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1,193 results match your criteria: "University Leipzig[Affiliation]"
Dent J (Basel)
November 2023
Charité, Center for Dental and Craniofacial Sciences, Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Campus Benjamin Franklin, 12203 Berlin, Germany.
Visual color determination (VCD) requires color competence and individual training. The aim of this study was to evaluate the deviations in students' VCD with two different reference scales. The research hypothesis was that none of the color references would provide a better result.
View Article and Find Full Text PDFAnal Bioanal Chem
February 2024
Institute of Analytical Chemistry, University Leipzig, Linnéstrasse 3, 04103, Leipzig, Germany.
Herein, we present a miniaturized chip-based HPLC approach coupled to electrospray ionization mass spectrometry utilizing temperature to achieve high-speed separations. The approach benefits from the low thermal mass of the microfluidic chip and can form an electrospray from the pre-heated mobile phase. With the help of this technology, isothermal and temperature-programmable operations up to 130°C were pursued to perform reversed-phase separations of pesticides in methanol and ethanol-containing eluents in less than 20 s.
View Article and Find Full Text PDFQuant Imaging Med Surg
December 2023
Department of Diagnostic and Interventional Radiology, University of Leipzig - Heart Centre, Leipzig, Germany.
Background: The rotational direction (RD) of helical blood flow can be classified as either a clockwise (RD) or counter-clockwise (RD) flow. We hypothesized that this simple classification might not be sufficient for analysis and a simultaneous existence of RD may occur. We utilized volumetric velocity-sensitive cardiovascular magnetic resonance imaging (4D flow MRI) to analyze rotational blood flow in the thoracic aorta.
View Article and Find Full Text PDFRSC Med Chem
December 2023
Institute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University Leipzig Germany
For decades, tamoxifen-based hormone therapy has effectively addressed oestrogen receptor positive (ER+) luminal A breast cancer. Nonetheless, the emergence of tamoxifen resistance required innovative approaches, leading to hybrid metallodrugs with several therapeutic effects besides the inhibition of oestrogen receptor α (ERα). Drawing inspiration from tamoxifen metabolite structures (4-hydroxytamoxifen and 4,4'-dihyroxytamoxifen), a phenyl ring was replaced by a bidentate 2,2'-bipyridine donor moiety to give 4-[1,1-bis(4-methoxyphenyl)but-1-en-2-yl]-2,2'-bipyridine (L), enabling coordination of bioactive transition metal compounds such as copper(ii) dichloride, yielding [CuCl(μ-Cl)(L-κ,')] (1).
View Article and Find Full Text PDFClin Chem Lab Med
June 2024
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig Medical Center, Leipzig, Germany.
Objectives: Severe hypo- and hypercalcemia are common and urgent treatment is recommended. Free calcium (fCa) is the gold standard but needs blood gas tests with challenging preanalytics. Total calcium (tCa) and calculated adjusted calcium (aCa) are readily available, but their interpretation is hampered by identical tCa and aCa cutoffs, laborious local aCa calculation and difficult comparability of calcium biomarkers.
View Article and Find Full Text PDFInt J Fertil Steril
November 2023
Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental Research Leipzig- Halle, Leipzig, Germany. Email:
In our experimental study we explored the impact of maternal reduced heme oxygenase-1 (HO-1) gene () expression on the fertilization (IVF) rate through the use of heterozygous Hmox1 knockout mice models (HET/Hmox1+/ -). Also, we hypothesized a beneficial role of gametes exposure during fertilization to carbon monoxide (CO), one of HO-1 by-products, that might be relevant for the improvement of IVF rates. IVF technique was performed by using oocytes obtained from wild-type (WT) or dams fertilized with WT, or mice-derived sperm.
View Article and Find Full Text PDFHealth Care Manag Sci
December 2023
Health Care Operations / Health Information Management, University of Augsburg, 86159, Augsburg, Germany.
