565 results match your criteria: "University Mohammed V-[Affiliation]"

Bacterial urinary tract infections (UTIs) are common, ranging from benign cystitis to complicated pyelonephritis, which can lead to severe complications such as pyonephrosis and sepsis. Pyonephrosis, characterized by the presence of pus in the renal cavities, often requires urgent urological intervention. We report a unique case of pyonephrosis with a psoas abscess caused by and in a 64-year-old diabetic female patient.

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Pituitary stalk interruption syndrome (PSIS) is a congenital anatomical defect that leads to pituitary insufficiency, The symptoms are diverse, often leading to diagnostic delays or even misdiagnosis. MRI plays a crucial role in establishing an accurate diagnosis by revealing a characteristic radiological triad: a thin or absent pituitary stalk, an ectopic or missing posterior pituitary gland, and anterior pituitary hypoplasia. We herein describe 2 cases: 1 involving a 9-year-old boy and the other an 11-year-old girl, both diagnosed with PSIS.

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This study aimed to investigate the chemical composition and bioactivities of essential oils (EOs) from five Moroccan thyme species: subsp. , , subsp. , and .

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Complications in CRS and HIPEC: From Reduction to Effective Management.

J Surg Oncol

January 2025

Peritoneal Surface Malignancy Unit, Surgical Oncology Department, National Institute of Oncology, University Mohammed V in Rabat, Rabat, Morocco.

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Introduction: The use of urine cytobacteriological examination is a common and essential practice in medicine which helps guide therapeutic management in case of urinary tract infection. The cytological examination of urine samples can be done using the manual (microscopic) or automated technique. The automated approach, which involves the use of artificial intelligence, is faster, more reliable, and more efficient for laboratories.

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Newborn Screening for Six Primary Conditions in a Clinical Setting in Morocco.

Int J Neonatal Screen

December 2024

Laboratory of Genomic, Epigenetics, Precision and Predictive Medicine, School of Medicine, Mohammed VI University of Sciences and Health, Casablanca 82403, Morocco.

Unlabelled: Newborn screening (NBS) represents an important public health measure for the early detection of specified disorders; such screening can prevent disability and death, not only from metabolic disorders but also from endocrine, hematologic, immune, and cardiac disorders. Screening for critical congenital conditions affecting newborns' health is a great challenge, especially in developing countries such as Morocco, where NBS program infrastructure is lacking. In addition, the consanguinity rate is high in Morocco.

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Background: In Morocco, latent tuberculosis infection (LTBI) is a public health concern affected by the country's location as transit area between sub-Saharan Africa with high TB burden to Europe. This study aimed to assess the influence of exposure intensity to Mycobacterium tuberculosis (Mtb), age, and Bacille Calmette-Guérin (BCG) vaccination on LTBI prevalence in Morocco.

Methods: A cross-sectional study of 131 participants, including 98 non-exposed healthy volunteers (NEHV) and 33 healthcare workers exposed to active TB (exposed healthcare workers [EHCW]), was conducted.

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Introduction And Importance: Juvenile breast hypertrophy, also known as juvenile macromastia or juvenile gigantomastia, is a rare disorder characterized by rapid, excessive breast growth in prepubertal or peripubertal girls, with no apparent cause. Juvenile breast hypertrophy is considered one of the most challenging mastopathies to manage.

Case Presentation: We present the case of a 12-year-old Moroccan girl with virginal breast hypertrophy, who was successfully treated.

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Introduction And Importance: , a member of the family within the order, is predominantly associated with urinary tract infections in hospitalized individuals, particularly those with indwelling urinary catheters. However, wound infections caused by are exceedingly rare, with an estimated incidence of around 0.1 %.

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The goal of our study was to explore the association of the polymorphisms in the JAK/STAT pathway among Moroccan COVID-19 patients, using a case-control approach. Next-generation sequencing was employed to investigate the IFNAR1, IFNAR2, JAK1, TYK2, STAT2, and IRF9 genes within the JAK/STAT pathway. We also performed an in silico study to examine the rare variants in this pathway.

