3,879 results match your criteria: "University Medical Centre Ljubljana[Affiliation]"

Acute traumatic spinal cord injury (tSCI) is a complex and heterogeneous injury, where the level of injury, injury severity, duration and degree of spinal cord compression, and blood pressure management seem to influence neurologic outcome. Although data in the literature seem to be inconsistent regarding the effectiveness of surgical decompression and spinal fixation in patients with thoracic and thoracolumbar tSCI, some single-center studies suggest that early surgical decompression may lead to a superior neurologic outcome, especially in patients with incomplete tSCI, suggesting surgical decompression to be performed as soon as possible. However, high energy injuries, especially to the upper thoracic levels, may be too severe to be influenced by surgical decompression, which may represent a critical second hit for the polytraumatized patient.

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Peripheral arterial disease (PAD) represents one of the most frequent manifestations of atherosclerosis in men and women. In both sexes, PAD is related to classical risk factors of atherosclerosis, which are similarly distributed, but some additional factors determine differences between men and women. More frequent asymptomatic disease in women than in men and less frequent screening in women may result in a false underestimation of the prevalence of PAD in women.

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Introduction: Salbutamol is a moderately selective beta-2-adrenergic agonist. Various side effects can occur because of beta-1 and beta-2 receptor activation. Due to the large volume of distribution, it is not considered dialyzable.

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The aim of the present study was to investigate the impact of CCR5 Δ32 and CTLA-4 polymorphisms on the response to IFN-β treatment in our cohort of MS patients from Croatia and Slovenia. Genomic DNA was obtained from 295 MS patients (230 female; 65 male) classified as responders ( = 173) and non-responders ( = 122) based on clinical criteria for treatment efficacy. Genotyping was performed via PCR/PCR-RFLP.

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  • Patients with total hip arthroplasty (THA) may experience recurrent pain due to various issues related to the joint and surrounding tissues, such as tendons and nerves.
  • Ultrasound (US) plays a crucial role in diagnosing these conditions, allowing for quick identification of problems and evaluation of pain relief through localized anesthetic injections.
  • US guidance can also assist in procedures like fluid aspiration from the joint and injections of treatments such as corticosteroids and platelet-rich plasma for therapeutic benefits.
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Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels.

Environ Res

November 2024

Department of Environmental Sciences, Jožef Stefan Institute, 1000, Ljubljana, Slovenia. Electronic address:

Article Synopsis
  • Lead (Pb) is a harmful contaminant that can affect fetal development during pregnancy, with exposure occurring through diet and maternal bone release.
  • The study explored how different variants of the Apolipoprotein E gene (APOE) in pregnant women relate to Pb levels in both maternal and cord blood, considering the sex of the fetus and the number of previous pregnancies (parity).
  • Results showed that the maternal ε2 gene variant correlated with higher Pb levels in female fetuses, while the ε4 variant correlated with lower Pb levels, highlighting the complex roles of genetics and fetal factors in Pb exposure during pregnancy.
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The increasing global incidence of obesity and type 2 diabetes mellitus (T2D) underscores the urgency of addressing these interconnected health challenges. Obesity enhances genetic and environmental influences on T2D, being not only a primary risk factor but also exacerbating its severity. The complex mechanisms linking obesity and T2D involve adiposity-driven changes in β-cell function, adipose tissue functioning, and multi-organ insulin resistance (IR).

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Objectives: To evaluate the facial characteristics of edentulous older adults who underwent rehabilitation using complete dentures, and to compare them with dentate individuals.

Background: Edentulism rehabilitation with complete dentures aims to restore occlusion and facial aesthetics.

Materials And Methods: The study included 102 edentulous participants needing prosthodontic rehabilitation with complete dentures and 30 with a natural dentition (aged >65).

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  • Researchers wanted to understand how often young kids under two get fractures and if they’re from accidents or abuse.
  • They looked at various studies from 1946 to 2024 and found that about 5 to 9 kids out of every 1,000 get fractures each year.
  • The most common fractures happened in the arm and leg bones, while infants had fewer fractures, mostly in the collarbone.
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Preterm born (PTB) infants are at risk for injuries related to oxidative stress. We investigated the association between antioxidant and neurodevelopmental gene polymorphisms and oxidative stress parameters in PTB male young adults and their term-born counterparts at rest and during exercise. Healthy young PTB (N = 22) and full-term (N = 15) males underwent graded exercise tests in normobaric normoxic (FO = 0.

