Physiological and Psychological Differences Between 20% Grade Incline Walking and Level-Grade Jogging at Isocaloric Intensity.

High-incline walking is a relatively new trend with little comparative information. This study compared physiological and psychological differences between high-incline walking at 20% grade (HIW) and level-grade jogging (LGJ) at isocaloric intensities in young adults. Twenty-two participants (M = 11, F = 11) aged 19-31 years completed the study.

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy.

Optical aberrations hinder fluorescence microscopy of thick samples, reducing image signal, contrast, and resolution. Here we introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition, applying additional dose, or introducing more optics. Our method (i) introduces synthetic aberrations to images acquired on the shallow side of image stacks, making them resemble those acquired deeper into the volume and (ii) trains neural networks to reverse the effect of these aberrations.

Lessons Learned From Clinical Trials of Immunotherapeutics for COVID-19.

The COVID-19 pandemic caused by the SARS-CoV-2 virus was arguably one of the worst public health disasters of the last 100 years. As many infectious disease experts were focused on influenza, MERS, ZIKA, or Ebola as potential pandemic-causing agents, SARS-CoV-2 appeared to come from nowhere and spread rapidly. As with any zoonotic agent, the initial pathogen was able to transmit to a new host (humans), but it was poorly adapted to the immune environment of the new host and resulted in a maladapted immune response.

NeuroSCAN: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks.

Volume electron microscopy (vEM) datasets such as those generated for connectome studies allow nanoscale quantifications and comparisons of the cell biological features underpinning circuit architectures. Quantifications of cell biological relationships in the connectome result in rich multidimensional datasets that benefit from data science approaches, including dimensionality reduction and integrated graphical representations of neuronal relationships. We developed NeuroSCAN, an online open-source platform that bridges sophisticated graph analytics from data science approaches with the underlying cell biological features in the connectome.

Effects of Different Stretching Modalities on the Antagonist and Agonist Muscles on Isokinetic Strength and Vertical Jump Performance in Young Men.

Montalvo, S, Gonzalez, MP, Dietze-Hermosa, MS, Martinez, A, Rodriguez, S, Gomez, M, Ibarra-Mejia, G, Tan, E, and Dorgo, S. Effects of different stretching modalities on the antagonist and agonist muscles on isokinetic strength and vertical jump performance in young men. J Strength Cond Res XX(X): 000-000, 2024-Exercise warm-up may include static or dynamic stretching, impacting performance differently.

Dispersal of microbes from grassland fire smoke to soils.

Wildland fire is increasingly recognized as a driver of bioaerosol emissions, but the effects that smoke-emitted microbes have on the diversity and community assembly patterns of the habitats where they are deposited remain unknown. In this study, we examined whether microbes aerosolized by biomass burning smoke detectably impact the composition and function of soil sinks using lab-based mesocosm experiments. Soils either containing the native microbial community or presterilized by γ-irradiation were inundated with various doses of smoke from native tallgrass prairie grasses.

Synthetic, self-oscillating vocal fold models for voice production researcha).

Sound for the human voice is produced by vocal fold flow-induced vibration and involves a complex coupling between flow dynamics, tissue motion, and acoustics. Over the past three decades, synthetic, self-oscillating vocal fold models have played an increasingly important role in the study of these complex physical interactions. In particular, two types of models have been established: "membranous" vocal fold models, such as a water-filled latex tube, and "elastic solid" models, such as ultrasoft silicone formed into a vocal fold-like shape and in some cases with multiple layers of differing stiffness to mimic the human vocal fold tissue structure.

A summary of the main themes and findings presented at the ASM Intermountain Branch meeting (2024).

The annual meeting for the Intermountain Branch was held in April 2024 on the campus of Brigham Young University. There were 127 branch members from Utah, Idaho, and Nevada who attended the meeting and were composed of undergraduate students, graduate or medical students, and faculty. This report highlights the diversity of, and the emerging trends in, the research conducted by American Society for Microbiology members in the Intermountain Branch.