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Background: Urinary tract infection, defined as the presence of bacteria or yeast in the urinary tract, is the most common community-acquired infection after respiratory infections. The cytobacteriological examination of urine (CBEU) remains the primary diagnostic test for urinary tract infections and is the most frequently conducted test in microbiology laboratories. Direct examination is a crucial step of CBEU, enabling the assessment of cytology, including leukocytes and red blood cells, as well as the identification of crystals, epithelial cells, and microorganisms when present in significant quantities.

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Innovative photocatalytic systems designed to enhance efficiency of nitrogen fixation processes, specifically focusing on sustainable ammonia (NH) production strategies via dinitrogen (N) reduction into ammonia (NH). This process is critical for sustainable agriculture and energy production. To improve photocatalyst activity, catalyst stability and reusability, reduction efficiency due to electron/hole recombination, and light-absorption efficiency has drawn extensive attention.

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Two Moroccan Families with Emery-Dreifuss Muscular Dystrophy and Report of a Novel Pathogenic Variant.

Mol Syndromol

December 2024

Research team in genomics and molecular epidemiology of genetic diseases, Genomics Center of Human Pathologies, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat, Rabat, Morocco.

Article Synopsis
  • - Emery-Dreifuss muscular dystrophy (EDMD) is a neuromuscular disorder that leads to muscle weakness and heart problems, mainly caused by mutations in specific genes, identified through next-generation sequencing (NGS).
  • - The study examined two Moroccan patients with EDMD, revealing one with a known splicing variant and another with a new frameshift variant, along with testing relatives for carrier status.
  • - The findings highlight NGS as crucial for accurately diagnosing EDMD, managing patient care, and providing genetic counseling to affected families.
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  • Inorganic halide perovskites like Cs₂InSbX₆ (X = F, Cl) are being researched for their potential in solar cells and photocatalysis due to their ability to capture light effectively.
  • The study used Density Functional Theory (DFT) to analyze how mechanical strain impacts the electronic and optical properties of these materials, finding that negative strain improves their performance, especially for Cs₂InSbCl₆, which absorbs well in the visible spectrum.
  • Results suggest Cs₂InSbCl₆, with its adjustable bandgap and enhanced optical properties under strain, could be an eco-friendly alternative to lead-based perovskites in solar energy applications.
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Plexiform neurofibroma is characterized by diffuse intraneural neoplastic overgrowth involving a long nerve segment, with tortuous expansion of its branches. It is a hallmark of Neurofibromatosis Type 1 (NF1). We report the case of a 36-year-old man with a known diagnosis of NF1, who was admitted for chronic posterior cervical pain and cervicobrachial neuralgia.

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In this article, we report the case of an 8-year-old child with multiple hereditary exostoses, revealed by the rapid and painful growth of bone deformities in the right leg. After performing a CT scan, multiple exostoses were observed in the pelvic region and both lower limbs. Notably, the exostosis in the right fibula was larger and exhibited a thickened cartilaginous cap.

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Robotization in microbiology.

Ann Biol Clin (Paris)

November 2024

Laboratory of Microbiology. Faculty of Medicine and Pharmacy (University Mohammed the First), Oujda, Morocco, Laboratory of Microbiology, Mohammed VI University Hospital, Oujda, Morocco, Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed the First, 60000 Oujda, Morocco.

Article Synopsis
  • Williams and Trotman aimed to automate bacteriology processes since 1960, but faced challenges like high costs and traditional methods that delayed progress.
  • Automation started with blood culture incubators and eventually improved efficiency in various bacteriology areas, such as cytology and antibiotic testing, leading to faster lab results and enhanced quality.
  • The integration of artificial intelligence in bacteriological analyses signifies a further transformation, resulting in fully automated labs with less human involvement, ultimately impacting healthcare quality.
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Prospective Validation of a One-Step RT-qPCR-based Test for Quantifying HER2 Gene Expression in Breast Cancer.

