13 results match your criteria: "University Medical Center of Saarland[Affiliation]"
The Outcomes of Pediatric, Adolescent, and Young Adult Oncology Patients With Non-neutropenic Fever: A Scoping Review of the Literature.
Curr Pediatr Rev
January 2025
University Medical Center of Saarland, Department of Pediatric Hematology and Oncology, Kirrberger Straße, Building 9, 66421, Homburg/Saar, Germany.
Background: There are established and well-followed guidelines for pediatric oncology patients who have neutropenic fever. However, there are no explicit criteria for this patient group, and over 50% of pediatric oncology patients with fever do not present with neutropenia.
Objective: In this scoping review, we have explored the outcomes of non-neutropenic fever in pediatric, adolescent, and young adult patients with cancer-directed treatment.
A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases.
J Neurooncol
September 2024
Department of Hematology, Oncology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.
Purpose: Brain metastases represent the most common intracranial tumors in adults and are associated with a poor prognosis. We used a personalized in vitro drug screening approach to characterize individual therapeutic vulnerabilities in brain metastases.
Methods: Short-term cultures of cancer cells isolated from brain metastasis patients were molecularly characterized using next-generation sequencing and functionally evaluated using high-throughput in vitro drug screening to characterize pharmacological treatment sensitivities.
The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma.
J Neurooncol
November 2023
Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, Germany.
Purpose: Primary brain tumors are a leading cause of cancer-related death in children, and medulloblastoma is the most common malignant pediatric brain tumor. The current molecular characterization of medulloblastoma is mainly based on protein-coding genes, while little is known about the involvement of long non-coding RNAs (lncRNAs). This study aimed to elucidate the role of the lncRNA OTX2-AS1 in medulloblastoma.
View Article and Find Full Text PDFDistended abdomen due to a pseudocyst around a ventriculoperitoneal shunt.
Wien Med Wochenschr
October 2022
Department of Pediatric Cardiology, University Medical Center of Saarland, Homburg, Germany.
Article Synopsis
- A 4-year-old boy with a VP shunt from premature birth experienced abdominal distension due to a large pseudocyst.
- Physical exams and imaging tests showed tenderness, leukocytosis, and cranial displacement of his large intestine but an intact shunt.
- Surgical intervention involved revising the VP shunt and removing 2.5 liters of cerebrospinal fluid, leading to a full recovery for the patient.
A proposed biomechanical scale for the diagnosis of corneal ectatic disorders.
Eur J Ophthalmol
April 2015
Department of Ophthalmology, University Medical Center of Saarland UKS, Homburg/Saar - Germany.
Risk factors for ocular hypertension after penetrating keratoplasty.
J Glaucoma
December 2014
*Department of Ophthalmology, Geneva University Hospitals HUG, Geneva Switzerland †Department of Ophthalmology, University Medical Center of Saarland UKS Homburg/Saar, Germany.
Diagnostic capacity of biomechanical indices from a dynamic bidirectional applanation device in pellucid marginal degeneration.
J Cataract Refract Surg
June 2014
From the Department of Ophthalmology (Labiris, Song, Seitz, Gatzioufas), University Medical Center of Saarland UKS, Homburg/Saar, Germany; the Eye Institute of Thrace (Labiris, Giarmoukakis, Sideroudi, Kozobolis,), Alexandroupolis, Greece.
Article Synopsis
- The study aimed to assess the effectiveness of the keratoconus match index (KMI) and keratoconus match probability (KMP) in diagnosing pellucid marginal degeneration (PMD) using data from an Ocular Response Analyzer.
- Researchers compared KMI and KMP results between PMD eyes and normal eyes, discovering significant discrepancies and strong correlations with corneal parameters.
- The findings suggest that KMI is a reliable diagnostic tool for PMD, while the KMP's ability to categorically identify PMD cases is limited, as it labeled a significant number as normal.
Diagnostic capacity of the keratoconus match index and keratoconus match probability in subclinical keratoconus.