Examination of the PET in vivo generator Ce as a theranostic match for Ac.

Purpose: The radionuclide pair cerium-134/lanthanum-134 (Ce/La) was recently proposed as a suitable diagnostic counterpart for the therapeutic alpha-emitter actinium-225 (Ac). The unique properties of Ce offer perspectives for developing innovative in vivo investigations that are not possible with Ac. In this work, Ac- and Ce-labelled tracers were directly compared using internalizing and slow-internalizing cancer models to evaluate their in vivo comparability, progeny meandering, and potential as a matched theranostic pair for clinical translation.

Disturbance of hibernating bats due to researchers entering caves to conduct hibernacula surveys.

Estimating population changes of bats is important for their conservation. Population estimates of hibernating bats are often calculated by researchers entering hibernacula to count bats; however, the disturbance caused by these surveys can cause bats to arouse unnaturally, fly, and lose body mass. We conducted 17 hibernacula surveys in 9 caves from 2013 to 2018 and used acoustic detectors to document cave-exiting bats the night following our surveys.

Exploring the PET in vivo generator Ce as a theranostic match for Ac.

Purpose: The radionuclide pair cerium-134/lanthanum-134 (Ce/La) was recently proposed as a suitable diagnostic counterpart for the therapeutic alpha-emitter actinium-225 (Ac). The unique properties of Ce offer perspectives for developing innovative in vivo investigations not possible with Ac. In this work, Ac- and Ce-labeled tracers were directly compared using internalizing and slow-internalizing cancer models to evaluate their in vivo comparability, progeny meandering, and potential as a matched theranostic pair for clinical translation.

The Impact of an 8-Week Resisted Sprint Training Program on Ice Skating Performance in Male Youth Ice Hockey Players.

Dietze-Hermosa, MS, Montalvo, S, Gonzalez, MP, and Dorgo, S. The impact of an 8-week, resisted, sprint training program on ice skating performance in male youth ice hockey players. J Strength Cond Res 38(5): 957-965, 2024-The purposes of this randomized control study were to (a) compare the effects of an on-ice versus an overground resisted sprint training intervention and a control condition and (b) identify changes in ice skating kinematics and kinetics after training intervention participation.

Blinded by the light: does heat or light enhance wild mosquito (Diptera: Culicidae) attraction to CO2-baited traps in the Great Salt Lake area?

The New Jersey Light Trap has been among the earliest trap models used for mosquito surveillance in the United States. This trap was modernized in the 1950s to the miniature CDC light trap, with the addition of CO2 following soon after. The incandescent light has the tendency to attract nontarget insects, as well as losing a substantial portion of their energy as heat.

A Comparison of Morphological, Jump, and Sprint Kinematic Asymmetries in Division I Track and Field Athletes.

Inter-limb asymmetries are the difference in performance in one limb with respect to the other. Running events in track and field are considered symmetrical while jumping and throwing events are considered asymmetrical. It is unknown if competing in these different events result in differences in inter-limb asymmetries, thus, this study compared the magnitude of jump, sprint, and morphological asymmetries in track and field athletes who compete in symmetrical and asymmetrical events.

PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response.

Poly-ethylene-glycol (PEG)-based nanoparticles (NPs) - including cylindrical micelles (CNPs), spherical micelles (SNPs), and PEGylated liposomes (PLs) - are hypothesized to be cleared in vivo by opsonization followed by liver macrophage phagocytosis. This hypothesis has been used to explain the rapid and significant localization of NPs to the liver after administration into the mammalian vasculature. Here, we show that the opsonization-phagocytosis nexus is not the major factor driving PEG-NP - macrophage interactions.

Effects of manual resistance versus weight resistance training on body composition and strength in young adults after a 14-week intervention.

Unlabelled: Manual Resistance Training (MRT) is an alternative training modality where the external resistance is provided by a spotter.

