cultivars and one naked barley cultivar. Inoculation of Tritordeum spikes led to a significant decrease in spike weight, kernel weight per spike, and kernel weight (by 18, 28, and 16 %, respectively). Durum wheat responded most strongly to inoculation, particularly with regard to spike weight and kernel weight per spike (decrease of 42 % and 53 %, respectively).

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Variation in the intestinal bacterial community composition under different water temperature culture conditions in largemouth bass (Micropterus salmoides).

J Appl Microbiol

November 2024

Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Marine Sciences, Guangxi Academy of Sciences, No.98 Daling Road, Nanning 530007, P.R. China.

Aims: This study aimed to investigate the impact of temperature on the intestinal microbiota of largemouth bass using 16S rRNA gene amplicon sequencing, focusing on the under-explored role of abiotic factors in shaping the gut microbial community.

Methods And Results: Five water temperature groups (20.0 ± 0.

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Although phytoremediation is more economical when compared with traditional physical and chemical soil remediation methods, it remains very expensive when considering the substantial area of the contaminated field. If the quantity of harvested residues can be reduced after each phytoremediation cycle, the practicability and commercial implementation of this environment friendly method can be improved. In this study, cadmium excretion on the leaf surface of Festuca arundinacea was evaluated under various blue and red light conditions.

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Enhanced Performance of Lithium-Sulfur Batteries Using Construction Wastes: A Sustainable Approach to High-Loading Sulfur Cathodes.

ChemSusChem

November 2024

Department of Materials Science and Engineering, National Cheng Kung University, No.1, University Road, Tainan City, 70101, Taiwan.

Article Synopsis
  • * A major hurdle is the poor conductivity of sulfur cathodes, which can be improved through the use of conductive carbon materials to enhance sulfur loading and polysulfide retention.
  • * This study innovatively uses recycled materials, like quartz and shelf boards, coated with graphene to boost battery performance significantly, while also supporting green chemistry and reducing waste.
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Improvements for the solution of crack evolution using extended finite element method.

Sci Rep

November 2024

Department of Engineering, University of Exeter, Harrison Building, North Park Road, Exeter, EX4 4QF, United Kingdom.

It is demonstrated that the eXtended Finite Element Method (XFEM) is of remarkable efficiency in simulating crack evolution by eliminating the need for remeshing and refinement. In this paper, it is shown how to enhance the solution efficiency through a comprehensive mathematical investigation of the solution process using XFEM. A typical example is presented to illustrate the disparities in nodal displacements along the two symmetric faces of the crack resulting from the approximation of XFEM.

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A series of 8 trigonal planar, heavy alkaline earth (AE = Ca-Ba) metal complexes containing cyclic (alkyl)(amino)carbene (CAAC) ligands were prepared from AE bis(amide) species. Complexation can be achieved by first generating the free carbene or by direct addition of the free carbene, with the former route giving rise to unexpected mixed-amide AE complexes. The frontier molecular orbitals of the highly equatorial, 3-coordinate AE-CAAC species were also probed computationally, revealing the lowest unoccupied molecular orbital (LUMO) consisting predominantly of the π* system located on the carbene ligand.

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Invasive species are a significant driver of environmental change in social-ecological systems (SES) globally. Given that SES are inherently complex adaptive systems (CAS), they continuously reorganize themselves and adapt to change, including changes in ecological composition, as well as in associated lives and livelihoods. Decision-making on invasive species management in such systems can be contested and fraught with tradeoffs.

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Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3.

Chem Commun (Camb)

November 2024

Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK.

Histone deacetylase (HDAC) enzymes 1-3 exist in several corepressor complexes and are viable drug targets. To date, proteolysis targeting chimeras (PROTACs) designed to target HDAC1-3 typically exhibit the selective degradation of HDAC3. Herein, we report cereblon-recruiting PROTACs that degrade HDAC1 with selectivity over HDAC3.

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Fractional gradient optimized explainable convolutional neural network for Alzheimer's disease diagnosis.

Heliyon

October 2024

Future Technology Research Center, National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliu, Yunlin, 64002, Taiwan, Republic of China.

Alzheimer's is one of the brain syndromes that steadily affects the brain memory. The early stage of Alzheimer's disease (AD) is referred to as mild cognitive impairment (MCI), and the growth of Alzheimer's is not certain in patients with MCI. The premature detection of Alzheimer's is crucial for maintaining healthy brain function and avoiding memory loss.

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High-volume injections in Achilles tendinopathy: a systematic review.

Br Med Bull

December 2024

Department of Trauma and Orthopaedics Surgery, Faculty of Medicine and Psychology, University La Sapienza, Piazzale Aldo Moro 5, Roma, 00185, Italy.

Article Synopsis
  • Achilles tendinopathy (AT) is a common issue for runners, and high-volume injections (HVIs) may offer better management compared to traditional treatments like exercise and PRP injections.
  • A systematic review analyzed 10 studies involving 460 participants, finding that HVIs with corticosteroids led to both immediate and lasting improvements in ankle function and reduced tendon thickness.
  • While no adverse events were reported with HVI, more comprehensive studies are needed to confirm long-term efficacy and consistency in treatment results.
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Deep learning model for protein multi-label subcellular localization and function prediction based on multi-task collaborative training.

Brief Bioinform

September 2024

School of Information Science and Engineering, Shandong Normal University, No. 1 University Road, Jinan 250358, China.