We consider the problem of setting appropriate patient-to-nurse ratios in a hospital, an issue that is both complex and widely debated. There has been only limited effort to take advantage of the extensive empirical results from the medical literature to help construct analytical decision models for developing upper limits on patient-to-nurse ratios that are more patient- and nurse-oriented. For example, empirical studies have shown that each additional patient assigned per nurse in a hospital is associated with increases in mortality rates, length-of-stay, and nurse burnout.
View Article and Find Full Text PDFBMC Cardiovasc Disord
November 2023
Department of Cariology, Endodontology and Periodontology, University Leipzig, Liebigstr. 12, D 04103, Leipzig, Germany.
Objectives: Aim of this retrospective cohort study was to evaluate whether oral health parameters would be associated with infection-related parameters and overall survival of patients with severe heart failure (HF).
Methods: Patients with severe HF, heart transplantation (HTx) and left-ventricular assist device (LVAD), which underwent a full oral examination between 2017 and 2018 were included. Infection-related and survival data were assessed from the patient´s medical records.
J Neurol Surg A Cent Eur Neurosurg
November 2024
Department of Neurosurgery, University Leipzig, Leipzig, Germany.
Background: In general, sufficient anchoring of screws in the bone material ensures the intended primary stability.
Methods: Shape memory materials offer the option of using temperature-associated deformation energy in a targeted manner to compensate the special situation of osteoporotic bones or the potential lack of anchoring. An expansion screw was developed for these purposes.
Plant and soil biodiversity can have significant effects on herbivore resistance mediated by plant metabolites. Here, we disentangled the independent effects of plant diversity and soil legacy on constitutive and herbivore-induced plant metabolomes of three plant species in two complementary microcosm experiments. First, we grew plants in sterile soil with three different plant diversity levels.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2024
Leibniz Institute of Surface Engineering (IOM), Permoserstrasse 15, 04318, Leipzig, Germany.
Despite being recognized primarily as an analytical technique, mass spectrometry also has a large potential as a synthetic tool, enabling access to advanced synthetic routes by reactions in charged microdroplets or ionic thin layers. Such reactions are special and proceed primarily at surfaces of droplets and thin layers. Partial solvation of the reactants is usually considered to play an important role for reducing the activation barrier, but many mechanistic details still need to be clarified.
View Article and Find Full Text PDFChembiochem
February 2024
Institute of Bioanalytical Chemistry and, Center for Biotechnology and Biomedicine, University Leipzig, Deutscher Platz 5, 04103, Leipzig, Germany.
Diabetes mellitus, a metabolic disorder that is characterized by elevated blood glucose levels, is common throughout the world and its prevalence is steadily increasing. Early diagnosis and treatment are important to prevent acute complications and life-threatening long-term organ damage. Glycation sites in human serum albumin (HSA) are considered to be promising biomarkers of systemic glycemic status.
View Article and Find Full Text PDFAllergol Select
October 2023
Department of Dermatology and Allergology, University Hospital Giessen, Justus Liebig University Gießen, Gießen, Germany.
Transfusion
November 2023
Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany.
Background: The incorporation of anti-CD38 monoclonal antibodies (mAb) in induction regimens of newly diagnosed transplant-eligible multiple myeloma (MM) patients has been established as a new standard. However, the optimal strategy of stem cell mobilization in this context is not yet clear.
Study Design And Methods: From May 2020 till September 2022, we retrospectively reviewed patients receiving anti-CD38 mAb-based induction therapy followed by stem cell mobilization either in a steady-state protocol (SSM) using 10 μg/kg granulocyte colony-stimulating factor (G-CSF) for 5 days or in a chemotherapy-based protocol (CM) using 1-4 g/m cyclophosphamide and G-CSF.
JMIR Form Res
October 2023
Department of Psychology, Federal University of Parana, Curitiba, Brazil.
Background: The outbreak of the COVID-19 pandemic in 2020 aggravated already existing difficulties and added new challenges for students. Owing to the gap between needed and available psychological services, group interventions may offer a helpful strategy for student mental health promotion.