Purpose: The purpose of this study was to observe changes in body composition and muscular fitness after a 14-week MRT intervention compared to changes elicited by a Weight Resistance Training (WRT) intervention.

Methods: Eighty-four young adults were randomly assigned to either the MRT (n = 53, height 170.

Super-resolution imaging of potassium channels with genetically encoded EGFP.

The plasma membrane is a well-organized structure of lipids and proteins, segmented into lipid compartments under 200 nm in size. This specific spatial patterning is crucial for the function of proteins and necessitates super-resolution imaging for its elucidation. Here, we establish that the genetically encoded enhanced green fluorescent protein (EGFP), when combined with direct optical reconstruction microscopy (dSTORM), tracks shear- and cholesterol-induced nanoscopic patterning of potassium channels overexpressed in HEK293T cells.

Hydrothermal treatments of starch impact reaction patterns during subsequent chemical derivatization.

Differences in derivatization patterns (using a fluorescent reagent, fluorescein isothiocyanate) of wheat, pea, and potato starches between native granular (NAT) starches and their respective annealed (ANN) and heat-moisture treated (HMT) starches were investigated to reveal structural changes associated with starch hydrothermal treatments. Size-exclusion chromatography with fluorescence and refractive index detection assessed the reactivity of amylose (AM), intermediate chains (IM and IM), and amylopectin branch chains (AP, AP, and AP) within the different starches. Shifts in X-ray diffraction patterns of HMT starches and in the gelatinization properties of both ANN and HMT starches confirmed molecular rearrangement.

THE RELATIONSHIP BETWEEN WORK CHARACTERISTICS AND SUBJECTIVE WELL-BEING OF EDUCATIONAL ORGANIZATION MANAGERS AND EMPLOYEES.

Objective: Aim: To empirically investigate the relationship between work characteristics and subjective well-being of managers and employees in educational organizations.

Patients And Methods: Materials and Methods: Analysis of work characteristics was done using The Work Design Questionnaire (WDQ). The modified BBC Subjective Well-being scale (BBC-SWB) was used to analyze educational staff's well-being.

Commercial Smart Watches and Heart Rate Monitors: A Concurrent Validity Analysis.

Montalvo, S, Martinez, A, Arias, S, Lozano, A, Gonzalez, MP, Dietze-Hermosa, MS, Boyea, BL, and Dorgo, S. Smartwatches and commercial heart rate monitors: a concurrent validity analysis. J Strength Cond Res 37(9): 1802-1808, 2023-The purpose of this study was to explore the concurrent validity of 2 commercial smartwatches (Apple Watch Series 6 and 7) against a clinical criterion device (12-lead electrocardiogram [ECG]) and a field criterion device (Polar H-10) during exercise.

Incorporating the image formation process into deep learning improves network performance.

We present Richardson-Lucy network (RLN), a fast and lightweight deep learning method for three-dimensional fluorescence microscopy deconvolution. RLN combines the traditional Richardson-Lucy iteration with a fully convolutional network structure, establishing a connection to the image formation process and thereby improving network performance. Containing only roughly 16,000 parameters, RLN enables four- to 50-fold faster processing than purely data-driven networks with many more parameters.

STUDY ON SUBJECTIVE WELL-BEING OF DIFFERENT GROUPS OF POPULATION DURING THE 2022 WAR IN UKRAINE.

Objective: The aim: To explore the peculiarities of subjective well-being (psychological well-being, physical health and well-being, relationships) and total well-being of the population during the 2022 war in Ukraine. To analyze the differences in subjective well-being of different population groups during the 2022 war in Ukraine according to the socio-demographic (gender, age, marital status) and socio-professional (social sphere of the work, position) characteristics and place of residence and security (territorial location and security level).

Patients And Methods: Materials and methods: Subjective well-being was studied using the modified BBC Subjective Well-being scale (BBC-SWB).