Insights into structural and binding studies of pollen allergen Bet v 1 using computational approaches.

Unlabelled: Bet v 1, the European White Birch tree pollen allergen is responsible for a number of allergic responses in humans such as rhinitis, asthma and oral allergy syndrome. The allergen belongs to pathogenesis-related (PR) class 10 protein superfamily and exists in several naturally occurring isoforms. Limited structural information on Bet v 1 isoallergens and variants prompted us to carry out their in silico structural characterization.

Biochar for ameliorating soil fertility and microbial diversity: From production to action of the black gold.

This article evaluated different production strategies, characteristics, and applications of biochar for ameliorating soil fertility and microbial diversity. The biochar production techniques are evolving, indicating that newer methods (including hydrothermal and retort carbonization) operate with minimum temperatures, yet resulting in high yields with significant improvements in different properties, including heating value, oxygen functionality, and carbon content, compared to the traditional methods. It has been found that the temperature, feedstock type, and moisture content play critical roles in the fabrication process.

Overexpression of the general transcription factor OsTFIIB5 alters rice development and seed quality.

Overexpression of general transcription factor OsTFIIB5 in rice affects seedling growth, plant height, flowering time, panicle architecture, and seed protein/starch levels and involves modulation of expression of associated genes. TFIIB, a key general transcription factor (GTF), plays a critical role in pre-initiation complex (PIC) formation and facilitates RNA polymerase II-mediated transcription. In humans and yeast, TFIIB is encoded by a single gene; however, in plants it is encoded by a multigene family whose products may perform specialized transcriptional functions.

Exploring the correlations between social support, resilience, well-being, and mental health variables among youth in border areas of Jammu and Kashmir.

Background: The border areas of Jammu and Kashmir have long been affected by conflict, potentially impacting the mental health of youth. Understanding the relationships between social health factors and mental health outcomes in these regions is crucial for developing effective interventions.

Aim: This study aims to investigate the correlations between social health factors (social support, resilience, and well-being) and mental health outcomes (stress, anxiety, and depression) among youth living in the border areas of Jammu and Kashmir.

Prevalence and predictors of positive childhood experiences and their relationship with adverse childhood experiences among young adults in Delhi-NCR, India.

Background: Although positive childhood experiences (PCEs) have been reported to be crucial for healthy development and better mental and physical health outcomes, their epidemiology and relationship with adverse childhood experiences (ACE) exposure in low and middle-income countries, including India remain underexplored.

Aims: The present study aimed to ascertain the prevalence and predictors of PCE exposure and understand the relationship between PCE and ACE exposure among young adults in Delhi-NCR, India.

Methods: The present cross-sectional study involved a total of 1,573 young adults (18-25 years) of both sexes (69.

Identification and validation of a metabolic-related gene risk model predicting the prognosis of lung, colon, and breast cancers.

Metabolic reprogramming, vital for cancer cells to adapt to the altered microenvironment, remains a topic requiring further investigation for different tumor types. Our study aims to elucidate shared metabolic reprogramming across breast (BRC), colorectal (CRC), and lung (LUC) cancers. Leveraging gene expression data from the Gene Expression Omnibus and various bioinformatics tools like MSigDB, WebGestalt, String, and Cytoscape, we identified key/hub metabolism-related genes (MRGs) and their interactions.

Transcending Time and Space in the Search for Synthesis: A Commentary on Paranjpe's Understanding Yoga Psychology: Indigenous Knowledge with Global Relevance.

This volume makes a notable contribution with a deep and extensive analysis to achieve the movement from Yoga Philosophy to Yoga Psychology for the promotion of integration with Modern Psychology, a task hitherto unrealized despite the burgeoning attention to Yoga. This commentary is constrained by my own limited knowledge of traditional Indian philosophy in making a thorough examination of Paranjpe's contribution beyond attention to selected concepts and sporadic illustrations from the original volume. Yoga practice is, Paranjpe informs us, just the tip of an immense consolidation of knowledge, deep intellectual thought and theoretical consideration about the embodied sense of self, health and well-being.

Ecosystem productivity and carbon dynamics in Keibul Lamjao National Park, Manipur, India: a gray relational analysis perspective.

An in-depth understanding of carbon dynamics and ecosystem productivity is essential for conservation and management of different ecosystems. Ecosystem dynamics and carbon budget are assessed by estimating net ecosystem production (NEP) across different global ecosystems. An ecological productivity assessment of forest and floating meadow ecosystems in Keibul Lamjao National Park (KLNP), Manipur, North East India, was conducted using the multi-criteria decision-making process namely, gray relational analysis (GRA).

Insights into the photocatalytic removal of malachite green organic pollutant by highly efficient hard responsive BaCoDyFeO catalysts.

The widespread discharge of organic dyes into the wastewater from various industrial processes has develop a major environmental apprehension in the modern world. To tackle such environmental issues, we are synthesizing a novel catalyst of composition, BaCoDyFeO (x = y = 0.02-0.

Social Capital in Online Gaming Communities: A Systematic Review Examining the Role of Virtual Identities.

The growth of online video-game players has seen a parallel growth in online gaming communities. Membership in these communities has been well known to play a vital role in shaping social connections and fostering social capital. This systematic review explored the role of interacting virtual identities in shaping the relationship between membership in gaming communities and social capital as an outcome.

Nanoscale Prussian Blue and Its Analogues: Design and Applications in Infection Control, Wound Healing and Beyond.

