1 results match your criteria: "University Institute for Clinical Microbiology and Hygiene[Affiliation]"
Mycobacterium avium Complex Infections: Detailed Phenotypic and Functional Immunological Work-Up Is Required despite Genetic Analyses.
Int Arch Allergy Immunol
September 2023
Paracelsus University Salzburg, University Institute for Clinical Microbiology and Hygiene, Salzburg, Austria.
Article Synopsis
- Cervical scrofulous lymphadenitis caused by Mycobacterium avium complex (MAC) is uncommon in immunocompetent adults, requiring thorough clinical and immune system assessments, including advanced genetic analyses.
- Two patients with lymphadenitis were studied, revealing immune system abnormalities such as lymphopenia and reduced T-cell and B-cell populations, despite normal immunoglobulin levels.
- The female patient had a specific mutation in the interferon-γ receptor, affecting immune responses, while the male patient had normal receptor levels but still showed impaired T-cell function with reduced cytokine production.