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Shining light on cell death processes - a novel biosensor for necroptosis, a newly described cell death program.
Biotechnol J
February 2014
Laboratoire de Régulation des Signaux de Division, EA4479, University Lille 1, Villeneuve d'Ascq, France; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Molecular Signaling and Cell Death Unit, Inflammation Research Center, VIB, Ghent, Belgium; IRI CNRS USR 3078, University Lille 1-University Lille 2, Villeneuve d'Ascq, France; Groupement de Recherche Microscopie Imagerie du Vivant, GDR2588 MIV-CNRS, Villeneuve d'Ascq, France.
Cell death contributes to the maintenance of homeostasis, but mounting evidence has confirmed the involvement of programmed cell death in some diseases. The concept of programmed cell death, which was coined several decades ago to refer to apoptosis, now also encompasses necroptosis, a newly characterized cell death program. Research on programmed cell death has become essential for the development of some new therapies.
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