1,504 results match your criteria: "University Lille[Affiliation]"

Protocol for generating a co-culture of macrophages with breast cancer tumoroids.

STAR Protoc

December 2024

University Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France; Equipe Labellisée Ligue Contre le Cancer, Lille, France. Electronic address:

Cancer progression and treatment outcomes are heavily influenced by the tumor microenvironment (TME), especially through immune cell interactions. Here, we present a protocol for generating co-cultures of tumoroids with macrophages, either semi-liquid or Matrigel-embedded. We describe steps for macrophage preparation, co-culture establishment, and medium adjustments to support cell viability and function.

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Background: Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual anatomic variants. In 2016, increasing numbers of procedures began to be performed, and in several centers, it is now offered as a standard of care option alongside surgical repair.

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This article describes an approach to making highly stable copper nanowire networks on any type of substrates. These nanostructured materials are highly sought after for, among other applications, the development of next-generation flexible electronics. Their high susceptibility to oxidation in air currently limits their use in the real world.

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Since the pionneer work of Meerwaldt and the Groningen team, who related skin autofluorescence (SAF) to the dermal concentrations of advanced glycation end-products (AGEs), hundreds of articles have been devoted to its application in diabetes. Due to the slow turnover of the AGEs formed on collagen of the skin, the SAF can reflect the progressive accumulation of AGEs and hence be a marker of long-term glucose exposure. Accordingly, relations with HbA1c from the previous 3-10 years have been established in both type 1 and type 2 diabetes, and even in gestational diabetes mellitus.

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The roots of the Institut Pasteur's "Grand Cours".

Res Microbiol

December 2024

Department of Neurology, Catholic Institute Hospital Group Lille, GHICL 115 Rue Du Grand but, 59462, Lomme cedex, France.

The article presents an analysis of the history of the microbiology course delivered during the inaugural operational year of the Institut Pasteur in Paris. The year 1889 is examined through the lens of three hitherto unknown volumes that bring together the microbiology lectures delivered at the end of the 19th century. The course was entirely independent from the teaching provided by the universities or faculties of medicine and rapidly gained international recognition.

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Digital Outcomes as Biomarkers of Disease Progression in Early Parkinson's Disease: A Systematic Review.

Mov Disord

November 2024

Department of Neurosciences, Clinical Investigation Center CIC 1436, Parkinson Toulouse Expert Centre, NS-Park/FCRIN Network and NeuroToul COEN Center, Toulouse University Hospital, INSERM, University of Toulouse 3, Toulouse, France.

Outcomes derived from digital health technologies (DHTs) are promising candidate markers for monitoring Parkinson's disease (PD) progression. They have the potential to represent a significant shift in clinical research and therapeutic development in PD. However, their ability to track disease progression is yet to be established.

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Pesticides and risk of pancreatic adenocarcinoma in France: a nationwide spatiotemporal ecological study between 2011 and 2021.

Eur J Epidemiol

November 2024

ULR 2694-METRICS: Évaluation Des Technologies de Santé Et Des Pratiques Médicales, University of Lille, CHU Lille, 59000, Lille, France.

While pancreatic adenocarcinoma (PA) incidence is increasing, especially in France, the association between pesticides and PA remains unclear. The aims of this study were to assess the spatiotemporal distribution of the incidence of PA in France between 2011 and 2021 and to determine whether pesticide exposure was associated with higher risk of PA. We employed a disease-mapping and ecological regression approach with medicoadministrative data covering 99% of the French population.

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Background: Serum PSA and digital rectal examination remain the key diagnostic tools for detecting prostate cancer. However, due to the limited specificity of serum PSA, the applicability of this marker continues to be controversial. Recent use of image-guided biopsy along with pathological assessment and the use of biomarkers has dramatically improved the diagnosis of clinically significant cancer.

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Aim: Most of the literature on the environmental impact of surgery has analysed operating theatre practice in terms of its contribution to global warming (by greenhouse gas effects). The aim of this study was to assess the overall environmental impact of a complete perioperative pathway with and without implementation of an enhanced recovery programme (ERP).

Method: We compared two scenarios: an ERP scenario and a conventional scenario (CONV) for colorectal surgery.

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There is a body of evidence that ultrafine particles (UFP, those with diameters ≤ 100 nm) might have significant impacts on health. Accordingly, identifying sources of UFP is essential to develop abatement policies. This study focuses on urban Europe, and aims at identifying sources and quantifying their contributions to particle number size distribution (PNSD) using receptor modelling (Positive Matrix Factorization, PMF), and evaluating long-term trends of these source contributions using the non-parametric Theil-Sen's method.

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Introduction: Beyond the memory deficits classically observed in individuals with alcohol use disorder (IwAUD), research has recently focused on the study of autobiographical memory (AM) processes in IwAUD by analysing the content of AM narratives, and the implications for self-conception have been discussed. However, little is known about how IwAUD subjectively experience autobiographical recall.

Methods: Thirty-seven IwAUD and 37 control participants were invited to perform an AM task that involved recalling memories for 4 life periods (2 important memories per period).

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Reaction of F Atoms with Carbonyl Sulfide: Experimental and Theoretical Study.

Molecules

October 2024

IMT Nord Europe, Institut Mines-Télécom, Centre for Energy and Environment, University Lille, 59000 Lille, France.

