A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionpip7lp9plmgm964m499pslahqsvs1jf9): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

University Leipzig[Affiliation] Publications | LitMetric

1,193 results match your criteria: "University Leipzig[Affiliation]"

Purpose: The reduced cardiorespiratory fitness (CRF) and functional capacity following surgical procedures and during cancer treatments is a major risk factor for morbidity and mortality among patients with cancer. We aimed to assess the impact of endurance and combined resistance exercise interventions during the postoperative rehabilitation period for patients with colorectal, breast, and prostate cancer.

Methods: A systematic search was conducted in MEDLINE Pubmed, Web of Science, and Cochrane Library until October 2023 for randomized controlled trials that assessed exercise interventions (aerobic/endurance; resistance or combined training) on postoperative patients with cancer.

View Article and Find Full Text PDF

Purpose: During the COVID-19 pandemic, an increase in loneliness as well as mental health issues was detected. However, research on the association between loneliness and mental disorders is sparse. The aim of this study was to examine loneliness and associated social and emotional factors in patients with a psychiatric disorder and to investigate potential predictors of loneliness.

View Article and Find Full Text PDF

Effective population size () is one of the most important parameters in evolutionary biology, as it is linked to the long-term survival capability of species. Therefore, greatly interests conservation geneticists, but it is also very relevant to policymakers, managers, and conservation practitioners. Molecular methods to estimate rely on various assumptions, including no immigration, panmixia, random sampling, absence of spatial genetic structure, and/or mutation-drift equilibrium.

View Article and Find Full Text PDF

TREMSUCS-TCGA - an integrated workflow for the identification of biomarkers for treatment success.

J Integr Bioinform

December 2024

Interdisciplinary Center of Bioinformatics, 9180 Leipzig University, Härtelstraße 16-18, D-04107 Leipzig, Germany.

Many publicly available databases provide disease related data, that makes it possible to link genomic data to medical and meta-data. The cancer genome atlas (TCGA), for example, compiles tens of thousand of datasets covering a wide array of cancer types. Here we introduce an interactive and highly automatized TCGA-based workflow that links and analyses epigenomic and transcriptomic data with treatment and survival data in order to identify possible biomarkers that indicate treatment success.

View Article and Find Full Text PDF
Article Synopsis
  • Stability is essential for using recombinant proteins in therapeutics and biotechnology, and deep learning methods like ProteinMPNN can help design and stabilize proteins.
  • Despite these advancements, conventional designs still struggle to outperform the stability of natural proteins, particularly those from hyperthermophiles with unique amino acid compositions.
  • The new model, HyperMPNN, effectively captures this unique composition and shows promise for designing highly thermostable proteins, achieving stability at much higher temperatures than previously possible.
View Article and Find Full Text PDF

Ethyl acetate is at present exclusively produced from fossil resources. Microbial synthesis of this ester from sugar-rich waste as an alternative is an aerobic process. Ethyl acetate is highly volatile and therefore stripped with the exhaust gas from the bioreactor which enables in situ product recovery.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine key factors that influence healthcare usage among individuals experiencing depressive symptoms, integrating insights from various relevant research areas.
  • A sample of 1,368 adults participated in an online survey, with follow-ups conducted, using statistical methods to evaluate attitudes, intentions, and actual help-seeking behaviors.
  • Findings highlighted the importance of personal perceptions and attitudes, indicating that intention to seek help was the strongest predictor of healthcare utilization, and suggesting the need for targeted public health initiatives to address these influences.
View Article and Find Full Text PDF

Class 1 major histocompatibility complexes (MHC-I), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8 to 10 amino acids, loaded into MCH-1 within the endoplasmic reticulum and then presented on the cell surface. Foreign peptides presented in this fashion activate CD8+ T cells and their immunogenicity correlates with their affinity for the MHC-1 binding groove.

View Article and Find Full Text PDF

CDKN2A/B deletions are prognostically relevant in low- and high-grade gliomas. Data on this is derived from heterogeneous series, an accurate estimation of survival risk from homozygous CDKN2A/B deletion is missing. Besides genetic testing, p16-immunohistochemistry (IHC) as a less cost intensive means for indirect detection of CDKN2A/B alterations is possible but not validated in larger datasets.

View Article and Find Full Text PDF

Background: The COVID-19 pandemic negatively affected students' mental health, increasing pre-existing psychosocial vulnerabilities. University students worldwide have presented differences in their mental health status; however, cross-country studies comparing students' mental health during the pandemic are lacking.

Aims: To investigate potential differences between university students from Brazil and those from Germany with respect to (a) depressive symptoms and alcohol and drug consumption, (b) social and emotional aspects (loneliness, self-efficacy, perceived stress, social support and resilience) and (c) attitudes towards vaccination.

View Article and Find Full Text PDF

Introduction: Thiamine-responsive megaloblastic anemia syndrome (TRMA) is a rare autosomal recessive disease with a homozygous or compound-heterozygous mutation in the SLC19A2 gene characterized by megaloblastic anemia, diabetes mellitus (DM), and sensorineural hearing loss with onset in childhood. Folic acid and vitamin B12 in serum are normal with dysplastic erythropoiesis in the bone marrow often mimicking myelodysplastic neoplasms (MDS) as a potential differential diagnosis. Thiamine substitution leads to normalization of anemia, without effects on hearing loss or DM.

