3 results match your criteria: "University Park NG7 2RD Nottingham UK.[Affiliation]"
-Hydroxyethyl acrylamide as a functional eROP initiator for the preparation of nanoparticles under "greener" reaction conditions.
Polym Chem
November 2022
School of Chemistry, University of Nottingham, University Park NG7 2RD Nottingham UK
Article Synopsis
- Hydroxyethyl acrylamide acted as a functional initiator for enzymatic ring-opening polymerization of ε-caprolactone and δ-valerolactone, showing no self-reaction under specific conditions, unlike similar compounds which caused unwanted reactions.
- Despite not fully reacting during the polymerization, computational studies revealed that initiated polymer chains preferred binding to the enzyme, leading to faster polymer growth but incomplete consumption of the initiator.
- The resulting amphiphilic copolymers formed nanoparticles with low cytotoxicity, and the synthesis utilized green solvents from renewable resources to enhance sustainability.
Biocatalytic access to betazole using a one-pot multienzymatic system in continuous flow.
Green Chem
May 2021
School of Chemistry, University of Nottingham, University Park NG7 2RD Nottingham UK.
As an alternative to classical synthetic approaches for the production of betazole drug, a one-pot biocatalytic system for this pharmaceutical molecule from its alcohol precursor has been developed. An ω-transaminase, an alcohol dehydrogenase and a water-forming NADH oxidase for cofactor recycling have been combined to catalyse this reaction, yielding 75% molar conversion in batch reactions with soluble enzymes. This multienzyme system was then co-immobilised through a newly established protocol for sequential functionalization of a methacrylate-based porous carrier to enable tailored immobilisation chemistries for each enzyme.
View Article and Find Full Text PDFThe association of physiological cortisol and IVF treatment outcomes: a systematic review.
Reprod Med Biol
October 2014
Division of Primary Care University of Nottingham 13th Floor Tower Building, University Park NG7 2RD Nottingham UK.
Purpose: A systematic review was conducted to (1) collate and synthesise the available evidence for the role of cortisol in relation to IVF treatment outcomes; (2) to establish the strength of an association between cortisol and IVF; and (3) to assess the overall quality of the studies and guide future research in this area.
Methods: Seven electronic databases, including the reference lists of published papers, were searched. Inclusion criteria qualified any prospective/observational cohort study that reported original data.