An Overall Validation Approach Based on β-Content, γ-Confidence Tolerance Interval, and Uncertainty Profile: Application to LC-MS/MS Quantification of Carbendazim in Drinking Water.

Background: Carbendazim is a fungicide which can seep into the water supply, presenting a public health risk, and therefore the accurate trace determination of this substance is very important.

Objective: The purpose of the study is to take a top-down analytical validation approach in order to determine the amount of carbendazim in drinking water by using an SPE-LC-MS/MS technique.

Methods: Quantification of carbendazim using solid-phase extraction coupled with LC-MS/MS was used in order to ensure the accuracy of the analytical method and to control the risk of its routine application.

Olanzapine induced hyponatremia and rhabdomyolysis.

Rapid-onset hyponatremia and rhabdomyolysis are rare, but potential, complications of olanzapine treatment. Hyponatremia, secondary to atypical antipsychotic use, has been reported in many case reports and is thought to be associated with an inappropriate antidiuretic hormone secretion syndrome. We report a case of sudden-onset hyponatremia associated with a severe rhabdomyolysis resulting in a coma-necessitating intensive care unit admission.

Assessment of the Association of Chlamydia e pneumoniae Infection with Lung Cancer in a Moroccan Patients' Cohort.

Background: Chlamydia pneumoniae (C. pneumoniae) is a respiratory pathogen associated with chronic inflammatory and its detection in human lung cancer suggests its involvement in cancerogenesis. Our study aimed to evaluate the association between C.

Value of Verbal Autopsy in a Fragile Setting: Reported versus Estimated Community Deaths Associated with COVID-19, Banadir, Somalia.

Background: Accurate mortality data associated with infectious diseases such as coronavirus disease 2019 (COVID-19) are often unavailable in countries with fragile health systems such as Somalia. We compared officially reported COVID-19 deaths in Somalia with COVID-19 deaths estimated using verbal autopsy.

Methods: We interviewed relatives of deceased persons to collect information on symptoms, cause, and place of death.

Quality Control and Authentication of Argan Oils: Application of Advanced Analytical Techniques.

In addition to the nutritional and therapeutic benefits, Argan oil is praised for its unique bio-ecological and botanic interest. It has been used for centuries to treat cardiovascular issues, diabetes, and skin infections, as well as for its anti-inflammatory and antiproliferative properties. Argan oil is widely commercialized as a result of these characteristics.

Physicochemical Characterization and Antioxidant Properties of Essential Oils of (L.), (Ehrh.) and (L.) from Moroccan Middle-Atlas.

The cosmetics and food fields are based on the use of synthetic substances to protect their products against oxidation. However, synthetic antioxidants were reported to have negative effects on human health. The interest to develop natural antioxidants from plants has been growing in recent decades.

Stable smart packaging betalain-based from red prickly pear covalently linked into cellulose/alginate blend films.

Smart materials based on biomaterials have been shown growing interest by researchers. This paper investigated pH-indicator film with less leaching containing betalain molecule extracted from red prickly pear fixed in the cellulose-alginate blend as a matrix. Herein, the film was manufactured from a blend containing covalently bounded cellulose with betalain via the creation of a Fischer esterification (FE) to solve the leaching problem of dyes in contact with food.

Phytochemical profile and antioxidant capacity, α-amylase and α-glucosidase inhibitory activities of Oxalis pes-caprae extracts in alloxan-induced diabetic mice.

Diabetes and its complications are closely correlated with chronic hyperglycemia, causing severe oxidative stress and leading to glycation reaction with formation of advanced glycation end products. However, medicinal plants are still a source of inspiration for the discovery of new treatments of several diseases, including diabetes. The present study was aimed to evaluate the antioxidant and antidiabetic properties of Oxalis pes-caprae flowers extract in alloxan-induced diabetic mice.

Phytochemical Compounds, Acute Toxicity, Anti-Inflammatory and Antioxidant Activities of Murb Essential Oil.

