Health anxiety and somatosensory amplification in adolescents with unexplained chest pain: A comparative study.

Background And Objectives: Chest pain of unknown origin in adolescents might be related to biopsychosocial factors. The aim of this study is to identify the relationship between somatic amplification of bodily sensations and health anxiety in adolescents with unexplained chest pain.

Method: The study analysed 111 adolescents with unexplained chest pain at a paediatric cardiology outpatient clinic from June to September 2018, along with a control group of 78 cases.

Exploring the interplay of selenoproteins and mir-675 in breast cancer: a focus on radiotherapy effects.

Objectives: The present study aims to investigate the changes in the expression levels of miR-675 and some selenoproteins (Sel K, Sel W, and Sel P) in patients with breast cancer, before and after radiotherapy.

Subjects And Methods: This study included 35 breast cancer patients who applied to the Department of Radiation Oncology for radiotherapy and 25 healthy female controls. miR-675 expressions were analyzed by using quantitative reverse-transcription polymerase chain reaction (qRT-PCR).

Navigating the risks: Stakeholder views on risk-based cervical cancer screening.

Background: The development of risk-based cancer screening programs requires a paradigm shift in existing practices and healthcare policies. Therefore, it is crucial to not only assess the effectiveness of new technologies and risk prediction models but also to analyze the acceptability of such programs among healthcare stakeholders. This study aims to assess the acceptability of risk-based cervical cancer screening (RB CCS) in Estonia from the perspectives of relevant stakeholders.

All-trans retinoic acid enhances anti-proliferative effect of dual PI3K and mTOR inhibitor NVP-BEZ235 in triple negative breast cancer.

Breast cancer remains the most diagnosed cancer in females and one of its most challenging subtypes is Triple Negative Breast Cancer (TNBC). Treatment of TNBC presents challenges due to limited targeted therapies, inefficacy of chemotherapy, and severe side effects. Therefore, combination therapies are preferred to reduce toxicity and drug resistance.

Built Environment and Cardiovascular Diseases - Insights from a Global Review.

Purpose Of Review: This narrative review aims to synthesize global literature on the relationship between cardiovascular diseases (CVD) and components of built environment (green spaces, walkability, food environment, accessibility and availability of recreational and healthcare facilities, and effects of air and noise pollution).

Recent Findings: Increased green space and neighborhood walkability are associated with lower CVD mortality and morbidity; however, benefits have shown differential effects by socioeconomic status (SES). Air pollution is a leading environmental risk factor contributing to CVDs, and it disproportionately impacts low SES populations and women.

Dementia prevalence and risk factors in people with and without HIV in Malawi: A medical record review.

Background: Sub-Saharan Africa (SSA) is experiencing a rapid increase in its aging population, including people living with human immunodeficiency virus (HIV) (PLHIV). The purpose of this study was to determine the prevalence of dementia among PLHIV and people without HIV (POHIV) in Malawi.

Methods: We conducted a retrospective medical record review of 400 consecutive patients from a single tertiary health center (200 PLHIV from an HIV clinic and 200 POHIV from an outpatient clinic) in Lilongwe, Malawi.

The long-term effects of interface irrigation on visual outcomes and corneal aberrations in Small Incision Lenticule Extraction (SMILE).

Purpose: To assess the long-term effects on visual outcomes and corneal aberrations of irrigating the interface during the small-incision lenticule extraction (SMILE) surgery for managing myopia and myopic astigmatism.

Methods: In 47 patients who underwent bilateral SMILE surgery for myopia and myopic astigmatism, one eye was irrigated with 1.0 ml of balanced salt solution via cannula (Group 1) and the other eye was not irrigated (Group 2).

Long-Term Quality of Life Trend after Subthalamic Stimulation for Parkinson's Disease: An Updated Systematic Review and Meta-Analysis.

Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a well-established treatment for Parkinson's Disease (PD). However, the long-term trajectory of Quality of Life (QoL) following STN-DBS remains underexplored.

Objectives: We aimed to conduct a systematic review and meta-analysis to assess QoL trends up to five years after STN-DBS.

Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta-Analyses.

Background: Numerous studies support the association of exercise training, physical activity (PA) and sedentary behaviour (SB) with both mortality and morbidity outcomes. The results across studies have been inconsistent, and no umbrella reviews have yet been conducted on this topic.

Methods: We conducted an umbrella review of meta-analyses of observational studies by screening articles in PubMed/MEDLINE, EMBASE and Web of Science databases from inception to 30 April 2024.

FDA-Approved Zuranolone: First Oral Treatment for Postpartum Depression, Ushering in a New Era of Hope; A Narrative Review.

Background And Aims: Postpartum depression (PPD) is a significant concern globally, emerging from various factors including hormonal changes, genetic influences, and environmental stressors. Conventional treatments such as psychotherapy and antidepressants have been the standard approach, but the recent U.S.

Linking Pathogenesis to Fall Risk in Multiple Sclerosis.

Multiple Sclerosis is a chronic neurological disorder characterized by progressive disability, with falls being a significant consequence of its physical and cognitive impairments. This review explores the major contributors to fall risk in individuals with multiple sclerosis and explores the broader implications of these factors, such as the fear of falling. The primary factors associated with fall risk include gait abnormalities, cognitive dysfunction, and fatigue.

Intention to leave and missed nursing care: A scoping review.

Introduction: The nursing profession is fundamental to the functioning of healthcare systems but is often characterised by high turnover rates, considerable job dissatisfaction, and a significant intention to leave. A closely related phenomenon is "missed nursing care," defined as essential nursing tasks that are omitted (partially or completely), delayed, or not performed. The relationship between missed nursing care and the intention to leave the profession represents a critical issue in modern healthcare.

