Men's views on factors contributing to their poor health-seeking behaviour in Limpopo Province, South Africa.

Background: The reasons for men not to seek healthcare seem similar across the world. They avoid going for regular medical check-ups, and preventive care and often disregard symptoms or delay seeking medical attention when sick, in pain, or even when their lives are in danger.

Methods: This study sought to explore the views of men on factors contributing to poor health-seeking behavior among men in Mopani, Vhembe, and Capricorn district municipalities in Limpopo Province.

Cross-Field Road Markings Detection Based on Inverse Perspective Mapping.

With the rapid development of the autonomous vehicles industry, there has been a dramatic proliferation of research concerned with related works, where road markings detection is an important issue. When there is no public open data in a field, we must collect road markings data and label them by ourselves manually, which is huge labor work and takes lots of time. Moreover, object detection often encounters the problem of small object detection.

Lab-on-the-Needles: A Microneedle Patch-Based Mobile Unit for Highly Sensitive and Detection of Protein Biomarkers.

Detection of biomarkers associated with physiological conditions provides critical insights into healthcare and disease management. However, challenges in sampling and analysis complicate the detection and quantification of protein biomarkers within the epidermal layer of the skin and in viscous liquid biopsy samples. Here, we present the "Lab-on-the-Needles" concept, utilizing a microneedle patch-based sensing box (MNP-based SenBox) for mobile healthcare applications.

Mitigation of high-fat diet-induced sarcopenia by fruit extracts via autophagic flux and mitochondrial quality control.

Unlabelled: Sarcopenic obesity, encompassing both muscle wasting and obesity, is relevant across individuals. (TS) has been shown to regulate glucose and lipid metabolisms. However, the efficacy and mechanisms of TS fruit (TSF) in sarcopenic obesity are unclear.

Exploring the Fluorination and Hydroxylation of Pore-space-partitioned Metal‒Organic Frameworks for C2H2/CH4 Separation.

We report three novel pore-space-partitioned metal‒organic frameworks (MOFs) functionalized with fluorine and hydroxyl groups using 2,3,5,6-tetrafluorobenzene-1,4-dicarboxylic acid (F4-BDC) and a new ligand 3,6-difluoro-2,5-dihydroxybenzene-1,4-dicarboxylic acid (F2(OH)2-BDC) as organic building blocks, with 1,3,5-tris(4-pyridyl)-2,4,6-triazine (TPT) as pore partition agent. With the polar fluorine and hydroxyl groups and the open metal sites being blocked by TPT, moderate molecule-framework interactions can be engineered. These three isoreticular microporous frameworks Mn-TPT-BDC-F4 (NCKU-21), Mn-TPT-BDC-F2(OH)2 (NCKU-22), and Mg-TPT-BDC-F2(OH)2 (NCKU-23) (NCKU = National Cheng Kung University) exhibit distinct single-component gas adsorption behaviors.

Exploring foreign language anxiety and resting-state EEG alpha asymmetry.

Anxiety experienced when interacting in a foreign language hinders communication through detrimental behavioral, cognitive, and somatic effects. Despite its impact, there is limited research on how neural asymmetry relates to foreign language anxiety (FLA). While researchers have investigated FLA through brain imaging, there remains an absence of studies examining its correlation with frontal alpha asymmetry.

Supramolecular Assembly, Solvent-Induced, and Mechanochromic Luminescence of Au(I) Quinoline-8-thiolates.

AuCl(PMe) and AuCl(PEt) were used to react with quinoline-8-thiolate (8-QNS) to give three Au(I) complexes, i.e., [8-QNS(AuPMe)]ClO (), [(8-QNS)Ag(AuPMe)]ClO (), and [8-QNS(AuPEt)]ClO (), which have been structurally determined by X-ray diffraction to show various intra- and intermolecular metal···metal contacts (i.

TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota.

Obesity and constipation can alter the intestinal microbiota composition, affecting intestinal barrier integrity, immune function, and metabolic processes. Numerous studies have suggested that and could increase short-chain fatty acid (SCFA) production, thus improving the intestinal microbiota composition, mitigating obesity, and protecting the gastrointestinal tract. Therefore, in this study, we aimed to investigate the impact of TWK10 (TWK10) on gut dysbiosis, obesity, and constipation induced by a high-fat diet and loperamide.