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The present study investigated the effects of a 10-week preparatory training period on biomarkers and jumping performance and associations of changes in biomarkers, load, and jumping performance from the beginning (PRE) to the end of the preparatory period (POST) in elite handball players. Seventeen elite handball players competing in the first Slovenian men's League were recruited. Training, competition and academic loads were reported weekly, while biomarkers and jumping performance were assessed at PRE and POST.

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Investigating the Protective Role of the Mitochondrial 2158 T > C Variant in Parkinson's Disease.

Mov Disord

September 2024

Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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Background: The COVID-19 pandemic raised concern amongst clinicians that disease-modifying therapies (DMT), particularly anti-CD20 monoclonal antibodies (mAb) and fingolimod, could worsen COVID-19 in people with multiple sclerosis (pwMS). This study aimed to examine DMT prescribing trends pre- and post-pandemic onset.

Methods: A multi-centre longitudinal study with 8,771 participants from MSBase was conducted.

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  • This study evaluates the clinical features and outcomes of acute cannabis toxicity versus acute synthetic cannabinoid receptor agonist toxicity in European emergency departments from 2013-2020.
  • Using data from the European Drug Emergencies Network Plus, researchers analyzed 2,657 cases of cannabis exposure and 503 cases of synthetic cannabinoid exposure to compare their effects.
  • The findings indicate that synthetic cannabinoid exposures are linked to more severe neuropsychiatric symptoms, while cannabis exposures are associated with cardiovascular issues.
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: To date, data regarding the characteristics and management of obstructive, stable coronary artery disease (CAD) encountered in patients undergoing transcatheter aortic valve implantation (TAVI) are sparse. The aim of the study was to analyze granular details, treatment, and outcomes of patients undergoing TAVI with obstructive, stable CAD from real-world practice. : REVASC-TAVI (Management of myocardial REVASCularization in patients undergoing Transcatheter Aortic Valve Implantation with coronary artery disease) is an investigator-initiated, multicenter registry, which collected data from patients undergoing TAVI with obstructive stable CAD found during the pre-TAVI work-up.

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  • * A study involving 99 SMA type I-III patients examined the perceptions of treatment benefits among different outcome groups, consisting of those with significant, non-significant, or no improvement after 15 months of treatment.
  • * The findings indicate that there is little difference in how patients and caregivers perceive the benefits of treatment among the different groups, suggesting that standard functional scales may not fully capture their real-life experiences with the treatment.
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Oral contraceptives (OCs) are usually used to treat endometriosis; however, the evidence is inconsistent about whether OC use in the past, when given to asymptomatic women, is protective against the development of future disease. We aimed to assess the relationship between the use of OCs and the likelihood of discovering endometriosis, considering the length of time under OCs during their fertile age. This was a monocentric retrospective cohort study in a tertiary-care University Hospital (Department of Human Reproduction, Division of Gynaecology and Obstetrics, University Medical Centre Ljubljana, Slovenia) carried out from January 2012 to December 2022.

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Platinum-resistant high-grade serous carcinoma (HGSC) is an incurable disease, so biomarkers that could help with timely treatment adjustments and personalized approach are extensively being sought. Tumor-derived extracellular vesicles (EVs) that can be isolated from ascites and blood of HGSC patients are such promising biomarkers. Epithelial cell adhesion molecule (EpCAM) expression is upregulated in most epithelium-derived tumors; however, studies on prognostic value of EpCAM overexpression in ovarian carcinoma have shown contradictory results.

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  • * Reverse Phenotyping (RP) proved crucial for refining diagnoses, especially in patients who previously had negative genetic tests, highlighting the complexity of genetic conditions associated with DD/ID.
  • * The research shows that WES can identify various genetic causes and suggests that using RP, combined with neural network models, can significantly improve diagnostic accuracy and patient management in pediatric genetics.
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  • The study aimed to determine whether the modified 28-joint disease activity index (DAPSA28) or the 28-joint disease activity score with C-reactive protein (DAS28-CRP) is better for monitoring disease activity in psoriatic arthritis (PsA) when the full joint count is unavailable.
  • Analysis of real-world data from over 3,000 European patients revealed that at the 6-month mark, DAPSA28 provided similar remission rates to DAPSA, but DAS28-CRP showed significantly higher rates of both remission and response.
  • The results suggest that DAPSA28 is preferable to DAS28-CRP when conducting assessments without a full joint count due to the
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