View Article and Find Full Text PDF

A 6-year-old female spayed Podenco-crossbreed dog was presented with an unusual type of focal impaired awareness seizures, including sensory ataxia and postictal rest. Magnetic resonance imaging examination revealed pre- and post-contrast agent T1-weighted bilateral symmetric hyperintensities in the lentiform nuclei and globus pallidus. Repeated cerebrospinal fluid sampling showed lymphocytic pleocytosis.

View Article and Find Full Text PDF

Objective: Common spatial pattern (CSP) is a common filter technique used for pre-processing of electroencephalography (EEG) signals for imaginary movement classification tasks. It is crucial to reduce the amount of features especially in cases where few data is available. Therefore, different approaches to reduce the amount of electrodes used for CSP calculation are tried in this research.

View Article and Find Full Text PDF

Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds.

Int J Mol Sci

September 2024

Department of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

Chronic non-healing wounds are characterized by persistent inflammation, excessive matrix-degrading proteolytic activity and compromised extracellular matrix (ECM) synthesis. Previous studies showed that S100A8/A9 are strongly dysregulated in delayed wound healing and impair the proper function of immune cells. Here, we demonstrate an unrecognized pathological function of overexpression in wounds with impaired healing that directly affects ECM functions in fibroblasts.

View Article and Find Full Text PDF

JCO Primary analysis of the phase III randomized AATT study showed that younger patients with peripheral T-cell lymphoma (PTCL) consolidated with autologous or allogeneic transplantation (alloSCT) had similar event-free survival (EFS) and overall survival (OS). Seven-year EFS of patients randomly assigned to alloSCT was 38% (95% CI, 25 to 52) compared with 34% (95% CI, 22 to 47) for patients randomly assigned to autologous transplantation of hematopoietic stem cells (autoSCT); OS was 55% (95% CI, 41 to 69) and 61% (95% CI, 47 to 74). Among patients undergoing alloSCT (n = 26) or autoSCT (n = 41) on study, the cumulative progression/relapse rate was 8% (95% CI, 0 to 19) and 55% (95% CI, 35 to 74).

View Article and Find Full Text PDF
Article Synopsis
  • This study explores how a visualization system can transmit real-time patient data from ambulances to emergency trauma rooms (ETR) to enhance timely medical interventions before and after a patient arrives.
  • Researchers conducted in-depth interviews with 32 physicians from six hospitals in Germany and Switzerland to gather insights on a prototype system designed for this purpose.
  • The findings indicate that real-time data can improve workflow in ETRs, with physicians emphasizing the need for adaptable and mobile interfaces that display critical information relevant to patient care, suggesting future research should assess the system's practical application in clinical settings.
View Article and Find Full Text PDF

Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for protein sequence and expression conservation. In this study, we investigated its effect on the evolution of regulatory elements (CREs). To this end, we carefully reanalyzed the Epigenomics Roadmap data for nine fetal tissues, assigning a measure of pleiotropic degree to nearly half a million CREs.

View Article and Find Full Text PDF

Temperature-Dependent tRNA Modifications in Bacillales.

Int J Mol Sci

August 2024

Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, Härtelstraße 16-18, D-04107 Leipzig, Germany.

Article Synopsis
  • tRNA modifications play a crucial role in helping organisms adapt to temperature changes, influencing the rigidity and flexibility of the tRNA transcripts.
  • The study focused on comparing tRNA modification patterns in thermophilic, mesophilic, and psychrophilic bacteria, revealing unique profiles for each type in relation to their growth temperatures.
  • Highest tRNA modifications were found in thermophilic bacteria at optimal temperatures, while psychrophilic and mesophilic bacteria showed increased dihydrouridine (D) modifications, supporting their adaptation to colder environments.
View Article and Find Full Text PDF
Article Synopsis
  • Myeloid sarcomas (MS) are rare tumors associated with poor outcomes, and this study highlights the limited understanding of their tumor microenvironment (TME) compared to other malignancies.
  • Researchers examined HLA-I antigen expression and TME composition in 45 MS samples, finding reduced levels of HLA-I heavy chain and beta-2 microglobulin, along with an immune cell-excluded TME with fewer tissue infiltrating lymphocytes.
  • The findings suggest that immune evasion plays a significant role in MS development, indicating a need for personalized therapies targeting these immune escape mechanisms.
View Article and Find Full Text PDF

Background: Family socioeconomic indicators (education, occupation, and household income) are key determinants influencing children's physical activity (PA). This study aims to systematically review the current research about the association between family socioeconomic indicators and PA among primary school-aged children and to quantify the distribution of reported associations by childs' and parents' sex and according to analysis and assessment methods.

Methods: A systematic literature research in multiple scientific databases (MEDLINE via PubMed, Web of Science, ScienceDirect, SPORTDiscus and ERIC) was performed for literature published between 1st January 2010 and 31st March 2022.

View Article and Find Full Text PDF

This study presents the development of a miniaturized device for supercritical fluid chromatography coupled with mass spectrometry. The chip-based, modular nanoSFC approach utilizes a particle-packed nanobore column embedded between two monolithically structured glass chips. A microtee in the pre-column section ensures picoliter sample loads onto the column, while a microcross chip structure fluidically controls the column backpressure.

View Article and Find Full Text PDF