2,182 results match your criteria: "University Medical-Centre Hamburg Eppendorf[Affiliation]"

Undiagnosed AIDS in a 13-year-old boy in rural Gabon.

IDCases

October 2024

Center for Tropical Medicine, Bernhard-Nocht Institute for Tropical Medicine & I. Dept. of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Article Synopsis
  • Prevalence of HIV
  • : Approximately 38.4 million people live with HIV globally, with a significant number (1.7 million) being children under 14, primarily in sub-Saharan Africa, where mother-to-child transmission is common and diagnoses are often delayed.
  • Case Report
  • : A 13-year-old boy from rural Gabon experienced repeated fever and fatigue for years, leading to multiple undiagnosed hospital visits. Ultimately, he was diagnosed with late-onset AIDS after serologic testing revealed HIV-1 infection.
  • Importance of Early Detection
  • : The case underlines the critical need for HIV testing in children and adolescents, especially in malaria-prone areas, as early diagnosis can significantly improve
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Article Synopsis
  • - The study investigates the role of soluble CD27 (sCD27) and its potential as a biomarker to predict patient responses to immune checkpoint inhibitors (ICIs) in cancer therapy, as many patients do not achieve lasting results with current treatments.
  • - Researchers assessed serum and plasma levels of sCD27 across three patient cohorts (totaling 187 individuals) receiving ICI therapy, utilizing immunoassays and investigating both circulating and extracellular vesicle-bound forms of CD27.
  • - Results showed that lower levels of sCD27 in patients treated with ICIs were associated with longer progression-free survival and overall survival, suggesting that sCD27 could serve as a valuable predictive biomarker for the effectiveness of ICI treatments.
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Background: Medical leadership plays an increasing role already in early career stages. Undergraduate medical students in the transition to postgraduate education feel not well prepared for their leadership roles. While leadership curricula have been developed, instruments for students' self-assessment of leadership competences as part of their professional development are still missing.

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Background: Endovascular procedures are the preferred method for treating peripheral arterial disease. However, limited imaging options during these procedures, such as X-rays and contrast media, expose patients and healthcare professionals to potentially harmful radiation. This study introduces a robotic ultrasound system (RUSS) for navigating endovascular procedures in order to reduce radiation and provide additional information.

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Identification of late-stage tau accumulation using plasma phospho-tau217.

EBioMedicine

November 2024

Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Montreal, Quebec, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, QC H3A 1A1, Canada. Electronic address:

Article Synopsis
  • This study focuses on identifying individuals with advanced Alzheimer's disease (specifically Braak V or VI) using plasma biomarkers in those who are already confirmed to have amyloid-β (Aβ).
  • Researchers evaluated 595 participants from two studies, employing tests like amyloid-PET and tau-PET while measuring various plasma tau levels.
  • Findings suggest that elevated levels of plasma pTau-217 are strongly associated with Braak V positivity, indicating it could be a useful biomarker for patient stratification in treatment and clinical studies.
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Article Synopsis
  • * A detailed analysis revealed a three-factor structure of gambling attitudes: "attitudes while gambling," "sensation-seeking/excitement," and "gambling fallacies," with "gambling fallacies" being the only factor significantly associated with worse gambling disorder severity.
  • * The findings suggest that treatment should focus specifically on addressing and mitigating "gambling fallacies," as a more nuanced understanding of gambling beliefs could improve care and outcomes for individuals with gambling disorders.
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Introduction: Smoking remains a significant global public health issue, leading to numerous preventable deaths and disabilities annually. Telephone counselling is a recommended intervention for smoking cessation, offering accessible support to a wide range of people who smoke. This study aimed to evaluate the long-term effectiveness of the German quitline for smoking cessation.

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is a Gram-negative, facultative anaerobe proteobacterium. Its natural habitat is water and soil in tropical and subtropical regions. Human infections are characterized by rapid dissemination that can lead to high fatality rates.