J Cataract Refract Surg
June 2014
From the Department of Ophthalmology (Labiris, Gatzioufas, Seitz), University Medical Center of Saarland UKS, Homburg/Saar, Germany; the Eye Institute of Thrace (Labiris, Giarmoukakis, Sideroudi, Kozobolis), Alexandroupolis, Greece.
Article Synopsis
- The study evaluated the diagnostic ability of the Ocular Response Analyzer's keratoconus match index (KMI) and match probability (KMP) in identifying keratoconus in suspect eyes compared to normal eyes.
- Conducted at the University Clinics Saarland, researchers compared KMI and KMP values among two groups: keratoconus-suspect eyes and a control group, utilizing various measures such as corneal thickness and ROC curves for predictive accuracy.
- Results indicated the KMI was significantly lower in keratoconus-suspect eyes versus controls (0.41 vs. 0.94), with a predictive accuracy of 94%, suggesting that KMI is useful for early diagnosis of kerat
Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma.
Eye (Lond)
April 2014
Department of Ophthalmology, University Medical Center of Saarland UKS, Homburg/Saar, Germany.
Background: To quantify the corneal subbasal nerve density and the total number of nerve fibers in primary congenital glaucoma (PCG) and to evaluate their impact on corneal sensitivity.
Methods: Forty eyes of 26 PCG patients were compared with 40 eyes randomly selected from 40 non-glaucoma patients who populated the control group. Central corneal sensitivity (CCS) was assessed by means of Cochet-Bonnet esthesiometry.
Biomechanical diagnosis of keratoconus: evaluation of the keratoconus match index and the keratoconus match probability.
Acta Ophthalmol
June 2013
Department of Ophthalmology, University Medical Center of Saarland UKS, Homburg/Saar, Germany.
Purpose: To evaluate the diagnostic capacity of the Ocular Response Analyser's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC) patients.
Methods: Keratoconus match index and KMP from 114 KC eyes, randomly selected from 114 patients with bilateral keratoconus (KCG), were compared with the corresponding ones from 109 normal eyes (CG). Keratoconus match index's predictive accuracy was assessed by receiver operating curves (ROC).
Elevated intraocular pressure in the early postoperative period following excimer laser penetrating keratoplasty for keratoconus.
Ophthalmic Surg Lasers Imaging
October 2013
Department of Ophthalmology, University Medical Center of Saarland UKS, Saar, Germany.
Article Synopsis
- * Conducted on 40 keratoconus patients, the research involved measuring corneal thickness, chamber depth, chamber volume, and angle before and two months after surgery, with IOP assessed using a specific tonometry method.
- * Results showed a significant increase in IOP post-surgery, with notable correlations found between elevated IOP and changes in anterior chamber parameters, suggesting that these structural changes can impact eye pressure following surgery.
Results of excimer laser penetrating keratoplasty in aphakic eyes.
Graefes Arch Clin Exp Ophthalmol
April 2013
Department of Ophthalmology, University Medical Center of Saarland, Kirrbergerstr. 22, Saarland 66421, Germany.
Background: Corneal grafting in aphakic eyes is often challenging. We report about the outcome of excimer laser trephination in aphakic eyes.
Methods: We examined 17 eyes of 17 patients.
Biomechanical profile of the cornea in primary congenital glaucoma.
Acta Ophthalmol
February 2013
Department of Ophthamology, University Medical Center of Saarland UKS, Homburg/Saar, Germany.
Purpose: The aim of our study was to investigate the biomechanical properties of the cornea in primary congenital glaucoma (PCG) and to identify the potential ocular determinants, which affect the corneal biomechanical metrics.
Methods: Corneal hysteresis (CH), corneal resistance factor (CRF) and central corneal thickness (CCT) were measured in 26 patients with PCG (40 eyes) with the aid of ocular response analyser. In vivo laser-scanning confocal microscopy was used for the estimation of stromal keratocyte density (KD) and the evaluation of corneal endothelium.