2 results match your criteria: "University Medical Center of The JGU Mainz[Affiliation]"
Letter to the Editor regarding "Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based calibration".
Anal Bioanal Chem
August 2021
Hochschule Fresenius University of Applied Sciences, Limburger Straße 2, 65510, Idstein, Germany.
The anti-apoptotic PON2 protein is Wnt/β-catenin-regulated and correlates with radiotherapy resistance in OSCC patients.
Oncotarget
August 2016
Department of Pharmacology, University Medical Center of The JGU Mainz, 55131 Mainz, Germany.
Article Synopsis
- Aberrant Wnt signaling and anti-apoptotic mechanisms play crucial roles in cancer, particularly in leukemia and oral squamous cell carcinoma (OSCC), highlighting the importance of the enzyme Paraoxonase-2 (PON2) in these processes.
- Researchers discovered a novel regulation of PON2 through the Wnt/GSK3β/β-catenin pathway, confirmed by various studies, showing a significant connection between PON2 and β-catenin levels in OSCC tissues.
- The findings suggest that elevated PON2 expression is linked to cancer relapse and therapy resistance, proposing PON2 as a potential new biomarker for prognosis and treatment challenges in cancer.