Buprenorphine-naloxone versus buprenorphine for opioid use disorder during pregnancy: A systematic review and meta-analysis.

Background: The standard of care for treating opioid use disorder (OUD) during pregnancy includes either buprenorphine or methadone. Although buprenorphine-naloxone presents an alternative due to the reduced risk of misuse , evidence regarding its impact on pregnancy and infant health remains limited. This systematic review and meta-analysis aims to compare buprenorphine-naloxone vs buprenorphine alone for OUD during pregnancy, assessing gestational and neonatal outcomes.

Modified expression of JAK-STAT pathway genes in an in vivo rheumatoid arthritis model: A preclinical study to explore genetic insights.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by inflammatory synovial tissue, joint deterioration, and effects on systems other than the joints. The biological process underlying the progression of the disease remains unknown, however cell-mediated immunity plays an important part in the onset of RA. The current study investigated the involvement of the JAK-STAT pathway genes (JAK-1, IL-6, and SOCS-2) in the pathogenesis of RA (Rheumatoid arthritis).

Seasonally recurring patterns of dominant Crenothrix spp. in a European alluvial drinking water well: Significance and potential indicator role.

Iron and manganese (Fe/Mn) often lead to aesthetic quality issues in water supply. Strong and problematic black-brown particle formation was persistently observed in an alluvial drinking water well, even though oxygen enrichment probes, intended for in situ i.e.

Effect of the voxel size on the accuracy of endodontic length measurements using cone-beam computed tomography: A systematic review conducted according to the PRISMA guidelines and Cochrane Handbook for Systematic Reviews of Interventions.

Background: The accurate determination of the working length (WL) is imperative for endodontic success.

Objectives: Our objective was to systematically analyze the available evidence on the impact of voxel size variation on the estimation of WL using cone-beam computed tomography (CBCT).

Material And Methods: An electronic search of the PubMed, Scopus, Embase, and Web of Science databases was conducted according to specific inclusion and exclusion criteria in March 2022.

Autophagy and Programmed Cell Death Modalities Interplay in HIV Pathogenesis.

Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according to the Joint United Nations Program on HIV/AIDS (UNAIDS) at the end of 2021 with 1.5 million new infections.

Primate Behavior and the Importance of Comparative Studies in Biological Anthropology.

Biological anthropology seeks to understand humans from an evolutionary perspective. Namely, what makes humans different from other animals, and how did we get this way? Many relevant traits are physical, but many others are behavioral. For example, when and why did our species develop complex cognition, enduring bonds, and intense cooperation? Given the importance of behavior, biological anthropologists have a long history of turning to our primate relatives to generate hypotheses about the evolutionary processes shaping humans.

Relationship and Determinants of Breastfeeding Self-Efficacy Among Postpartum Mothers and Fathers in Malawi: A Cross-Sectional Study.

Background: Breastfeeding self-efficacy among both mothers and fathers is critical in enhancing exclusive breastfeeding rates. However, the interrelationship between maternal and paternal breastfeeding self-efficacy and their determinants remains unknown.

Research Aims: We aimed to (a) investigate the relationship between breastfeeding self-efficacy scores postpartum for mothers and fathers; (b) explore factors associated with breastfeeding self-efficacy in this group; and (c) examine determinants of combined self-efficacy scores among breastfeeding parents in Malawi.

Endoscopic Dacryocystorhinostomy - Comparative Outcomes of Powered vs. Non - Powered Instrument Techniques in a Tertiary Care Hospital.

This study compares the outcomes and complications associated with Powered and Non - Powered instrument techniques in patients undergoing Endoscopic Dacryocystorhinostomy (Endo DCR). An Observational, longitudinal study was carried out on 146 cases of Chronic Dacryocystitis who were divided into two equal groups. One group underwent Endo DCR by powered instruments (Powered group - PG) and the other group by non-powered technique (Non Powered group - NPG).

Primary cardiac lymphoma presenting with wide QRS tachycardia: a case report.

Background: Lymphomas, which originate from the haematopoietic system, are seldom found in the heart due to the absence of a lymphoid system. Primary cardiac lymphoma is quite rare. Cardiac lymphomas can present with dyspnoea, heart failure, pericardial effusion, and arrhythmia.

Reconstruction with Modified Bilobe Flap Method in Facial Cancer: Case Report.

Basal cell carcinoma and squamous cell carcinoma are the most common cancers in the skin of the head and neck region where sun exposure is the most intense. The main principle of treatment is to remove the mass with clean surgical margins. In large masses, appropriate reconstruction of the large defect should be provided.

Evaluating the potential of abbreviated MRI protocols for liver metastasis detection: a study in colorectal cancer patients.

Purpose: To evaluate the diagnostic accuracy of different abbreviated magnetic resonance imaging (AMRI) protocols consisting of dynamic enhanced + T2-weighted imaging (T2W) and diffusion-weighted imaging (DWI) + T2W for the detection and characterization of liver metastases in a patient group with known colorectal cancer.