Prussian blue nanoparticles (PBNPs) have gained significant attraction in the field of nanomedicine due to their excellent biocompatibility, potential for nanoscale production, exceptional photothermal conversion ability, and multi-enzyme mimicking capabilities. PBNPs have made considerable advancements in their application to biomedical fields. This review embarks with a comprehensive understanding of the physicochemical properties and chemical profiling of PB-based nanoparticles, discussing systematic approaches to tune their dimensions, shapes, and sizes, as well as their biomedical properties.

Nanotherapeutic and Nano-Bio Interface for Regeneration and Healing.

Wound and injury healing processes are intricate and multifaceted, involving a sequence of events from coagulation to scar tissue formation. Effective wound management is crucial for achieving favorable clinical outcomes. Understanding the cellular and molecular mechanisms underlying wound healing, inflammation, and regeneration is essential for developing innovative therapeutics.

Role of Aspartate 42 and Histidine 79 in the aiPLA2 activity and oligomeric status of Prdx6 at low pH.

Peroxiredoxin 6 (Prdx6), a unique non-seleno peroxidase, is a bifunctional protein with GSH peroxidase at pH 7.4 and calcium independent phospholipase A (aiPLA) activities at pH 4.0.

Enantioselective Analysis and Separation of Two β-Blockers via Derivatization Approach.

Enantiomeric analysis of chiral drugs is very significant, as their enantiomers display different pharmacological or toxicological behavior towards living systems. Among these drugs, β-blockers are available as racemates, where their enantiomers display different pharmacological effects. Herein, we report enantioselective separation of two β-blockers, namely, atenolol and sotalol, using a derivatization approach.

Unlocking the Potential: Phytoestrogens and Cardiovascular Health.

Phytoestrogens are plant-derived compounds resembling human estrogen and have recently gained attention due to their potential role in improving cardiovascular health. These compounds exert their effects through various mechanisms, including interactions with estrogen receptors, growth factor receptors, inflammatory mediators, thrombogenic reactions, and apoptotic pathways. This results in cardioprotective effects like modulating endothelial function, decreasing vessel tone, reducing inflammation, altering lipid profiles, and influencing arrhythmogenesis.

CAR-T Cell Therapy: Pioneering Immunotherapy Paradigms in Cancer Treatment.

The world's one of the major causes of death are cancer. Cancer is still a complex disease over the years that needs to be cured. Traditional cytotoxic approaches, although they have been implemented for years for treating neoplastic diseases, yet are limited due to the intricacy and low efficiency of cancer cells.

Lanthanide-Based Metal-Organic Frameworks Offering Hydrogen Bonding Cavities: Luminescent Characteristics and Sensing Applications.

This work presents the synthesis and characterization of three isomorphous lanthanide-based metal-organic frameworks (Ln-MOFs) (Ln=Eu (1), Tb (2), and Sm (3)) supported by a pyridine-2,6-dicarboxamide-based linker offering appended arylcarboxylate groups. Single crystal X-ray diffraction studies highlight that these Ln-MOFs present three-dimensional porous architectures offering large cavities decorated with hydrogen bonding (H-bonding) groups. These Ln-MOFs display noteworthy luminescent characteristics.

Predictive modeling of soil profiles for precision agriculture: a case study in safflower cultivation environments.

Evaluating high-throughput soil profile information is essential in safflower precision agriculture, as it facilitates efficient resource management and design of an experiment that promotes sustainable production. We collected soil from representative target environments (TE) of safflower cultivation and evaluated 14 soil physio-chemical features for constructing fine-resolution maps. The robustness, versatility, and predictive ability of two statistical learning models in correctly classifying the soil profile to clusters were tested.

Incremental learning algorithm for dynamic evolution of domain specific vocabulary with its stability and plasticity analysis.

Domain-specific vocabulary, which is crucial in fields such as Information Retrieval and Natural Language Processing, requires continuous updates to remain effective. Incremental Learning, unlike conventional methods, updates existing knowledge without retraining from scratch. This paper presents an incremental learning algorithm for updating domain-specific vocabularies.

Mechanistic Insights into the Divergent Membrane Activities of a Viroporin from Chikungunya Virus and Its Transframe Variant.

Alphaviruses, a genus of vector-borne viruses in the family, encode a small ion-channel-forming protein, 6K, and its transframe variant (TF) during infections. Although 6K/TF have vital roles in glycoprotein transport, virus assembly, and budding, there is no mechanistic explanation for these functions. We investigated the distinct biochemical functionalities of 6K and TF from the mosquito-borne alphavirus, Chikungunya Virus.

Innovative nanocomposites for pollutant capture: Adsorption of rhodamine B dye using polyaniline-coated chitosan trisodium citrate nanocomposites.

Wastewater contamination by organic dyes, especially Rhodamine B (RhB), possess a significant environmental challenge. This study explores a novel bio sorbent for the removal of RhB dye from contaminated water, using chitosan trisodium citrate-modified magnetic nanoparticles (Fe₃O₄@CSTSC@PANI) coated with polyaniline. The nanocomposite was characterized by FT-IR, XRD, HRTEM, SEM, BET surface analysis.

Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes.

Myeloid cell leukemia 1 (MCL-1) is a member of the B-cell lymphoma 2 protein family and has anti-apoptotic functions. Deregulation of MCL-1 has been reported in several cancers, including lung and breast cancer. In the present study, the association of MCL-1 expression with molecular features in colorectal cancer (CRC) has been highlighted.