Babesia bigemina and Theileria annulata infections in cattle: molecular detection, phylogenetic analysis, and assessment of risk factors.

Babesia bigemina and Theileria annulata are tick-borne protozoans that cause piroplasmosis in cattle, resulting in huge damages to the livestock industry. The prevalence of these infections depends on various intrinsic and extrinsic risk factors. In Pakistan, there is no information regarding the molecular characterization of Babesia bigemina and the risk factors associated with piroplasmosis.

Unlocking the in vitro and in vivo antioxidant and anti-inflammatory activities of polysaccharide fractions from seed-coat mucilage.

Inflammation coupled with oxidative stress contribute to the pathogenicity of various clinical disorders. Oxidative stress arises from an imbalance between production of reactive oxygen species (ROS) and antioxidant defense system, leading to cellular damages. The study investigated the antioxidant and anti-inflammatory effects of polysaccharides isolated from seed-coat mucilage.

Boron toxicity in plants: understanding mechanisms and developing coping strategies; a review.

Boron is essential for plants, but excess can induce toxicity. Boron (B) is a vital micronutrient for plants, but excess B can induce toxicity symptoms and reduce crop yields. B bioavailability depends on soil properties, including clay type, pH, and organic matter content.

Optimal features selection in the high dimensional data based on robust technique: Application to different health database.

Bio-informatics and gene expression analysis face major hurdles when dealing with high-dimensional data, where the number of variables or genes much outweighs the number of samples. These difficulties are exacerbated, particularly in microarray data processing, by redundant genes that do not significantly contribute to the response variable. To address this issue, gene selection emerges as a feasible method for identifying the most important genes, hence reducing the generalization error of classification algorithms.

Post-harvest bacterial contamination of fish, their assessment and control strategies.

Healthy fish populations lead to healthy aquatic ecosystems and it is our responsibility to be a part of the solution. Fish is one of the most favored foods and is suitable for people of all ages. Fish is an essential source of protein, vitamins, and minerals and a source of income for millions of people.

Oxyresveratrol reduces lipopolysaccharide-induced inflammation and oxidative stress through inactivation of MAPK and NF-κB signaling in brain endothelial cells.

Inflammatory responses and oxidative stress damage the integrity of the blood-brain barrier (BBB), which is a primary pathological modulator of neurodegenerative diseases. Brain endothelial cells are crucial components of BBB. In the present study, the effect of oxyresveratrol on lipopolysaccharide (LPS)-induced brain endothelial (bEnd.

Revealing the aromatic sonata through terpenoid profiling and gene expression analysis of aromatic and non-aromatic coconut varieties.

Aromatic coconut represents an exceptional variety of coconut known for its distinct and delightful flavor and aroma, both of which are highly cherished by consumers. Despite its popularity, there has been a lack of systematic research on aroma components and the associated synthetic genes. In this report, we developed the metabolite profiles of terpenoids by targeted metabolomics and obtained the expression profile of genes related to terpenoid biosynthesis by RNA-seq during different coconut fruit developmental stages.

Brown garlic: A nutritionally improved garlic with therapeutic value in asthma treatment modulation of S-nitrosothiols.

Nitric Oxide (NO) regulates important physiological functions. Garlic () is an important food component consumed fresh and processed for thousands of years. It has high L-arginine, which contributes to the NO system in the body.

Mixture and Non-Mixture Cure Models for the survival analysis of SARS-CoV-2 patients in Khyber Pakhtunkhwa, Pakistan.

Objective: To examine the potential difference in survival and risk of death between asymptomatic and symptomatic SARS-CoV-2 patients, controlled by age and gender for all the attendance in hospitals of Khyber Pakhtunkhwa (KP), Pakistan.

Methods: In this retrospective study, the medical records of 6273 SARS-CoV-2 patients admitted to almost all hospitals in Khyber Pakhtunkhwa during the first wave of the coronavirus outbreak from March to June 2020 were analysed. The effects of gender, age, and being symptomatic on the survival of SARS-CoV-2 patients were assessed using cure-survival models as opposed to the conventional Cox proportional hazards model.

Molecular detection of Anaplasma bovis, Candidatus Anaplasma boleense and Rickettsia spp. in ticks infesting small ruminants.

Anaplasma spp. and Rickettsia spp. are intracellular vector-borne pathogens and harbored by a wide range of ticks and vertebrate hosts.