Objective: This study aimed to investigate the acceptability and feasibility of a 4-week online support group program designed for mental health promotion tailored to graduate students at a Brazilian public university in the context of the COVID-19 pandemic (May 2022 to June 2022).
3D Print Med
October 2023
Department Orthopedics, Trauma Surgery and Plastic Surgery, University Leipzig, Liebigstr. 20, Leipzig, 04103, Germany.
Background: Restoration of mobility of the elbow after post-traumatic elbow stiffening due to osteophytes is often a problem.
Methods: The anatomical structures were segmented within the CT-scan. Afterwards, the Multi Jet Fusion 3D-printing was applied to create the model made of biocompatible and steam-sterilizable plastic.
Front Nutr
September 2023
Institute of Sport Medicine and Prevention, University Leipzig, Leipzig, Germany.
Introduction: Obesity and physical inactivity are known to affect cancer's development and prognosis. In this context, physical aerobic and resistance training as well as a Mediterranean nutrition have been proven to have many positive health effects. The aim of this study was therefore to investigate the effect of home-based training on body composition and certain metabolic laboratory parameters.
View Article and Find Full Text PDFSignal Transduct Target Ther
October 2023
Department of Dermatology, Allergology and Venerology, University Leipzig, Leipzig, Germany.
Transfus Med Hemother
August 2023
Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Background: Near-infrared spectroscopy (NIRS) is a commonly used technique to evaluate tissue oxygenation and prevent harmful cerebral desaturation in the perioperative setting. The aims of the present study were to assess whether surgery-related anemia can be detected via NIRS of cerebral oxygen saturation and to investigate the effects of different perioperative transfusion strategies on cerebral oxygenation, potentially affecting transfusion decision-making.
Study Design And Methods: Data from the ongoing multicenter LIBERAL-Trial (liberal transfusion strategy to prevent mortality and anemia-associated ischemic events in elderly noncardiac surgical patients, LIBERAL) were used.
Vaccines (Basel)
August 2023
Department of Laboratory Medicine, Hospital St. Georg, Delitzscher Strasse 141, 04129 Leipzig, Germany.
(1) Background: Coronavirus proteins are quite conserved amongst endemic strains (eCoV) and SARS-CoV-2. We aimed to evaluate whether peptide epitopes might serve as useful diagnostic biomarkers to stratify previous infections and COVID-19. (2) Methods: Peptide epitopes were identified at an amino acid resolution that applied a novel statistical approach to generate data sets of potential antibody binding peptides.
View Article and Find Full Text PDFNutrients
September 2023
Research Institute of Health Sciences (IUNICS), University of the Balearic Islands (UIB), 07122 Palma de Mallorca, Spain.
Background: Studies about the association of carbonated/soft drinks, coffee, and tea with depression and anxiety are scarce and inconclusive and little is known about this association in European adults. Our aim was to examine the association between the consumption of these beverages and depressive and anxiety symptom severity.
Methods: A total of 941 European overweight adults (mean age, 46.
J Vet Intern Med
November 2023
Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Background: Peripheral nerve sheath tumors (PNSTs) are a group of neoplasms originating from Schwann cells or pluripotent cell of the neural crest. Therapeutic options and prognosis are influenced by their degree of malignancy and location.
Hypothesis/objectives: Identify magnetic resonance imaging (MRI) features predictive of PNST histologic grade.
Front Immunol
September 2023
Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.
Type I interferons (IFN) are pro-inflammatory cytokines which can also exert anti-inflammatory effects via the regulation of interleukin (IL)-1 family members. Several studies showed that interferon receptor (IFNAR)-deficient mice develop severe liver damage upon treatment with artificial agonists such as acetaminophen or polyinosinic:polycytidylic acid. In order to investigate if these mechanisms also play a role in an acute viral infection, experiments with the family member Rift Valley fever virus (RVFV) were performed.
View Article and Find Full Text PDF