Trends of Mortality due to Traumatic Brain Injury in the USA: A Comprehensive Analysis of CDC WONDER Data from 1999 to 2020.

Traumatic brain injury (TBI) poses a significant public health challenge in the United States, with diverse causes and outcomes. Understanding the trends in TBI-related mortality is crucial for effective prevention and intervention strategies. This comprehensive analysis utilized data from the (CDC WONDER) database, covering the period from 1999 to 2020.

Cross-Cultural Validation of the Binge Eating Disorder Screener-7 (BEDS-7) Across 42 Countries.

Objective: This study aimed to evaluate the reliability and validity of the Binge Eating Disorder Screener-7 (BEDS-7) across 42 countries and 26 languages, assessing its reliability and validity as a screening tool for binge-eating disorder (BED) in diverse cultural contexts. Specifically, it sought to enhance early recognition of BED symptoms in primary care settings globally, contributing to a standardized framework for assessing BED.

Method: The International Sex Survey, a cross-sectional online study, was conducted in 42 countries and 26 languages.

Transarterial Chemoembolization for Patients With Hepatocellular Carcinoma Using Miriplatin Without the Need for Hydration.

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with a rising incidence. The most common therapeutic choice for HCC is transarterial chemoembolization (TACE). While the standard protocol of TACE adopts cisplatin, the application of cisplatin needs hydration before and after the procedure to alleviate adverse effects on kidney function.

EXPRESS: Outcomes of Beta Blocker Therapy in Methamphetamine Users with Cardiovascular Conditions.

Methamphetamine use is associated with a range of cardiovascular conditions including hypertension and heart failure. Beta-blocker use is commonly avoided when treating patients intoxicated with methamphetamines due to a fear of inducing unopposed alpha stimulation and worsening hypertension. We performed a retrospective review of medical records in a county hospital in California with a high prevalence of methamphetamine users.

Evaluation of ovarian functions in girls treated for hematological malignancy.

Acute lymphoblastic leukemia (ALL) and other hematological malignancies are the most common cancers in children, with chemotherapy and/or radiotherapy as the primary treatment options. These treatments, however, may have long-term effects on ovarian function and fertility in female survivors. This study aims to evaluate ovarian function and reserve in female survivors of childhood hematological malignancies by assessing hormonal markers and ovarian follicle count.

Global mental health commentary: using innovation to create a workforce to deliver and implement culturally adapted CBT in Pakistan.

Most low- and middle-income countries (LMICs) have poor or non-existent mental healthcare. Many of LMIC countries allocate less than 1% of their health budgets to addressing mental illness, making large-scale public health interventions not a practical option, at least for the foreseeable future. Psychiatric services are limited to large urban centres, and mental health literacy is low.

Mismatch Between Preoperative MRI Findings and Postoperative Histological Results in the Treatment of Tenosynovial Giant Cell Tumor.

Background/aim: Tenosynovial giant cell tumor (TGCT) is a rare disease of young adults with a high number of cases going unreported. Despite an international consensus meeting of experts in June 2022, the majority of such patients repeatedly pose problems, even for experienced clinicians. This study deals with the question of how often postoperative histopathological findings are consistent with preoperative magnetic resonance imaging (MRI) findings.

Understanding the role of nutritional status on the outcomes of nonvariceal upper gastrointestinal bleeding: Findings from a retrospective cohort analysis.

Background & Aims: Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a common cause of hospitalization worldwide. Malnutrition, on the other hand, varies in prevalence and closely correlates with age and comorbidities. Though malnutrition is linked to poor outcomes generally, its impact on NVUGIB patients remains unexplored.

Predicting Escalation of Care for Childhood Pneumonia Using Machine Learning: Retrospective Analysis and Model Development.

Background: Pneumonia is a leading cause of mortality in children aged <5 years. While machine learning (ML) has been applied to pneumonia diagnostics, few studies have focused on predicting the need for escalation of care in pediatric cases. This study aims to develop an ML-based clinical decision support tool for predicting the need for escalation of care in community-acquired pneumonia cases.

Preclinical in vitro and in vivo evidence for CD74-targeting as effective treatment strategy for cutaneous T cell lymphomas.

Background: Prognosis and quality of life of advanced cutaneous T cell lymphoma (CTCL) patients, in particular those with Sézary syndrome (SS) and advanced-stage mycosis fungoides (MF), are poor. Monoclonal antibodies or antibody-drug conjugates (ADCs) have been implemented into CTCL therapy algorithms, but the spectrum of antibody-targetable cell-surface antigens on T cell non-Hodgkin lymphomas (T-NHL) is limited.

Objectives: To evaluate expression of the MHC-II chaperone CD74 across common subtypes of CTCL by various methods, and to explore the efficacy of CD74-targeting of CTCL cells by anti-CD74 antibody-drug conjugate (ADC) in vitro and in vivo.

Trends in hypertensive heart disease-related mortality among older adults in the USA: a retrospective analysis from CDC WONDER between 1999 and 2020.

Background: While hypertensive heart disease (HHD) has been widely studied, this study uniquely examines the impact of the COVID-19 pandemic on HHD mortality trends, which has not been thoroughly explored in the current literature. The pandemic's effects on healthcare access, economic instability, and social isolation present new challenges and opportunities for understanding HHD mortality among the elderly.

Results: Age-adjusted mortality rates (AAMRs) increased overall between 1999 and 2020, from 36.