The First Women Physicians in the History of Modern Greek Medicine: Maria Kalapothaki (1859-1941) and Aggeliki Panagiotatou (1878-1954).

In an era when medicine in Greece was dominated by men, at the end of the 19th and during the first decades of 20th century, two women, Maria Kalapothakes [in Greek: Μαρία Καλαποθάκη] (1859-1941) and Angélique Panayotatou [in Greek: Αγγελική Παναγιωτάτου] (1878-1954), managed to stand out and contribute to the evolution of medicine. Maria Kalapothakes received medical education in Paris and then she returned to Greece. Not only did she contribute to several fields of medicine, but also exercised charity and even undertook the task of treating war victims on many occasions.

Pearls of Neonatal Intertrigo in Ancient Greek and Byzantine Medicine.

Objective: Confirmation of knowledge of neonatal intertrigo in ancient Greek and Byzantine medicine.

Method: A search of Thesaurus Linguae Graecae was conducted with the following terms as key words, "syggama", "xyggauma", "paratrimma" and "ektrimma".

Results: Ancient Greek medico-philosophers introduced therapeutic measures based upon herbs and minerals, while a similar therapeutic approach was also used by the Byzantines.

Hippocratic views in the treatment of rectal prolapse.

Known since antiquity, rectal prolapse was first studied systematically by Hippocrates (460-377 BC) who recognized the predisposing factors and proposed several therapeutic approaches such as defecation positions, manual retraction and specific herbal or mineral based anti-haemorrhagic and pain-killing poultices. Hippocratic medicine avoided invasive surgical procedures probably due to a lack of knowledge in human anatomy. However, Hippocrates' views astonishingly lasted in time, presenting similarities to current medical theories on rectal prolapse.

Isolating Colchicine in 19th Century: An Old Drug Revisited.

Colchicine is a tricyclic alkaloid extracted from the herbaceous plant Colchicum autumnale. Known since antiquity for its therapeutic efficacy in the treatment of gout, colchicine was reintroduced in 19th century pharmacopeia, thanks to the work of the French chemists and pharmacists Pierre-Joseph Pelletier (1788-1842) and Joseph Bienaimé Caventou (1795-1877) who in 1819, isolated a peculiar substance in the roots of Colchicum autumnale. In 1833, the substance was further analyzed by the German pharmacist and chemist Philipp Lorenz Geiger (1785-1836), who coined the name colchicine.

Colchicum Genus in the Writings of Ancient Greek and Byzantine Physicians.

The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays.

Treating the incurables: Cancer asylums in 18th and 19th century.

For centuries several hypotheses were formulated on cancer's pathogenesis such as contagiousness, melancholy, heredity and sexuality. In the 18th and 19th century, despite the advent of medical thought and practice, cancer was considered an incurable and contagious disease. Hospitals were refusing to treat cancer patients while the social stigma which followed the disease made primordial the need for the establishment of special institutions.

Epilepsy, Theories and Treatment Inside Corpus Hippocraticum.

An archaic surgical procedure, the skull trepanning, was introduced in ancient Greece to treat brain derangement, and endured until the 18th century with the same use. Hippocrates recognized epilepsy as a common entity and categorized it as a brain disorder, removing any divine origin. He proposed that the excess of black bile and mucus is due to the infiltration of air inside the blood circulation (veins).

Hallmarks in history of esophageal carcinoma.

Esophageal cancer is one of the deadliest cancers due to its aggressive behavior and poor survival. It was mentioned in the works of ancient Chinese and Arabo-islamic physicians, centuries before the recognition of high incidence in the Asian esophageal cancer belt. Till the 19th century the disease was considered incurable and the main goal of the proposed treatments was to alleviate dysphagia and pain.

A historical overview of laryngeal carcinoma and the first total laryngectomies.

Laryngeal cancer was a well known entity since antiquity and its treatment evolved through several phases. The lack of knowledge in anatomy and pathology as well as the absence of anesthesia and proper instrumentation made the treatment almost impossible. Ancient physicians were performing laryngotomy or tracheotomy in an attempt to prevent the suffocation symptoms produced by tumoral masses.

Melancholy as a risk factor for cancer: a historical overview.

In antiquity, physicians related depression or melancholic humour to cancer's pathogenesis. Galen (130-201 AD), sustained that melancholy could give rise to a tumour and his theory was repeated by the Byzantine and Arab physicians. In the 19th century, malignancy and depression became synonymous and people attributed their cancer to sadness.

Popular palliative cancer treatments in 18th--mid 19th century.

In the 18th century cancer was an incurable disease and the only therapeutic approach was surgery which was accompanied with several life threatening complications. In the absence of effective cancer treatment, palliative approach was proposed by physicians. Compression, ligation, "cura famis" and treatment by cold were four popular treatments in the 18th century provoking an outbreak of therapeutic illusions in cancer patients and physicians, before being lost in oblivion.

Angiotensin System Blockade Combined With Calcium Channel Blockers Is Superior to Other Combinations in Cardiovascular Protection With Similar Blood Pressure Reduction: A Meta-Analysis in 20,451 Hypertensive Patients.

The authors aimed to investigate the superiority of angiotensin system blockade (angiotensin-converting enzyme [ACE] inhibitor/angiotensin receptor blocker [ARB]) plus a calcium channel blocker (CCB) (A+C) over other combination therapies in antihypertensive treatment. A meta-analysis in 20,451 hypertensive patients from eight randomized controlled trials was conducted to compare the A+C treatment with other combination therapies in terms of blood pressure (BP) reduction, clinical outcomes, and adverse events. The results showed that BP reduction did not differ significantly among the A+C therapy and other combination therapies in systolic and diastolic BP (P=.

How cold light was introduced to arthroscopy.

In 1954, in a landmark publication, H. H. Hopkins reported that images could be transmitted through glass fibers.

Eugen Bircher (1882-1956) the first knee surgeon to use diagnostic arthroscopy.

Eugen Bircher was a strong advocate of diagnostic arthroscopy as shown in several papers on the topic of internal derangements of the knee published between 1921 and 1926. During that time, he performed about 60 endoscopic procedures, which usually preceded a meniscectomy. We believe that this was the first time arthroscopy was used in a large scale for clinical purposes.

Severin Nordentoft: The first arthroscopist.

We present a recently discovered paper that witnesses to arthroscopic activity before World War I. The Proceedings of the 4lst Congress of the German Society of Surgeons at Berlin in 1912, contain a presentation entitled "Endoscopy of Closed Cavities by the Means of My Trokart-Endoscope." The author was a Danish surgeon from Aarhus named Severin Nordentoft.