Gaze and viewing angle influence visual stabilization of upright posture.

Focusing gaze on a target helps stabilize upright posture. We investigated how this visual stabilization can be affected by observing a target presented under different gaze and viewing angles. In a series of 10-second trials, participants (N = 20, 29.

Item-level discordance in parent and adolescent reports of parenting behavior and its implications for adolescents' mental health and relationships with their parents.

The phenomenon of discordance between parents' and children's ratings of the child's mental health symptoms or of parenting behavior until recently has been treated as a problem of reliability. More recent work has sought to identify factors that may influence discordance, yet much remains to be learned about why informants' ratings of developmental phenomena are discordant and the meaning of such discordance. This study examined the extent to which discordance can be treated as a measure of the difference between two equally valid perceptions, and as such an indicator of the quality of the parent-adolescent relationship.

Meta-analysis of randomized trials of drug-eluting stents versus bare metal stents in patients with diabetes mellitus.

Diabetes mellitus is a major risk factor for restenosis in patients undergoing percutaneous coronary intervention. Randomized controlled trials comparing drug-eluting stents (DESs) with bare metal stents (BMSs) showed a marked decrease in in-stent restenosis and target lesion revascularization with DESs in the total patient population enrolled in the studies, including patients with diabetes. However, it remains unclear whether the antirestenotic benefit of DESs is preserved in the high-risk diabetic subgroup.

Demand for poison control center services "surged" during the 2003 blackout.

Background: Beginning 8/14/03, for 24 hours, the largest geographic power failure in U.S. history occurred.

Multiple mechanisms of growth hormone-regulated gene transcription.

Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein complexes involving transcription factors, co-regulators and additional nuclear proteins; these serve as targets for regulation by hormones and signaling pathways. Evidence that GH regulates transcription at multiple levels is exemplified by analysis of the proto-oncogene c-fos.

Clinical inquiries. What is the best management for patients who have a TIA while on aspirin therapy?

Alternative antiplatelet therapy for stroke prevention is indicated for patients who experience transient ischemic attacks (TIAs) while on aspirin therapy (strength of recommendation [SOR]: A, based on 1 meta-analysis and 1 randomized controlled trial). The combination of aspirin and extended-release dipyridamole reduces the risk of stroke following a TIA (SOR: A). Thieno-pyridines (eg, clopidogrel and ticlopidine) are an alternative for patients at high risk for a cardioembolic event.

The use of trained observers as an evaluation tool for a multi-hospital bioterrorism exercise.

Introduction: Evidence suggests that regular disaster exercises have beneficial effects on subsequent mock and actual disaster responses. The purpose of this report is to describe a multiple hospital, bioterrorism exercise, evaluated by independent observers who used an evaluation template.

Methods: The overall tabletop exercise design included participation from 23 Joint Commission Accreditation of Healthcare Organizations hospitals, four health departments, and a representative from one federal agency.

Rheological characterization of topical carbomer gels neutralized to different pH.

Purpose: The primary objective of this study is to perform detailed and extensive rheological characterization of rheology of carbomer (Carbopol) microgels formulated using a solvent system typically used in topical gel formulations. Solvents like glycerin and propylene glycol can alter rheology and drug delivery characteristics of topical gels owing to their different viscosities and due to the change in solvent-polymer and solvent-solvent interactions.

Methods: Aqueous gels with different pH were prepared by dissolving cross-linked Carbopol polymers in a co-solvent system comprising water, propylene glycol, and glycerol and subsequently neutralizing the carboxylic groups of the polymers with triethanolamine (TEA).

Diagnostic studies in the assessment of pediatric sleep-disordered breathing: techniques and indications.

In summary, SDB is a common condition in children that can have serious complications if left undiagnosed and untreated. OSA is the most commonly recognized form of SDB in children. The history and physical have limitations in their capacity to determine which children have SDB.

Vascular endothelial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic protein.

Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity.