3,874 results match your criteria: "University Medical Centre Ljubljana[Affiliation]"

Article Synopsis
  • - Vaginal evisceration is a rare and serious complication that can occur after vaginal hysterectomy, requiring immediate detection and surgical intervention to avoid severe outcomes like bowel ischemia and sepsis.
  • - A case study involved an 84-year-old woman who, two years post-hysterectomy, experienced acute abdominal pain and had her small bowel protruding through the vaginal vault.
  • - During surgery, the bowel was manually repositioned without the need for resection, and the condition's causes are unclear but likely involve multiple factors; various surgical methods are effective, so the chosen approach should match the patient's specific situation.
View Article and Find Full Text PDF
Article Synopsis
  • Advanced chronic lymphocytic leukemia (CLL) leads to an increase in regulatory T cells (Tregs) and higher risk of severe infections, particularly linked to heightened FOXP3 expression in these cells.
  • A study utilizing flow cytometry assessed STAT5 signaling in Treg subsets among 37 CLL patients, looking at how this related to disease progression and tumor mass.
  • Findings indicated that a specific subset of activated Tregs (aTregs) was correlated with advanced disease and severe infection rates, suggesting aTreg levels could serve as a marker for disease severity and that increased STAT5 signaling may contribute to their expansion.
View Article and Find Full Text PDF

Clinical Characteristics and Outcomes of Tympanomastoid Paragangliomas: A Report from Slovenia.

Cancers (Basel)

September 2024

Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Zaloška cesta 2, 1000 Ljubljana, Slovenia.

Article Synopsis
  • A study at the University Medical Centre, Ljubljana analyzed the management of temporal bone paragangliomas from 2011 to 2023, reviewing 23 cases, with 19 patients undergoing surgery and 4 receiving radiotherapy due to tumor progression.
  • Results indicated that surgical removal for classes A and B tumors is generally effective, while radiotherapy serves as a reliable alternative for managing tumors that continue to grow after surgery is declined.
View Article and Find Full Text PDF
Article Synopsis
  • The study assesses the effectiveness of white blood cell count (WBC) in predicting serious bacterial infections (SBI) in children compared to C reactive protein (CRP) and absolute neutrophil count (ANC).
  • After analyzing data from over 17,000 febrile children across multiple European emergency departments, WBC showed poor predictive value with a sensitivity of 56% and specificity of 74% for WBC >15.
  • The findings suggest that CRP is a better marker for identifying SBI in children, and WBC should only be used for specific cases rather than as a routine diagnostic tool.
View Article and Find Full Text PDF
Article Synopsis
  • Metabolic disorders are prevalent among psoriasis patients, increasing their risk for cardiovascular issues, but the effect of biologic therapies on these metabolic parameters is unclear.
  • A study involving 80 young psoriasis patients treated with various biologics and 20 healthy controls revealed no significant metabolic differences between the treated patients and the controls.
  • The findings suggest that young psoriasis patients successfully treated with biologics experience no significant residual metabolic burden, similar to those treated with topical therapy or methotrexate, which is important for their overall treatment approach.
View Article and Find Full Text PDF

Introduction: Thoracolumbar spine injuries can result from various traumatic events such as falls, motor vehicle accidents, and sports injuries. While surgical intervention is often indicated for complex fractures and in case of neurological deficits, non-operative treatment remains a viable option for certain types of injuries.

Aims: This manuscript aims to provide a comprehensive overview of the specific indications and treatment options of non-operative thoracolumbar spine injuries.

View Article and Find Full Text PDF

Thoracolumbar fractures are common injuries that usually result from high energy trauma. They can lead to significant morbidity due to neurologic impair - or mortality - if not managed according to strict and rapid intervention rules in terms of decompression of the spinal cord, and rigid fixation of the fracture. This manuscript reviews emergency treatment protocols, imaging modalities, and classification systems used for thoracolumbar fractures.

View Article and Find Full Text PDF

Transglabellar Butterfly Incision for Anterior Cranial Vault Access: Case Report.

Curr Oncol

September 2024

Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia.

(1) Background: The transglabellar approach, a type of transfacial technique, typically involves glabellar resection and opening the frontal sinus via a bicoronal incision, providing access to the anterior cranial vault. To prevent complications, the frontal sinus is typically obliterated. However, the success of transnasal endoscopic techniques has prompted a re-evaluation of these traditional methods.

View Article and Find Full Text PDF

The aim of our study was to compare the total 25(OH)D fraction, the bioavailable vitamin fraction, and the free vitamin D fraction in spring and fall in a group of healthy individuals. In our study, we collected blood samples from healthy participants at the end of both summer and winter, and measured serum levels of albumin, DBP, and 25(OH)D. Utilizing these data, we calculated the percentage of free and bioavailable vitamin D.

View Article and Find Full Text PDF

Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor.

Parkinsonism Relat Disord

November 2024

Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

Introduction: Primidone and propranolol are primary treatments for essential tremor, however the exact mechanisms underlying their efficacy are not fully elucidated. Understanding how these medications alleviate tremor may guide the development of additional pharmacologic treatments. Our prospective observational study employed transcranial magnetic stimulation (TMS) to explore mechanisms of primidone and propranolol effects in essential tremor.

View Article and Find Full Text PDF

Sex dependence of postoperative pulmonary complications - A post hoc unmatched and matched analysis of LAS VEGAS.

J Clin Anesth

December 2024

Amsterdam University Medical Center, Department of Anaesthesiology, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands; Amsterdam University Medical Center, Department of Intensive Care, Meibergdreef 9, 1105AZ Amsterdam, the Netherlands.

Article Synopsis
  • The study aimed to investigate whether there are differences in postoperative pulmonary complications (PPCs) between males and females following surgery under general anesthesia, using data from the LAS VEGAS study involving 146 hospitals across 29 countries.
  • A total of 9,697 patients were analyzed in two cohorts: an unmatched cohort (55.1% female, 44.9% male) and a matched cohort (50% female and male), finding no significant differences in PPC rates between the genders in both cohorts.
  • The study concluded that, in this international patient population, the incidence of PPCs did not differ significantly between males and females, as well as noting comparable hospital stays and mortality rates.*
View Article and Find Full Text PDF
Article Synopsis
  • Congenital erythrocytosis (CE) is being recognized as a primary cause of increased red blood cell counts in patients after ruling out other conditions, prompting a study to explore the genetic factors behind idiopathic erythrocytosis.
  • Over a 5-year period, 40 patients were analyzed for factors like erythropoietin levels, hemoglobin, and potential genetic variants, with a focus on their medical history including thrombotic events and smoking status.
  • The findings showed that 20% of patients had specific variants in the gene of interest, with only one being linked to hemochromatosis, while no definitive pathogenic variants for CE were detected, indicating further investigation into genetic causes may be necessary
View Article and Find Full Text PDF

Importance: Red blood cell (RBC) transfusions are frequently administered to preterm infants born before 32 weeks of gestation in the neonatal intensive care unit (NICU). Two randomized clinical trials (Effects of Transfusion Thresholds on Neurocognitive Outcomes of Extremely Low-Birth-Weight Infants [ETTNO] and Transfusion of Prematures [TOP]) found that liberal RBC transfusion thresholds are nonsuperior to restrictive thresholds, but the extent to which these results have been integrated into clinical practice since publication in 2020 is unknown.

Objective: To describe neonatal RBC transfusion practice in Europe.

View Article and Find Full Text PDF

Management of complications in patients with an ileostomy: an umbrella review of systematic reviews for the EndOTrial Consortium.

Int J Colorectal Dis

September 2024

Department of Medicine, Division of Gastroenterology, Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

Background: Standardized clinical care processes for patients with Crohn's disease (CD) and a permanent ileostomy (PI) are lacking. The EndOTrial consortium aims to address this gap by developing pathways for care.

Methods: In this umbrella review, we searched major databases for relevant systematic reviews (SRs) or scoping reviews (ScR) published until January 5, 2024.

View Article and Find Full Text PDF

Objectives: To describe the characteristics and causes of non-aneurysmal thunderclap headache (TCH) and compare serious from benign underlying causes.

Methods: Retrospective cohort study of consecutive adult patients with TCH presenting to a tertiary care academic medical center between 2010 and 2020. Aneurysmal subarachnoid hemorrhage cases were excluded.

View Article and Find Full Text PDF

Dyslipidemia and lower extremity arterial disease.

Int Angiol

August 2024

Division of Surgery and Interventional Science, Department of Surgical Biotechnology, University College London Medical School, University College London (UCL), London, UK.