Asian Pac J Cancer Prev

November 2024

Diagnostic kit and medical devices center, Moroccan Foundation for Advanced Science Innovation and Research (MASCIR), University Mohammed VI Polytechnic, Lot 660, Hay Moulay Rachid Ben Guerir, 43150, Morocco.

Objective: To Validate a one-step RT-qPCR as a reliable diagnostic tool in HER-2 positive breast cancer. Further, establishing this tool as a standard procedure to quantify HER-2 expression in Breast cancer patient.

Methods: Here we report a prospective validation study that shows the concordance of one-step RT-qPCR in assessing the HER2 levels in formalin-fixed paraffin-embedded (FFPE) tissue samples with the current paradigm of diagnosis such as Immunohistochemistry (IHC) and Fluorescence-in-situ Hybridization (FISH).

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Grass pea ( L.) is a nutritious legume crop well-adapted to fragile agro-ecosystems that can survive under challenging climatic conditions. The cultivation of grass pea faces stigma primarily due to the presence of --Oxalyl--, -diaminopropionic acid (-ODAP), which is associated with a risk of inducing neurolathyrism upon prolonged consumption of its grains as a staple diet.

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Article Synopsis
  • A diagnosis of hemorrhagic ovarian cystadenofibroma was established after surgery, which involved detorsion and removal of the affected ovary.
  • The case emphasizes the importance of quick surgical action in emergencies like ovarian torsion and the critical role of advanced imaging techniques, like MRI, in accurately diagnosing complex conditions.
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Arteriovenous malformation associated with trophoblastic retention post-cesarean section: A case report and review.

Int J Surg Case Rep

December 2024

Department of Gynecology-Obstetrics, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy of Rabat, University Mohammed V, Rabat, Morocco.

Article Synopsis
  • * A case involved a 32-year-old woman diagnosed with a uterine AVM after experiencing bleeding post-miscarriage, confirmed through ultrasound and MRI, leading to successful treatment involving embolization and tissue removal.
  • * This report highlights the importance of using non-invasive imaging techniques like ultrasound and MRI for early diagnosis of uterine AVMs, allowing for conservative treatment options that help preserve fertility in women of childbearing age.
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Chemical Composition and Analgesic and Antidiabetic Activity of Chenopodium ambrosioides L.

Cell Biochem Funct

December 2024

Laboratory of Analytical Chemistry and Food Science, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Article Synopsis
  • This study investigates the active compounds in Chenopodium ambrosioides for their analgesic and antidiabetic properties, motivated by the plant's therapeutic effects.
  • The research utilized gas chromatography-mass spectrometry to analyze various aqueous extracts and fractions, finding several significant chemical families and compounds associated with these properties.
  • In the assays, the ethyl acetate fraction (EAF) displayed the highest α-amylase inhibition, while the infused aqueous macerate (EAM) was the most effective against α-glucosidase, outperforming the standard antidiabetic drug acarbose.
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Article Synopsis
  • H. pylori infection remains highly prevalent in Africa despite a decline, causing significant health issues in 10%-20% of those infected.
  • An online survey conducted across 21 African countries revealed that dyspepsia was the main reason for testing, with stool antigen tests and gastric biopsies being common diagnostic methods.
  • The study highlights the variability in healthcare practices and calls for the creation of localized, evidence-based management guidelines for H. pylori in Africa, facilitated by the African Helicobacter and Microbiota study group.
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Background: This study aimed to evaluate the immunogenicity of a two-dose Sinopharm BBIB-CorV (Vero cells) vaccine against SARS-CoV-2, at 28 days, 6 months, and 1-year postvaccination. And assess the capacity of two-dose vaccine recipients to neutralize SARS-CoV-2 strains B.1 (Wuhan/D614G), B.

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