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Predisposition of spontaneously hypertensive rats to develop renal injury during nitric oxide synthase inhibition.
Eur J Pharmacol
January 2001
Department of Nephrology and Hypertension, University Medical Center (Room F03.226), P.O. Box 85500, 3508 GA, Utrecht, Netherlands.
Chronic nitric oxide (NO) synthase (NOS) inhibition results in renal injury. Hypertension is an important risk factor for renal injury. We studied the influence of preexistent hypertension on the sensitivity for renal injury induced by chronic NOS inhibition in rats.
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