Impact of psychological entitlement on engagement in learning activities and psychological anxiety: the mediating role of envy.

Psychological entitlement has appeared as a significant topic for research in the field of management and Psychology. From the perspective of social comparison theory, the present study aimed to investigate the impact of psychological entitlement on engagement in learning activities and psychological anxiety in the hotel industry. Furthermore, benign and malign envy were examined as an explanatory mechanism between psychological entitlement and its outcomes.

Molecularly imprinted polymer composite membranes: From synthesis to diverse applications.

This review underscores the fundamentals of MIP-CMs and systematically summarizes their synthetic strategies and applications, and potential developments. MIP-CMs are widely acclaimed for their versatility, finding applications in separation, filtration, detection, and trace analysis, as well as serving as scaffolds in a range of analytical, biomedical and industrial contexts. Also characterized by extraordinary selectivity, remarkable sensitivity, and outstanding capability to bind molecules, those membranes are also cost-effective, highly stable, and configurable in terms of recognition and, therefore, inalienable in various application fields.

Advances in agar-based composites: A comprehensive review.

This review article explores the developments and applications in agar-based composites (ABCs), emphasizing various constituents such as metals, clay/ceramic, graphene, and polymers across diversified fields like wastewater treatment, drug delivery, food packaging, the energy sector, biomedical engineering, bioplastics, agriculture, and cosmetics. The focus is on agar as a sustainable and versatile biodegradable polysaccharide, highlighting research that has advanced the technology of ABCs. A bibliometric analysis is conducted using the Web of Science database, covering publications from January 2020 to March 2024, processed through VOSviewer Software Version 1.

NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy.

The complex relationship between natural killer (NK) cells and dendritic cells (DCs) within the tumor microenvironment significantly impacts the success of cancer immunotherapy. Recent advancements in cancer treatment have sought to bolster innate and adaptive immune responses through diverse modalities, aiming to tilt the immune equilibrium toward tumor elimination. Optimal antitumor immunity entails a multifaceted interplay involving NK cells, T cells and DCs, orchestrating immune effector functions.

Dinaphthodiospyrol H: a natural α-glucosidase inhibibitor extracted from L.f.

The roots of L.f., known for their anti-inflammatory, antimicrobial and antidiabetic properties, are the source of dimeric naphthoquinones, including dinaphthodiospyrol H.

Use of Cosmetics and Adverse Cosmetic Events Among Female Nurses: Need for a Cosmetovigilance System.

Objectives: Cosmetics are known to cause adverse events in users, and there is limited information on this topic both globally and in Türkiye. This study was conducted to assess the use of cosmetics, patterns, and characteristics of adverse cosmetic events (ACEs) among female nurses.

Materials And Methods: This cross-sectional study was conducted from February to April 2022 among registered female nurses with at least 1 year of work experience in a tertiary care hospital in Adana, Türkiye.

Enviro-economic and optimal hybrid energy system: Photovoltaic-biogas-hydro-battery system in rural areas of Pakistan.

To satisfy the electricity needs of a village in Tangi, northwest Pakistan, the present research can design and evaluate the environmental and economical aspects of an optimal hybrid photovoltaic-biogas-hydropower-battery energy sustainable system (PV-BG-HP-BESS). This framework integrates various renewable energy sources, delivering a modern, efficient approach to sustainable energy solutions. The HOMER Pro software is utilized to optimize the most economical and effective hybrid energy system.

Assessment of hematological parameters in malarial suspected patients: Cross sectional study.

Background: Malaria is a Zoonotic disease, worldwide in distribution and caused by different species of plasmodium. It is a major cause of sickness and mortality in developing countries including Pakistan. This study was carried with the aim to find out the prevalence of malaria and to aware the people about this disease.

Population genetic analysis of Plasmodium vivax vir genes in Pakistan.

Plasmodium vivax variant interspersed repeats (vir) refer to the key protein used for escaping the host immune system. Knowledge in the genetic variation of vir genes can be used for the development of vaccines or diagnostic methods. Therefore, we evaluated the genetic diversity of the vir genes of P.

Unlocking daidzein's healing power: Present applications and future possibilities in phytomedicine.

Background: Cancer is one of the leading causes of death and a great threat to people around the world. Cancer treatment modalities include surgery, radiotherapy, chemotherapy, radiochemotherapy, hormone therapy, and immunotherapy. The best approach is to use a combination of several types.