The present study was conducted to evaluate the acute toxicity and anti-inflammatory effect in vivo, as well as the antioxidant activity, of the essential oil of . The results indicate that the tested essential oil is non-toxic, with an estimated LD50 of 2500 mg kg of mice body weight. The anti-inflammatory test revealed that, at a dose of 200 mg kg, the essential oil reduced rat paw edemas by 89.

Prevalence and predictive determinants of adherence to vaccination against COVID-19 among mothers who gave birth in the last two years in Morocco.

Background And Aim: Vaccination against COVID-19 was one of the most important resolute to stop the spread of the pandemic; however, its acceptance was controversial especially by pregnant and lactating women. This study aims to assess the prevalence of vaccination among participants as well as to explore the determinants of reluctance or adherence to vaccination among this population, and to investigate the intention towards vaccination among the unvaccinated.

Method: This is a cross-sectional study conducted among mothers (n = 458) residing in the prefecture of Skhirat-Temara in Morocco, and who have children aged between one month to 2 years, the survey was conducted on the basis of a semi-structured questionnaire.

Neoadjuvant endocrine therapy with or without palbociclib in low-risk patients: a phase III randomized double-blind SAFIA trial.

Background: The most prevalent subtype of breast cancer (BC) is luminal hormonal-positive breast cancer. The neoadjuvant chemotherapy regimens have side effects, emphasizing the need to identify new startegies.

Objective: Analyze the complete pathologic response (pCR) rate and overall response in a low-risk hormone-positive subset of patients receiving neoadjuvant hormone treatment (NAHT) with or without Palbociclib (a CDK4/CDK6 inhibitor) to boost NAHT effectiveness.

Radioiodine scan revealing a primary lung adenocarcinoma in a patient with differentiated thyroid carcinoma.

The radioiodine scan is a non-invasive imaging modality that allows for the visualization of functional thyroid tissue, as well as the detection of thyroid cancer remnants and metastases. However, it is important to note that radioiodine uptake is not exclusive to thyroid tissue and can lead to false-positive results if unexpected uptake occurs in non-thyroidal tissue. Herein, we present a case of a patient diagnosed with thyroid carcinoma, whose radioiodine scan demonstrated increased uptake in the thorax, corresponding to a lung carcinoma.

Impact of the anode tilt on photon emission spectrum and temperature rise in an x-ray tube.

In radiology, the photon fluence and the energy spectrum generated from an x-ray tube may depend on the anode tilt angle. In this contribution, a Monte Carlo investigation is performed to quantify this effect by modeling an x-ray tube based on published data Bujila R.(2020.

Knowledge, attitudes and practices related to Covid-19 among health professionals in El Jadida Province, Morocco.

Background: During the COVID-19 pandemic, concerns were raised about the lack of knowledge and awareness of health workers (HW) in hampering the implementation of COVID-19 preventive strategies in hospitals.

Objective: This cross-sectional study aims to explore the knowledge, attitudes, and practices (KAP) of the health workers related to COVID-19 in Moroccan hospitals and health facilities.

Materials And Methods: We administered an adapted questionnaire to 242 HW working in Azemmour and El Jadida hospital (two sites) and in 41 health centers in El Jadida province.

Composition and Chemical Variability of the Essential Oil from Aerial Parts of Cladanthus scariosus, an Endemic Species to the Moroccan High Atlas.

Cladanthus scariosus (Ball) Oberpr. & Vogt is endemic to Moroccan High Atlas. It is known under the vernacular names Irezghi or Irezgui.

FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.

At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned).

Clinical Significance of Somatic Mutations in RAS/RAF/MAPK Signaling Pathway in Moroccan and North African Colorectal Cancer Patients.

Background: Mutations in RAS (KRAS, NRAS) and BRAF genes are the main biomarker predicting response to anti-EGFR monoclonal antibodies in targeted therapy in colorectal cancer (CRC).

Objective: Our study aims to evaluate the frequencies of KRAS, NRAS and BRAF mutations and their possible associations with clinico-pathological features in CRC patients from Morocco.