The gas phase reaction of fluorine atoms with carbonyl sulfide, F + OCS → SF + CO (1), has been investigated over a wide temperature range, T = 220-960 K, in a discharge-flow system combined with mass spectrometry for the analysis of the reactive mixture. The reaction rate coefficient was determined as a function of temperature using both absolute (under pseudo-first-order conditions using an excess of F atoms) and relative rate methods: = (8.95 ± 0.

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Transesophageal echocardiography (TEE) is a vital diagnostic tool in clinical practice, particularly in transcatheter interventions where it aids in both pre-operative planning and intra-operative guidance. Traditional TEE probes often require general anesthesia due to patient discomfort. However, the development of miniaturized TEE probes presents a promising alternative, enabling routine examinations and interventions with minimal sedation.

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Aim: To evaluate the impact of corneas from donors over 80 years of age on the activity of the North of France Tissue Bank and to determine the potential cost implications for banks using corneas from older donors.

Methods: We analyzed data from a single-center retrospective cohort study of 6,023 corneas preserved at the Lille Tissue Bank between 2012 and 2023. Donors, unrestricted by age, were divided into two groups: younger (≤ 80 years) and older (> 80 years).

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Current trend in air pollution exposure and stroke.

Curr Opin Neurol

November 2024

University Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France.

Article Synopsis
  • Stroke is the second leading cause of death globally, with particulate air pollution recognized as a significant risk factor, and ongoing research is focused on its varied impacts on stroke outcomes.
  • Recent findings show that both short-term and long-term exposure to nitrogen dioxide and ozone are linked to increased stroke morbidity and mortality, and that the effects vary depending on pollutant combinations, sources, stroke types, and individual characteristics.
  • While the connection between stroke and air pollution is established, future studies need to explore the specific properties of pollutants, assess multiple exposure scenarios, individual vulnerabilities, and utilize advanced statistical methods for deeper insights.
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GALEN ANACARE consensus statement: Potential of omalizumab in food allergy management.

Clin Transl Allergy

November 2024

Division of Allergy and Immunology, Department of Dermatology, Allergy and Venerology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Article Synopsis
  • IgE-mediated food allergies are the most common type, causing quick and serious reactions that affect patients' and caregivers' lives.
  • Omalizumab is a humanized monoclonal antibody that binds to IgE, reducing allergic reactions, and has been approved by the FDA for treating these food allergies.
  • The GALEN ANACARE Consensus Statement supports omalizumab's use based on a systematic review and expert agreement, noting it is currently the only drug that can significantly reduce IgE-mediated food allergic reactions, although more evidence is needed for stronger guideline recommendations.
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Risk of Incident Cancer in Patients with Inflammatory Bowel Disease with Prior Breast Cancer: A Multicenter Cohort Study.

Clin Gastroenterol Hepatol

November 2024

Department of Gastroenterology, Bicêtre University Hospital, AP-HP, Universite Paris Saclay, INSERM CESP, Le Kremlin Bicêtre, Le Kremlin Bicêtre, France.

Background & Aims: Breast cancer is the most common malignancy observed in patients with inflammatory bowel diseases (IBD). The aim of our study was to evaluate incident cancer rate (recurrence or new-onset cancer) in a cohort of patients with IBD with a history of breast cancer according to the subsequent IBD treatment provided.

Methods: A multicenter retrospective study included consecutive patients with IBD with prior breast cancer.

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Population Genomics Reveals Demographic History and Climate Adaptation in Japanese Arabidopsis halleri.

Plant Cell Physiol

November 2024

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

Climate oscillations in the Quaternary forced species to major latitudinal or altitudinal range shifts. It has been suggested that adaptation concomitant with range shifts plays key roles in species responses during climate oscillations, but the role of selection for local adaptation to climatic changes remains largely unexplored. Here, we investigated population structure, demographic history and signatures of climate-driven selection based on genome-wide polymorphism data of 141 Japanese Arabidopsis halleri individuals, with European ones as outgroups.

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Is a periprosthetic fracture a fragility fracture like another?

Joint Bone Spine

October 2024

MABlab ULR 4490, Department of Rheumatology, CHU Lille, University Lille, 59000 Lille, France. Electronic address:

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Encephalitis lethargica, an epidemic neurological illness, typically involved a severe sleep disorder and progressive parkinsonism. A century later, our understanding relies on seminal descriptions, more recent historical research and the study of small numbers of possible sporadic cases. Theories around infection, environmental toxins, catatonia and autoimmune encephalitis have been proposed.

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O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis.

Cell Death Dis

October 2024

University Lille, CNRS, Inserm, Institut Pasteur de Lille, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000, Lille, France.

Article Synopsis
  • * Researchers investigated the hexosamine biosynthetic pathway (HBP) and its role in supporting long-lived, senescent cancer cells, finding that manipulating O-GlcNAcylation can shift the cancer cells' response from senescence to apoptosis.
  • * The results suggest that combining O-GlcNAcylation inhibitors with low doses of standard chemotherapy may enhance effectiveness and reduce side effects, targeting colorectal cancer cells more specifically compared to normal tissues.
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The multi-phase oxidation of S(IV) plays a crucial role in the atmosphere, leading to the formation of haze and severe pollution episodes. We here contribute to its understanding on a molecular level by reporting experimentally determined pK values of the various S(IV) tautomers and reaction barriers for SO formation pathways. Complementary state-of-the-art molecular-dynamics simulations reveal a depletion of bisulfite at low pH at the liquid-vapor interface, resulting in a different tautomer ratio at the interface compared to the bulk.

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