1,464 results match your criteria: "University Mardan[Affiliation]"

Genetic polymorphism of Duffy binding protein in Pakistan Plasmodium vivax isolates.

Acta Trop

December 2024

Department of Parasitology and Tropical Medicine, and Institute of Medical Science, Gyeongsang National University College of Medicine, Jinju, 52727, Korea; Department of Convergence Medical Science, Gyeongsang National University, Jinju, 52727, Korea. Electronic address:

Article Synopsis
  • PvDBP is essential for the malaria parasite Plasmodium vivax to invade red blood cells by binding to a receptor called DARC, and its amino-terminal region II (PvDBPII) shows potential as a vaccine target.
  • A study of 118 P. vivax isolates from Pakistan identified 29 single nucleotide polymorphisms (SNPs), mainly in subdomains II and III of PvDBPII, with a notable 22 being nonsynonymous, indicating significant genetic variation.
  • Despite variation in amino acid changes between countries, both nucleotide diversity and patterns of natural selection in the Pakistan isolates align with those found globally, providing critical insights for developing effective vaccines against vivax malaria.
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Description of a new () (Ixodida: Argasidae) tick species from Pakistan.

Parasitology

October 2024

Epidemiology, Parasites and Vectors, Agricultural Research Council-Onderstepoort Veterinary Research, Onderstepoort 0110, South Africa.

The genus is notably diverse within the family Argasidae, comprising approximately 134 species distributed among 4 subgenera, 1 of which is the subgenus . In an earlier study, we identified distinct soft ticks as () sp., which were collected from animal shelters in Khyber Pakhtunkhwa, Pakistan.

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  • Plants face various biotic and abiotic stresses that hinder their growth and productivity, making micronutrient application essential for optimal yield, especially in leafy vegetables.
  • This study explores how different concentrations of copper sulfate (0, 75, 125, and 175 ppm) affect the growth and biochemical traits of Spinacia oleracea (spinach) and Avena sativa (oats).
  • The findings show that 75 ppm of copper sulfate boosts plant height, leaf area, and chlorophyll levels while higher concentrations, particularly 175 ppm, lead to decreased plant health and productivity, highlighting the importance of using optimal nutrient levels.
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Industrial waste and sewage deposit heavy metals into the soil, where they can remain for long periods. Although there are several methods to manage heavy metals in agricultural soil, microorganisms present a promising and effective solution for their detoxification. We isolated a rhizofungus, (GenBank Acc.

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Enhancing Growth in through the Inhibition of Charcoal Rot Disease: A Strategic Approach Using Plant Growth-Promoting Rhizobacteria.

Microorganisms

September 2024

Guangdong Key Laboratory for New Technology Research of Vegetables, Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510642, China.

is a vital seed and soil-borne phytopathogen responsible for substantial crop yield losses. Although various methods exist for managing soil-borne pathogens, such as agronomic practices, chemical treatments, and varietal tolerance, biological control utilizing plant growth-promoting rhizobacteria (PGPR) or their secondary metabolites presents promising avenues. In this study, a screening of 150 isolates from the rhizosphere of L.

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Evaluating the Efficacy of Plant Extracts in Managing the Bruchid Beetle, (Coleoptera: Bruchidae).

Insects

September 2024

Institute of Environment and Ecology, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.

An estimated 2000 plant species have been employed for pest control worldwide. The use of these botanical derivatives is thought to be one of the most cost-effective and sustainable options for pest management in stored grain. The present study was designed to assess the efficacy of five plant extracts viz; L.

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Metabolic Proteins Expression Up-Regulated in Blood-Borne Extensively Drug-Resistant Typhi Isolates from Pakistan.

Medicina (Kaunas)

August 2024

Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Article Synopsis
  • * A total of 1267 proteins were identified, with 37 showing differential regulation—28 proteins were up-regulated, primarily involved in metabolic processes, while 9 proteins were down-regulated, linked to carbon metabolism and amino acid biosynthesis.
  • * Most of the differentially expressed proteins were predicted to be antigenic and associated with resistance data, providing insights into the molecular mechanisms underlying the emergence of XDR Typhi.
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  • Tick-borne bacteria Rickettsia and Coxiella are linked to emerging diseases in humans and animals, and the Hyalomma ticks are known vectors for these pathogens.
  • A study in Pakistan identified seven species of ticks infesting transhumant camels and conducted molecular assays to detect the presence of Rickettsia and Coxiella.
  • The results showed the detection of Rickettsia aeschlimannii, Candidatus Rickettsia shennongii, and Coxiella burnetii, highlighting the potential health risks posed by these ticks to humans.
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This study solves the coupled fractional differential equations defining the massive Thirring model and the Kundu Eckhaus equation using the Natural transform decomposition method. The massive Thirring model is a dynamic component of quantum field theory, consisting of a coupled nonlinear complex differential equations. Initially, we study the suggested equations under the fractional derivative of Caputo-Fabrizio.

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This present study reports the biogenic synthesis of silver nanoparticles (AgNPs), gold nanoparticles (AuNPs) and Ag/Au bimetallic nanoparticles (BNPs) using bark extract of plant (T.A). The bark extract contained total polyphenolic compounds and total flavonoids as 0.

