Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer's disease treatment.

In recent decades, Alzheimer's disease (AD) has garnered significant attention due to its rapid global prevalence. The cholinergic hypothesis posits that the degradation of acetylcholine by acetylcholinesterase (AChE) contributes to AD development. Despite existing anti-AChE drugs, their adverse side effects necessitate new agents.

Network Pharmacology, Molecular Docking, and In Vitro Insights into the Potential of for Alzheimer's Disease.

Korth. Havil (MS) has a traditional use in relieving pain, managing hypertension, treating cough, and diarrhea, and as a morphine substitute in addiction recovery. Its potential in addressing Alzheimer's disease (AD), a neurodegenerative condition with no effective treatments, is under investigation.

Mapping trace metal footprints: Distribution, sources, and risk assessment in coastal sediments near a heavy industrial zone in Bangladesh.

This study investigated nine trace metals (Cr, Co, Cu, Cd, Ni, Mn, Fe, Zn, and Pb) concentrations of coastal sediments adjacent to a heavily industrialized area of Bangladesh using AAS. The most prevalent metals were zinc, with lesser amounts of Cd and Co. Pb, and Cd levels were higher than world standards, with a considerable enrichment of Pb at station 9.

Prodigiosin Demonstrates Promising Antiviral Activity Against Dengue Virus and Zika Virus in In-silico Study.

Dengue (DENV) and Zika virus (ZIKV), transmitted by Aedes mosquitoes, pose significant public health challenges. Effective treatments for these viruses remain elusive, highlighting the urgent need for new efficient antiviral therapies. This study explores prodigiosin, a microbial tripyrrole pigment, as an antiviral agent against both DENV and ZIKV employing advanced analytical approaches which integrate molecular docking, CASTp 3.

Schistophleps kendricki sp. nov. (Lepidoptera: Erebidae: Arctiinae) from Bangladesh with an overview of the genus.

Schistophleps Hampson, 1891 is one of the most frequently occurring genera of tiger moths, widely distributed in the Oriental and Australian regions. However, a lion's share of the species belonging to this genus are poorly known except the original descriptions. In this article, we provide a brief overview of all known species currently assigning to this genus.

A new genus and species of Peleopodidae Hodges, 1974 (Insecta: Lepidoptera) from South-East Asia.

Paraxenoacria gen. nov., a new genus belonging to the family Peleopodidae is described to accommodate a new species Paraxenoacria spinosa sp.

Quantitative assessment of Tm isotope production: experimental data analysis and model validation.

Tm is an effective radioisotope for use in theragnostic purposes. This study aims to find the best alternative routes for producing Tm for appropriate cancer therapy and diagnostics. In this study, we comprehensively analyzed production cross-sections of Tm and investigated the behavior of these reactions using six different level density models and refined optical model potential (OMP) parameters with the nuclear reaction code TALYS 1.

Effects of competition and ownership on the simultaneous relationship between bank risk and capital: Evidence from an emerging economy of Bangladesh.

This study aims to investigate the simultaneous relationship between bank risk and capital, specifically examining how competition and ownership jointly influence this relationship. We employed the two-step system generalized method of moments to address concerns regarding endogeneity and unobserved heteroscedasticity. Based on data from 44 commercial banks in Bangladesh from 2010 to 2021, our findings reveal several key insights: (I) There is a significant non-linear bidirectional relationship between bank risk and capital: capital exhibits a U-shaped effect on risk, while risk has a non-linear negative impact on capital; (II) in highly contested markets, banks hold higher levels of capital, and heightened competition reduces the risk appetite of commercial banks; while less competition has the opposite effect; (III) private and Islamic commercial banks are more risk-averse than state-owned and conventional ones, and (IV) Private and Islamic banks with strong capital positions in a competitive market can better manage risks than state-owned and conventional banks.

Lasia spinosa Stem Aqueous Extract Potentiates Antidiabetic Effects Exhibiting Antioxidant Genes Upregulation and DNA-Damage Protection.

This research elucidated the hypoglycemic effect correlated with DNA-protective and antioxidative activity of Lasia spinosa stem aqueous extract (LSSAE) using streptozotocin-induced type 2 diabetic rat models. LSSAE, characterized by phytochemical screening, gas chromatography-mass spectroscopy (GC-MS), and FTIR analyses, was investigated for its DNA-protective activity by exposing PBR322 plasmid DNA to Fenton's reagents. Long Evans rats, treated by LSSAE, were found to be improved for body weight, fasting blood glucose level, and oral glucose load.

Spatial distribution of heavy metal in sands and sediments of Parki Beach, Chattogram, Bangladesh.

To assess the sources, levels, spatial distributions and exposure to human health, the concentration of heavy metals Pb, Cu, Mn, Zn, and Fe in the sand/sediment of the Parki Beach area of Anowara, Chattogram, Bangladesh are determined using Atomic Absorption Spectroscopy (AAS) for the first time. A total of 40 surface and subsurface sand and sediment samples were collected from 20 different sampling points along the 15 km long Parki Beach area, Bangladesh. Average concentrations of Pb, Cu, Mn, Zn and Fe in surface samples are 14.

Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies.

Cyclotriazadisulfonamide (CADA) is a macrocyclic compound known for its unique mechanism in inhibiting HIV infection by downregulating the CD4 T-cell receptor, a crucial entry point for the virus. Unlike other antiretrovirals, CADA exhibits activity against a wide range of HIV strains, as all HIV variants require CD4 binding for infection. Furthermore, CADA has shown a synergistic effect with clinically approved anti-HIV drugs, offering potential for enhanced therapeutic strategies (Vermeire & Schols, [65]).

Welfare assessment of broiler chickens at live bird market of Chattogram in Bangladesh.

Objective: This study aimed to assess the welfare conditions of broiler chickens in the live bird markets (LBMs) in Bangladesh.

Materials And Methods: A total of fifty broiler outlets were studied in 10 LBMs of Chattogram, Bangladesh. A total of 10 chickens were observed to check the welfare issues during slaughter from each outlet ( = 500).

Elucidating the monoamine oxidase B inhibitory effect of kaurene diterpenoids from Xylopia aethiopica: An in silico approach.

Parkinson disease is a neurogenerative disease common in adults and results in different kinds of memory dysfuntions. This study evaluated the monoamine oxidase B (MAO-B) inhibitory potential of kaurane diterpenoids previously isolated from Xylopia aethiopica through comprehensive computational approaches. Molecular docking study and molecular dynamics simulation were used to access the binding mode and interaction of xylopic acid and MAO-B enzyme.

An In Silico Approach to Discover Efficient Natural Inhibitors to Tie Up Epstein-Barr Virus Infection.

Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. EBV is a widespread virus and causes infectious mononucleosis, which manifests with symptoms such as fever, fatigue, lymphadenopathy, splenomegaly, and hepatomegaly. Additionally, EBV is associated with different lymphocyte-associated non-malignant, premalignant, and malignant diseases.

Biocultural Conservation of Indigenous Foods and Their Potential as Alternative Food Sources in Chittagong Hill Tracts (CHTs), Bangladesh.

This study documented the lesser-known indigenous fruits and vegetables used in a montane area of high biocultural diversity in Bangladesh, the Chittagong Hill Tracts (CHTs), and analyzed the nutritional values of selected species. Over 125 species were noted, and based on their frequent uses, 10 plant species were selected for nutritional analysis. All of the analyzed fruits and vegetables contain significant amounts of nutrients.

Analysis of Heavy Metal Pollution in the Water of the Halda River: A Distinctive Breeding Habitat for Carp Fish in Bangladesh.

Background: The present study aimed to assess the heavy metal concentrations in water from different sampling sites of the Halda River, the only natural breeding ground of Indian major carps.

Objectives: We have analysed the contamination level and seasonal variations of heavy metals (viz. Fe, Cu, Zn, Cr, Cd and Pb).

Computational design and evaluation of a polyvalent vaccine for viral nervous necrosis (VNN) in fish to combat Betanodavirus infection.

Viral nervous necrosis (VNN) poses a significant threat to the aquaculture industry, causing substantial losses and economic burdens. The disease, attributed to nervous necrosis viruses within the Betanodavirus genus, is particularly pervasive in the Mediterranean region, affecting various fish species across all production stages with mortality rates reaching 100%. Developing effective preventive measures against VNN is imperative.

Validation study of the Korean version of the COVID-19 Anxiety Scale (CAS-7) and psychometric comparison of different rating scales.

We aimed to explore the validity and reliability of the Korean version of the COVID-19 Anxiety Scale (CAS-7) among the general population and compare the psychometric properties of the CAS-7 with major rating scales for viral anxiety according to the generalized anxiety disorder-7 (GAD-7) during the coronavirus disease 2019 (COVID-19) pandemic. This anonymous online survey was conducted among the general population in South Korea during November 9-15, 2021, and 400 people participated. The survey form included demographic characteristics and rating scales, including the CAS-7, Stress and Anxiety to Viral Epidemics-6 items (SAVE-6), Coronavirus Anxiety Scale (CAS), Fear of COVID-19 scale (FCV-19S), and GAD-7.

Determinants of stunting among children under 5 years in Bangladesh: a quantile regression analysis.

Background: Child undernutrition is a major public health problem in developing countries that contributes to increased incidence of morbidity and mortality. Stunting is a valid and widely acknowledged measure of chronic child malnutrition.

Methods: This study extracted data of 7778 under-5 children from the 2017-2018 Bangladesh Demographic and Health Survey and aims to explore the relationship between socio-demographic factors and the nutritional status of children under the age of 5.

Corrigendum: Designing a polyvalent vaccine targeting multiple strains of varicella zoster virus using integrated bioinformatics approaches.

[This corrects the article DOI: 10.3389/fmicb.2023.