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Article Synopsis
  • Biparametric MRI (bpMRI) may serve as a valid alternative to multiparametric MRI (mpMRI) for diagnosing clinically significant prostate cancer (csPCa), as assessed in a large international observer study.
  • The study involved 400 mpMRI examinations from four different European centers, where readers evaluated both bpMRI and mpMRI for their ability to accurately diagnose csPCa, finding them to be similarly effective.
  • Key findings indicated that bpMRI and mpMRI had comparable diagnostic accuracy (AUROC values) and sensitivity, with bpMRI showing a noninferior performance, though both methods had similar specificity when distinguishing csPCa.
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Imaging Initial Ca2+ Microdomains in Primary T Cells.

J Vis Exp

October 2024

The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf;

Article Synopsis
  • * When T cell receptors are activated, NAADP is quickly produced, interacting with specific proteins that trigger the release of calcium from internal stores, leading to a rise in intracellular calcium levels.
  • * A new high-resolution imaging technique using two calcium indicators, along with a Python-based detection system, allows for the precise capture and analysis of these dynamic Ca microdomains in T cells and other cell types.
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Article Synopsis
  • This study investigates structural brain aging by analyzing both cross-sectional and longitudinal data from over 37,000 healthy individuals in the UK Biobank, identifying two distinct patterns of brain aging.
  • Participants showing signs of accelerated brain aging also experienced faster biological aging, cognitive decline, and higher genetic risks for neuropsychiatric disorders.
  • The research supports the 'last in, first out' hypothesis linking brain aging to brain development, and includes genomic analysis to uncover genetic factors influencing both accelerated brain aging and delayed development.
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Background: Transgender and gender diverse (TGD) people in remote areas face challenges accessing health-care services, including mental health care and gender-affirming medical treatment, which can be associated with psychological distress. In this study, we aimed to evaluate the effectiveness of a 4-month TGD-informed e-health intervention to improve psychological distress among TGD people from remote areas in northern Germany.

Methods: In a randomised controlled trial done at a single centre in Germany, adults (aged ≥18 years) who met criteria for gender incongruence or gender dysphoria and who lived at least 50 km outside of Hamburg in one of the northern German federal states were recruited and randomly assigned (1:1) to iTransHealth intervention or a wait list control group.

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Despite the increasing inclusion of communication skills in accreditation standards and an increase in time dedicated to teaching these skills, communication is often regarded as a separate skill and is therefore, not consistently represented in overall systems of assessment in Health Professions Education (HPE). The ascendence of competency-based medical education, programmatic assessment, artificial intelligence, and widespread use of telehealth, alongside changing patient expectations warrant an update in thinking about the assessment of communication skills in health professions education. This consensus statement draws on existing literature, expert pinion, and emerging challenges to situate the assessment of communication skills in the contemporary health professions education context.

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Therapy adherence after interdisciplinary tumour board discussion is associated with improved outcome in soft tissue sarcoma: A Charité Comprehensive Cancer Centre analysis.

Int J Cancer

February 2025

Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Centralising soft tissue sarcoma (STS) treatment in expert centres and implementing comprehensive therapy concepts through interdisciplinary tumour boards (ITB) has led to significant treatment progress. However, our knowledge on the implementation of the ITB recommendations and its impact on patient outcome is limited. In this retrospective analysis, we examined a cohort of 222 adult patients (pts) with primary STS who were presented to the ITB of the Charité Comprehensive Cancer Centre between 2015 and 2020.

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Background: Attention-deficit/hyperactivity disorder (ADHD) is associated with increased costs for the family, the health care system and the society. Previous cost-of-illness studies in Germany usually focused on prevalent ADHD. This study addressed the research gap on health care resource utilisation and costs of children and adolescents with incident ADHD diagnosis using nationwide claims data from the statutory health insurance DAK-Gesundheit.

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Background: The study examines the psychometric properties of the ADHD section of the semi-structured diagnostic interview ILF-EXTERNAL, which was conducted online via video chat.

Methods: As part of the INTEGRATE-ADHD research project, 202 children and adolescents (age = 12.87 years, = 3.

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ADHD in children and adolescents: Guideline-based online assessment in the consortium project INTEGRATE-ADHD.

J Health Monit

September 2024

University Hospital Würzburg, Centre of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Germany.

Background: The consortium project INTEGRATE-ADHD compared administrative data on the presence of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with the results of a parent survey and a comprehensive clinical assessment based on the S3 guideline of the Association of the Scientific Medical Societies in Germany (AWMF). Due to the COVID-19 pandemic, the clinical assessment was carried out online.

Methods: The article describes how a guideline-based clinical assessment of ADHD can be implemented in an online setting.

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Background: This article examines discrepancies in the frequency of diagnoses of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents in Germany using information on health care utilisation from both administrative and parent-reported survey data linked at person level.

Methods: 5,461 parents of 0- to 17-year-olds insured with DAK-Gesundheit in 2020 and being registered with a confirmed administrative ADHD diagnosis (ICD-10 F90.0-9) in at least one quarter in 2020 (M1Q criterion) were surveyed online on their child's ADHD diagnosis, utilisation of specialist care and therapeutic service providers.

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Article Synopsis
  • The INTEGRATE-ADHD project linked ADHD diagnosis data from parents and administration for the first time in Germany, analyzing discrepancies based on sociodemographic factors.
  • A survey of 5,461 children revealed that 71.6% of parents confirmed their child's ADHD diagnosis, with lower reporting rates among girls, younger children, those with migration backgrounds, and children from nuclear families.
  • About one-third of parents did not report their child's ADHD diagnosis, indicating variations in reporting influenced by sociodemographic characteristics, which should be considered in future data interpretations.
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Background: The health-related quality of life (HRQoL) of individuals living with Attention-deficit/hyperactivity disorder (ADHD) is known to be impaired. Identifying factors that influence HRQoL can provide important information for the development of prevention and intervention programmes for affected children and adolescents. The aim of the present study was to investigate health care-related and psychosocial risk and protective factors for HRQoL in children and adolescents with an administrative ADHD diagnosis.

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Article Synopsis
  • mRNA vaccines have proven effective against COVID-19 and hold promise for other uses, as they change the activity of certain genes in the body post-vaccination.
  • This study analyzed blood transcriptomes before and after mRNA vaccination to identify gene networks that are either upregulated or downregulated based on the response to the vaccine.
  • The research found that specific gene networks related to immune response and processes like viral defense can be targeted for improving future vaccine designs, potentially enhancing their effectiveness.
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Safety, immunogenicity, and optimal dosing of a modified vaccinia Ankara-based vaccine against MERS-CoV in healthy adults: a phase 1b, double-blind, randomised placebo-controlled clinical trial.

Lancet Infect Dis

October 2024

Institute for Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Hamburg-Lübeck-Borstel-Riems partner site, German Centre for Infection Research, Hamburg, Germany; First Department of Medicine, Division of Infectious Diseases, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Article Synopsis
  • MERS-CoV is a serious respiratory virus with a high mortality rate and currently no licensed vaccines, prompting research into a candidate vaccine called MVA-MERS-S, which uses a modified vaccinia virus.
  • A phase 1b clinical trial was conducted with healthy volunteers (ages 18-55) across Germany and the Netherlands to evaluate the safety and immunogenicity of MVA-MERS-S, testing various dosing schedules and comparing it to a placebo group.
  • The trial involved 244 screened participants, with 140 randomly assigned to different dosing regimens, and the outcomes focused on both the safety of the vaccine and the resulting immune response measured through antibody levels and seroconversion rates.
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Gut Hormones: Possible Mediators of Addictive Disorders?

Eur Addict Res

October 2024

Department of Psychiatry, University of Cambridge, Cambridge, UK.

Background: Alcohol and drug dependence are major health and economic burdens to society. One of the major challenges to reducing this burden will be to develop more effective and better tolerated medications that target alternative mechanisms in the brain. While the dopamine system has been well characterized for mediating the reward value of drugs, there is evidence that the endocrine system also conveys signals to the same neural systems using gut hormones.

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