Introduction: Dyslipidemia is an established risk factor for cardiovascular diseases. We aimed to review its role in the pathogenesis of lower extremity arterial disease (LEAD), as well as the effect of lipid-lowering treatment on the progression of LEAD.

Evidence Acquisition: PubMed/MedLine, EMBASE and Scopus were searched between January 1990 and January 2024 for articles investigating the role of dyslipidemias and hyperlipidemias in the pathogenesis of LEAD.

View Article and Find Full Text PDF

Emerging treatment strategies for polycystic ovary syndrome women with obesity: Focus on glucagon-like peptide-1 receptor agonists.

J Diabetes Complications

November 2024

Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Centre Ljubljana, Slovenia; Department of Internal Medicine, Faculty of Medicine, University of Ljubljana, Slovenia. Electronic address:

View Article and Find Full Text PDF
Article Synopsis
  • Focal imaging abnormalities in parkinsonism patients indicate a secondary cause, necessitating a unique diagnostic and treatment approach.
  • Various factors such as vascular issues, brain injuries, and toxic exposures can lead to secondary parkinsonism, presenting with symptoms like rigidity and bradykinesia, often without rest tremor.
  • Neuroimaging, especially MRI, is vital for diagnosis, as recognizing imaging abnormalities in context can lead to effective treatment; many secondary forms are reversible, improving our understanding of Parkinson's disease and brain function.
View Article and Find Full Text PDF

Background: Timely and economic provision of revascularisation procedures is a major healthcare need. We aimed to examine the safety and efficacy of daycase-based lower extremity endovascular revascularisation procedures in patients with peripheral artery disease.

Methods: In this systematic review and meta-analysis, we searched MEDLINE and Embase for studies from Jan 01, 2000 through Apr 01, 2024 reporting complications of lower limb endovascular revascularisation procedures with same-day discharge.

View Article and Find Full Text PDF

Orofacial clefts are the most common congenital anomaly of the face, and they significantly affect appearance. The combined effects of demographics, psychology, neurophysiology, and cleft characteristics to explain satisfaction with appearance in young people with a cleft have not yet been comprehensively studied in an interdisciplinary manner. We found that interpersonal difficulties, age, and conscientiousness were significant explanatory factors for satisfaction with appearance (t = -3.

View Article and Find Full Text PDF

According to the European Union (EU) Directive 2005/36, the medical specialty of oral and maxillofacial surgery (OMFS) exists with two possible formats: dual degree OMFS called Dental, Oral and Maxillofacial Surgery (DOMFS) - basic medical and basic dental training and single medical degree Maxillofacial Surgery (MFS). Within the EU and across all of Europe, differences in the nature and quality of OMFS training coexist. By implementing the highest possible standards of training, patient care can be improved.

View Article and Find Full Text PDF

Various techniques have been used in attempts to reduce interfering gastrointestinal activity in myocardial perfusion imaging (MPI); however, these approaches have yielded inconsistent results. The goal of this study was to investigate the efficacy of monitored walking, a previously unexplored technique, in reducing subdiaphragmatic activity-related artifacts during pharmacologic stress Tc-tetrofosmin MPI with SPECT to improve the overall image quality. The study included patients who underwent MPI with pharmacologic stress.

View Article and Find Full Text PDF

Background: This study aimed to evaluate the safety and efficacy of emergency and prophylactic uterine artery embolization (UAE) in our clinical practice, including technical success, clinical success, and associated complications.

Patients And Methods: In this retrospective study, we analyzed 64 women who underwent emergency ( =18) and prophylactic ( = 46) UAE. Indications for emergency UAE included postpartum hemorrhage or severe hemorrhage during pregnancy termination, while prophylactic UAE was performed prior to surgical removal of retained products of conception (RPOC), delivery with abnormal placental implantation, or pregnancy termination (cervical pregnancy or fetal anomalies accompanied by abnormal placental implantation).

View Article and Find Full Text PDF

Background: To review the characteristics of all Slovenian patients with ocular adnexal lymphoma (OAL) in the period of 24 years with the aim of evaluating demographic data, lymphoma location and type, disease stage, treatment modality, local control rate and survival rate.

Patients And Methods: All patients with histologically diagnosed OAL in the main tertiary centre of Slovenia, Eye Hospital, University Medical Centre Ljubljana, who were treated at Institute of Oncology Ljubljana were included in the study. Patients' data were collected from October 1995 through April 2019.

View Article and Find Full Text PDF