Patient experiences with a smartphone application dedicated to postoperative recovery after elective arthroplasty.

Introduction: In the rapidly evolving landscape of digital health technologies, the widespread use of smartphones has paved the way for innovative applications designed to enhance healthcare experiences. This introduction underscores the global prevalence of smartphone users and their potential in healthcare, particularly exemplified by therapeutic apps such as the 'Post Op' smartphone application. Focused on postoperative support, this app prioritises user-friendly design, data recording, and adherence to national standards.

Doxorubicin synergizes bortezomib-induced multiple myeloma cell death by inhibiting aggresome formation and augmenting endoplasmic reticulum/Golgi stress and apoptosis.

Background: Bortezomib is a standard treatment for multiple myeloma (MM), working by the accumulation of toxic misfolded proteins in cancer cells. However, a significant clinical challenge arises from the development of resistance to bortezomib in MM treatment. Aggresome, a subcellular structure enclosed within Vimentin, forms in response to proteasome inhibitors and sequesters misfolded proteins that are transported by histone deacetylase 6 (HDAC6) and Dynein for degradation via autophagy, thereby reducing bortezomib's cytotoxic effects.

Systematic Meta-Analysis of Computer-Aided Detection of Breast Cancer Using Hyperspectral Imaging.

The most commonly occurring cancer in the world is breast cancer with more than 500,000 cases across the world. The detection mechanism for breast cancer is endoscopist-dependent and necessitates a skilled pathologist. However, in recent years many computer-aided diagnoses (CADs) have been used to diagnose and classify breast cancer using traditional RGB images that analyze the images only in three-color channels.

Three new methodologies for calculating the effective sample size when performing population adjustment.

Background: The concept of the population is of fundamental importance in epidemiology and statistics. In some instances, it is not possible to sample directly from the population of interest. Weighting is an established statistical approach for making inferences when the sample is not representative of this population.

Leveraging Health Policy Solutions to Address Obesity in Rural America.

Rural America faces an alarming obesity crisis, with residents experiencing significantly higher rates of obesity due to socioeconomic disparities, limited access to healthcare, and structural challenges such as food deserts and insufficient healthcare infrastructure. This perspective addresses these pressing issues by proposing targeted, evidence-based interventions to reduce obesity in rural communities. Our recommendations include (1) increasing the number of multidisciplinary healthcare professionals in rural areas through initiatives such as the Rural Medical Scholars Program, the Rural Community Loan Repayment Program, and the Conrad 30 Waiver Program; (2) expanding coverage for essential obesity services via H.

Development and environmental performance of a pilot-scale membrane capacitive deionization system for wastewater reclamation: Long-term operation and life cycle analysis.

Wastewater reclamation is regarded as a primary solution for efficient water resource management because of its environmental friendliness and energy efficiency. Membrane capacitive deionization (MCDI) has shown great promise as a practical technology for wastewater reclamation, but challenges remain for the large-scale deployment of this technology due to gaps in understanding its technical and environmental performance. This study presents a pilot-scale MCDI-based wastewater treatment and reclamation system that includes sand filtration (SF), ultrafiltration (UF), MCDI, and ultraviolet (UV) units.

RiboSeq.Org: an integrated suite of resources for ribosome profiling data analysis and visualization.

Ribosome profiling (Ribo-Seq) has revolutionised our understanding of translation, but the increasing complexity and volume of Ribo-Seq data present challenges for its reuse. Here, we formally introduce RiboSeq.Org, an integrated suite of resources designed to facilitate Ribo-Seq data analysis and visualisation within a web browser.

Evaluation of the alkyl chain length and photocatalytic antibacterial performance of cation g-C3N4.

Several cation graphite carbon nitrides (g-C3N4-(CH2)n-ImI+) were synthesized by chemically attaching imidazolium appended alkane chains with different lengths ( = 2, 4, 8, 12 and 16) to g-C3N4. The introduction of a cation segment potentially improved the interaction between the carbon material and Gram negative (MDR-. ) and Gram positive () bacteria as characterized by potential measurement.

dbPTM 2025 update: comprehensive integration of PTMs and proteomic data for advanced insights into cancer research.

Post-translational modifications (PTMs) are essential for modulating protein function and influencing stability, activity and signaling processes. The dbPTM 2025 update significantly expands the database to include over 2.79 million PTM sites, of which 2.