Material And Methods: A total of 197 hepatic lesions were retrospectively analyzed across 3 different MRI sets: AMRI-1 (dynamic enhanced + T2W), AMRI-2 (DWI + T2W), and a standard MRI protocol. The patient cohort included 100 individuals (63 males, 37 females) with a mean age of 62.

Dissemination strategies of clinical practice guidelines-mixed methods evidence synthesis protocol.

Clinical practice guidelines (CPGs) are shared through various dissemination strategies using a range of dissemination products and channels. However, users may have different needs for accessing and understanding them. Patients and carers from low- and middle-income countries might face challenges in accessing CPGs such as inadequate systems for printed book distribution and insufficient and substandard photocopies.

Risk factors for oral mucosal pressure injury associated with endotracheal tubes in intensive care unit patients: A single-centre longitudinal study with brief follow-up.

Background: In intensive care units (ICUs), endotracheal tubes (ETTs) cause injury to the oral mucosa through friction and pressure. The incidence and risk factors of oral mucosal pressure injuries (PIs) have gained increasing attention in recent years.

Aim: The study aimed to identify risk factors for oral mucosal PIs associated with ETTs.

Intensive care nurses' knowledge regarding medical device-related pressure injuries and factors affecting these: A descriptive and cross-sectional study.

Aim: Nurses play a fundamental role in preventing, treating, and reducing the incidence of medical device-related pressure injuries (MDRPIs). Therefore, assessing their level of knowledge on this subject is of utmost importance. The aim of this study is to determine intensive care nurses' levels of knowledge regarding medical device-related pressure injuries and factors affecting these.

Multicentric low-grade glioma: A systematic review of a rare neuro-oncological disease.

Introduction: Multicentric and multifocal gliomas are rare and mainly described in high-grade gliomas, however, they have rarely been reported with LGG in about 2-10 % of all cases. This study aims to identify the reported multicentric low-grade gliomas (mLGGs) in literature and review their pathologies, management, and outcomes.

Methods: A systematic search using a pre-defined search strategy was conducted across three databases (PubMed, Cochrane Library, and Scopus).

Prevalence and incidence of neuromyelitis optica spectrum disorder in Türkiye: A nationwide epidemiologic study.

Background: Epidemiological studies of neuromyelitis optica spectrum disorder (NMOSD) show variability due to differences in methodologies, diagnostic criteria, and geographic factors.

Objective: This study aimed to determine NMOSD's epidemiological profile in Türkiye using official health records covering over 95 % of the population.

Methods: Data were collected using ICD-10 codes (G36.

Demographic analysis of patients requiring ophthalmology consultation in the emergency department: A retrospective study at a tertiary care center.

This study aims to determine the necessary preventive measures from the perspective of primary care by examining the demographic characteristics and initial diagnoses of patients who were evaluated by an ophthalmologist following an emergency consultation request. Individuals over the age of 18 who had complete data and were referred for ophthalmic consultation from the emergency department within in 2022 were included in the study. The study retrospectively reviewed the patients' age, gender, diagnoses, status of ophthalmic consultation, whether a forensic report was prepared, and the outcomes of follow-up, hospitalization, or discharge.

Effect of rational emotive behavioral education on electoral violence behaviors.

Background: Research indicates that young people in Nigeria mistakenly think that participating in politics is a "do-or-die" situation. This tendency has resulted in varying political beliefs, attitudes, and behavior patterns that may be irrational. This has occasionally led to a rise in the rate of social disengagement, thuggery, and electoral violence among young people.

Comparing the portrayal of #autism and #neurodiversity on TikTok: creators, content, and representation.

Background: Social media is a significant source of information on health-related topics and neurodevelopmental disorders such as autism spectrum disorder (ASD). The public perception of ASD, as reflected on social media, can raise awareness but also increase stigma. This study examined ASD portrayal on TikTok, focusing on neurodiversity, content themes, creator identities, and the depiction of autistic individuals.

Expanding horizons: the feasibility and challenges of tubular retraction in endoscopic transorbital skull base approaches.

Purpose: Endoscopic transorbital skull base approaches are always challenging and require good anatomical knowledge.The aim of this study was to describe the anatomical pathways of endoscopic transorbital approaches and to determine the limitations of these procedures. To evaluate the feasibility of the tubular retractor and the difference with manual retractor.

The enigma of familial Mediterranean fever: phenotypic characterization of patients harboring variants of uncertain significance.

Objective: To assess the phenotypic characteristics of the patients carrying variants of uncertain significance (VUS) in the Mediterranean fever (MEFV) gene.

Methods: The study included patients carrying only VUS in the MEFV gene. Patients were excluded if they did not meet the pediatric criteria for familial Mediterranean fever (FMF).

Typmpanometric Findings Pre and Post Adenoidectomy Amongst Children with Obstructive Adenoid Enlargement.

Obstructive Adenoid enlargement is a common childhood disorder. Adenoid enlargement plays a significant role in the pathogenesis of otitis media with effusion (OME). Otitis media with effusion is the commonest cause of reversible hearing loss in children.