Methods: DNA was extracted from 80 FFPE samples using the QIAamp DNA FFPE-kit.

Protective and positioning devices in maxillofacial prosthodontics and radiotherapy: Overview.

Background: Radiation therapy (RT) is a common modality of treatment in patients with head and neck cancer, and can cause several oral complications. These mainly include radiomucitis, oral pain, hyposalivation, limitation of mouth opening, and osteoradionecrosis.There are different intraoral devices aimed at reducing these complications.

Chemical Composition, Antioxidant, Anti-Diabetic, Anti-Acetylcholinesterase, Anti-Inflammatory, and Antimicrobial Properties of L. and L. Essential Oils.

The objectives of this work were to determine the phytochemical composition and antioxidant, anti-diabetic, antibacterial, anti-inflammatory, and anti-acetylcholinesterase properties of L. and L. EOs.

Evaluating the baseline survival outcomes of the "six Global Initiative for Childhood Cancer index cancers" in Africa.

Limited survival data for the six Global Initiative for Childhood Cancer (GICC) priority cancers are available in Africa. Management of pediatric malignancies in Africa is challenging due to lack of resources, setting-specific comorbidities, high rates of late presentation and treatment abandonment. Reporting of outcome data is problematic due to the lack of registries.

Phytochemical Variability, In Vitro and In Vivo Biological Investigations, and In Silico Antibacterial Mechanisms of Essential Oils Collected from Two Different Regions in Morocco.

The objective of this work is to explore the phytochemical profile of essential oils (MPEO) collected from two different Moroccan regions using gas chromatography-mass spectrophotometer (GC-MS) and to investigate their antioxidant, anti-inflammatory, antidiabetic and, antimicrobial effects using in vivo and in vitro assays. The chemical constituent of MPEO from the Azrou zone is dominated by carvone (70.25%), while MPEO from the Ouazzane zone is rich in Menthol (43.

A Preliminary Study on the Potential of FT-IR Spectroscopy and Chemometrics for Tracing the Geographical Origin of Moroccan Virgin Olive Oils.

Background: The authentication of the geographical origin of virgin olive oils (VOO) generally requires the use of sophisticated and time-consuming analytical techniques. There is a need for quick and simple analytical techniques to predict the origin of olive oils.

Objective: This study aims to examine the physico-chemical data of olive oils collected in six regions of Morocco during two consecutive years 2020 and 2021, and also to evaluate the ability of FT-IR in combination with discrimination tools to study the geographical origin of Moroccan olive oils.

Review of prostate cancer genomic studies in Africa.

Prostate cancer (PCa) is the second most commonly diagnosed in men worldwide and one of the most frequent cancers in men in Africa. The heterogeneity of this cancer fosters the need to identify potential genetic risk factors/biomarkers. Omics variations may significantly contribute to early diagnosis and personalized treatment.

Cancer patients and COVID-19 vaccination, from safety to protocol adherence: A real-life setting report.

Background: The SARS-CoV-2 pandemic has slowed down cancer prevention and treatment strategies; consequently, cancer patients are prioritized to get the COVID-19 vaccines. Being constantly threatened by a new outbreak, the dive within the immunogenicity response is of great value; nonetheless, evaluating the side effects of these vaccines on fragile patients will assure their adherence to the vaccination protocol.

Objectives: This study sets out to investigate the adverse events reported about the vaccine according to its doses and types, and to compare the prevalence and severity of toxicities across two subgroups of cancer patients, those who received the injection during active therapy cycles, and those who have not started the therapy yet at vaccination time, moreover, this paper examines the will and commitment of this population to the vaccination schemes.

Phytochemistry, Biological and Pharmacological Activities of the (L.) Lag: A Systematic Review.

(L.) (Asteraceae) is an important annual medicinal herb and is widespread in Morocco and Algeria. Most of its parts are used in traditional medicine and the roots are the most important parts used.