The functional study of proteins is a critical task in modern biology, playing a pivotal role in understanding the mechanisms of pathogenesis, developing new drugs, and discovering novel drug targets. However, existing computational models for subcellular localization face significant challenges, such as reliance on known Gene Ontology (GO) annotation databases or overlooking the relationship between GO annotations and subcellular localization. To address these issues, we propose DeepMTC, an end-to-end deep learning-based multi-task collaborative training model.

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Background: Great apes are a global conservation concern, with anthropogenic pressures threatening their survival. Genetic analysis can be used to assess the effects of reduced population sizes and the effectiveness of conservation measures. In humans, autosomal short tandem repeats (aSTRs) are widely used in population genetics and for forensic individual identification and kinship testing.

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Unary Au Nanocrystal with Prestored Electrons and Intrinsic Low Hole-Injected Potential for Low-Triggering Potential Electrochemiluminescence.

Anal Chem

November 2024

School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), University Road # 3501, Jinan 250100, China.

Screening a novel electrochemiluminescence (ECL) system and lowering the ECL triggering potential are essential to ECL evolution. Herein, the near-infrared (NIR) ECL system with low-triggering potential ECL was constructed with weakly reductive -butylamine borane as coreactant and mercaptosuccinic acid/citrate (MSA/Cit)-capped Au (MSA/Cit@AuNCs) as luminophores. Toxic-element-free and dual-ligand MSA/Cit@AuNCs were prepared via ligand exchange and utilized as a model for developing unary metal NCs-based luminophores with more enhanced ECL performance than monoligand Au nanocrystals (AuNCs), which exhibited a two hole-injected process at around 0.

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The electrochemical reduction reaction of nitrate (NORR) is an attractive route to produce ammonia at ambient conditions, but the conversion from nitrate to ammonia, which requires nine protons, has to compete with both the two-proton process of nitrite formation and the hydrogen evolution reaction. Extensive research efforts have thus been made in recent studies to develop electrocatalysts for the NORR facilitating the production of ammonia. Rather than designing another better electrocatalyst, herein, we synthesize an electrochemically inactive, porous, and chemically robust zirconium-based metal-organic framework (MOF) with enriched intraframework sulfonate groups, SO-MOF-808, as a coating deposited on top of the catalytically active copper-based electrode.

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Ether-Free Alkaline Polyelectrolytes for Water Electrolyzers: Recent Advances and Perspectives.

Angew Chem Int Ed Engl

January 2025

Department of Energy Engineering, College of Engineering, Hanyang University, Seoul, 04763, Republic of Korea.

Anion exchange membrane (AEM) water electrolyzers (AEMWEs) have attracted great interest for their potential as sustainable, environmentally friendly, low-cost sources of renewable energy. Alkaline polyelectrolytes play a crucial role in AEMWEs, determining their performance and longevity. Because heteroatom-containing polymers have been shown to have poor durability in alkaline conditions, this review focuses on ether-free alkaline polyelectrolytes, which are more chemically stable.

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A pyritized Ordovician leanchoiliid arthropod.

Curr Biol

December 2024

Yunnan Key Laboratory for Palaeobiology, Institute of Palaeontology, Yunnan University, 650500 Kunming, China; MEC International Joint Laboratory for Palaeobiology and Palaeoenvironment, Yunnan University, 2 North Cuihu Road, Kunming 650091, China. Electronic address:

The "short-great-appendage" arthropods (Megacheira), such as Leanchoilia, have featured heavily in discussions of arthropod evolution, particularly related to the head and its appendages. Megacheirans are subject to competing interpretations, either as a clade or a grade, in the stem group of Euarthropoda or, alternatively, Chelicerata. They are most diverse in Cambrian Burgess-Shale-type deposits, where the family Leanchoiliidae is represented by six genera, characterized by the presence of three distal flagella on the great appendage with a presumed sensory function.

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Background: This article aims to examine patient safety in general practice during COVID-19.

Methods: In total, 5489 GP practices from 37 European countries and Israel filled in the online self-reported PRICOV-19 survey between November 2020 and December 2021. The outcome measures include 30 patient safety indicators on structure, process, and outcome.

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The global population is increasing at an alarming pace, leading to a rapid surge in industrialization and concomitant environmental degradation. In light of the present circumstances, it is crucial to find sustainable solutions to mitigate pollution and ensure a safe and clean environment for the present and future society. One promising solution is photocatalysis, which utilizes solar energy to address environmental issues while providing a renewable and sustainable energy source.

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Emerging evidence has indicated the linkage of traffic noise with cardiovascular diseases, However, there's a lack of extensive studies exploring the linkage of traffic noise with cardio-metabolic risk factors such as obesity. Additionally, the role of diet in the associations remains unknown. The aim is to prospectively examine the linkage of road traffic noise with obesity, especially by focusing on evaluating the impact of meat.

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The development of lithium-sulfur batteries (LSBs) marks a crucial milestone in advancing energy storage solutions essential for sustainable energy transitions. With high theoretical specific capacity, cost-effectiveness, and reduced ecological footprint, LSBs promise to enhance electric vehicle ranges, extend portable electronics' operational times, and stabilize grids integrated with renewable energy. However, challenges like complex processing, electrode instability, and poor cycling stability hinder their commercialization.

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