Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer.

The identification of gene-environment interactions related to breast cancer reveals the biological and molecular mechanisms underlying the disease and allows distinction of women at high risk from women at lower risk, which could decrease the morbi-mortality of this neoplasm. The current study evaluated the association between polymorphisms rs1820453 and rs11225161 of the YAP gene in women with breast cancer exposed to arsenic (As) through drinking water. The frequency of YAP rs1820453 and rs11225161 polymorphisms and As urinary levels were assessed in a total of 182 women.

Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons.

Purpose: During recent decades, several reports have suggested a decrease in semen quality and DNA damage due in part to environmental toxicants and industrial chemicals. Among these xenobiotics, polycyclic aromatic hydrocarbons (PAHs) are of particular concern because of their remarkable mutagenic and carcinogenic properties and because several experimental and epidemiological studies have reported adverse effects of PAHs on male reproductive health and DNA structure. The aim of the study was to evaluate the association between 1-hydroxypyrene (1-OHP) urinary levels and sperm quality, DNA damage and the frequency of CYP1A1, GSTT1, and GSTM1 polymorphisms.

Peripheral desmoplastic ameloblastoma: histopathological and immunohistochemical profile of a case.

In this study we present a rare case of peripheral desmoplastic ameloblastoma and discuss its clinical features, histopathology, and immunohistochemical profile. This article reports a new case of this unusual neoplasm in a 66 year-old woman in which the main complaint was an asymptomatic swelling located in the right body of mandible. Histopathological findings were similar to the two previously reported cases of this tumor.