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The primary objective was to evaluate the toxicity of triflumezopyrim (TFP) on P. fuscipes larvae and adults at lethal and sublethal levels through topical application. Sublethal effects were assessed by examining developmental period, fecundity, life-table parameters, and fitness parameters.

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Article Synopsis
  • - The cowpea is a significant legume widely cultivated in Africa and Asia, recognized for its traditional roles in disease management, animal feed, and human consumption.
  • - The review highlights various compounds found in cowpea, such as flavonoids and alkaloids, which have demonstrated a range of pharmacological effects, including antibacterial and antioxidant properties.
  • - Overall, the study urges further research on cowpea's health benefits and nutritional value to better understand its potential clinical applications.
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Babesia bigemina and Theileria annulata are tick-borne protozoans that cause piroplasmosis in cattle, resulting in huge damages to the livestock industry. The prevalence of these infections depends on various intrinsic and extrinsic risk factors. In Pakistan, there is no information regarding the molecular characterization of Babesia bigemina and the risk factors associated with piroplasmosis.

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Inflammation coupled with oxidative stress contribute to the pathogenicity of various clinical disorders. Oxidative stress arises from an imbalance between production of reactive oxygen species (ROS) and antioxidant defense system, leading to cellular damages. The study investigated the antioxidant and anti-inflammatory effects of polysaccharides isolated from seed-coat mucilage.

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Boron toxicity in plants: understanding mechanisms and developing coping strategies; a review.

Plant Cell Rep

September 2024

Guangdong Engineering and Technology Center for Environmental Pollution Prevention and Control in Agricultural Producing Areas, College of Resources and Environment, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.

Boron is essential for plants, but excess can induce toxicity. Boron (B) is a vital micronutrient for plants, but excess B can induce toxicity symptoms and reduce crop yields. B bioavailability depends on soil properties, including clay type, pH, and organic matter content.

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Article Synopsis
  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Bio-informatics and gene expression analysis face major hurdles when dealing with high-dimensional data, where the number of variables or genes much outweighs the number of samples. These difficulties are exacerbated, particularly in microarray data processing, by redundant genes that do not significantly contribute to the response variable. To address this issue, gene selection emerges as a feasible method for identifying the most important genes, hence reducing the generalization error of classification algorithms.

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Post-harvest bacterial contamination of fish, their assessment and control strategies.

Braz J Biol

September 2024

University of South Bohemia in České Budějovice, Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, Laboratory of Reproductive Physiology, Vodňany, Czech Republic.

Healthy fish populations lead to healthy aquatic ecosystems and it is our responsibility to be a part of the solution. Fish is one of the most favored foods and is suitable for people of all ages. Fish is an essential source of protein, vitamins, and minerals and a source of income for millions of people.

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  • Test anxiety (TA) is a common feeling students have during exams, and it can affect their emotions and performance.
  • A study looked at how TA impacts the oral bacteria of medical students who often have a lot of stress.
  • The results showed that many students had anxiety during exams, which changed their mouth bacteria by decreasing good bacteria and increasing harmful ones, and this effect was different between boys and girls.
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Oxyresveratrol reduces lipopolysaccharide-induced inflammation and oxidative stress through inactivation of MAPK and NF-κB signaling in brain endothelial cells.

Biochem Biophys Rep

December 2024

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.

Inflammatory responses and oxidative stress damage the integrity of the blood-brain barrier (BBB), which is a primary pathological modulator of neurodegenerative diseases. Brain endothelial cells are crucial components of BBB. In the present study, the effect of oxyresveratrol on lipopolysaccharide (LPS)-induced brain endothelial (bEnd.

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Revealing the aromatic sonata through terpenoid profiling and gene expression analysis of aromatic and non-aromatic coconut varieties.

Int J Biol Macromol

September 2024

Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences/Hainan Key Laboratory of Tropical Oil Crops Biology, Wenchang, Hainan, China; Hainan Coconut International Joint Research Center, Wenchang 571339, China. Electronic address:

Aromatic coconut represents an exceptional variety of coconut known for its distinct and delightful flavor and aroma, both of which are highly cherished by consumers. Despite its popularity, there has been a lack of systematic research on aroma components and the associated synthetic genes. In this report, we developed the metabolite profiles of terpenoids by targeted metabolomics and obtained the expression profile of genes related to terpenoid biosynthesis by RNA-seq during different coconut fruit developmental stages.

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Nitric Oxide (NO) regulates important physiological functions. Garlic () is an important food component consumed fresh and processed for thousands of years. It has high L-arginine, which contributes to the NO system in the body.

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Article Synopsis
  • Mentha arvensis, also known as peppermint, was studied for its toxic and repellent effects using essential oil (MaEO) on the cockroach Nauphoeta cinerea at various concentrations.
  • The study utilized gas chromatography-mass spectrometry (GC-MS) to identify major compounds in MaEO, revealing that menthol is the predominant component at 71.31%.
  • Results showed that MaEO decreased oxidative stress markers like lipid peroxidation and non-protein thiols, while key compounds indicated potential analgesic properties through molecular docking studies.
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