Advancements and mechanisms of stem cell-based therapies for spinal cord injury in animals.

Spinal cord injury (SCI) is a neurodegenerative disorder of the central nervous system that can lead to permanent loss of sensation and voluntary movement beyond the affected area. Extensive preclinical and clinical trials have been conducted to evaluate the safety and effectiveness of stem cells for the treatment of various central nervous system diseases or disorders, including SCI. However, several challenges hinder nerve cell regeneration in the injured spinal cord, such as extensive cell loss, limited neural cell regeneration capacity, axonal disruption, and the presence of growth-inhibiting molecules, particularly astroglial scarring or glial scars at the injury site in chronic cases.

Molecular characterization of a novel variant of infectious bronchitis virus from field outbreaks in backyard chicken population of North East India.

Infectious bronchitis virus (IBV) causes considerable economic impacts on global poultry production. Since its emergence in early 1930, IBV continues to evolve and now exists in a wide range of antigenically and genetically distinct variants, that makes the prevention and the control of the disease both complex and challenging. Although IBV has been reported regularly from different corner of India, information about the molecular epidemiology of circulating strain in relation to clinical form of the disease is not available.

Peristaltic motion of Jeffrey fluid with nonlinear mixed convection.

Since previous few decays the consideration of non-Newtonian liquids motion due to its immense usages in medicine, biology, industrial procedures, chemistry of catalysts and in environment. Various studies examine the significance of bio-materials flow in physiological procedures to explore the cure of diagnosed symptoms of disease appearing during movement in a human physiological system. To illustrate the characteristics of physiological liquids various non-Newtonian models have been proposed, but yet no such single liquid model is exploited which describes all the properties of nonlinear behaving liquids.

Devonian-Carboniferous extension and Eurekan inversion along an inherited WNW-ESE-striking fault system in Billefjorden, Svalbard.

The Billefjorden area in central Spitsbergen hosts thick Lower-lowermost Upper Devonian, late-post-Caledonian collapse deposits presumably deformed during the Late Devonian Svalbardian Orogeny. These rocks are juxtaposed against Proterozoic basement rocks along the Billefjorden Fault Zone and are overlain by uppermost Devonian-early Permian deposits of the Billefjorden Trough, a N-S-trending Carboniferous rift basin bounded by the Billefjorden Fault Zone. We interpreted seismic reflection (also depth-converted), bathymetric, and exploration well data.

[Russian eligibility criteria prescribing menopausal hormonal hormones therapy for patients with cardiovascular and metabolic diseases. Consensus document of the Russian Cardiological Society, Russian Society of Obstetricians and Gynecologists, Russian Association of Endocrinologists, Eurasian Association of Therapists, Association of Phlebologists of Russia].

Menopausal symptoms can disrupt the life course of women at the peak of their career and family life. Currently, the most effective treatment for these manifestations is menopausal hormone therapy (MHT). The presence of cardiovascular and metabolic diseases in itself does not exclude the possibility of prescribing MHT to relieve menopausal symptoms and improve quality of life.

Empirical models for compressive and tensile strength of basalt fiber reinforced concrete.

When molten magma solidifies, basalt fiber (BF) is produced as a byproduct. Due to its remaining pollutants that could affect the environment, it is regarded as a waste product. To determine the compressive strength (CS) and tensile strength (TS) of basalt fiber reinforced concrete (BFRC), this study will develop empirical models using gene expression programming (GEP), Artificial Neural Network (ANN) and Extreme Gradient Boosting (XG Boost).

Fault tolerant trust based task scheduler using Harris Hawks optimization and deep reinforcement learning in multi cloud environment.

Cloud Computing model provides on demand delivery of seamless services to customers around the world yet single point of failures occurs in cloud model due to improper assignment of tasks to precise virtual machines which leads to increase in rate of failures which effects SLA based trust parameters (Availability, success rate, turnaround efficiency) upon which impacts trust on cloud provider. In this paper, we proposed a task scheduling algorithm which captures priorities of all tasks, virtual resources from task manager which comes onto cloud application console are fed to task scheduler which takes scheduling decisions based on hybridization of both Harris hawk optimization and ML based reinforcement algorithms to enhance the scheduling process. Task scheduling in this research performed in two phases i.

Hybrid deep learning model based smart IOT based monitoring system for Covid-19.

Recently, COVID-19 becomes a hot topic and explicitly made people follow social distancing and quarantine practices all over the world. Meanwhile, it is arduous to visit medical professionals intermittently by the patients for fear of spreading the disease. This IoT-based healthcare monitoring system is utilized by many professionals, can be accessed remotely, and provides treatment accordingly.

Its all about IFN-λ4: Protective role of IFNL4 polymorphism against COVID-19-related pneumonia in females.

Despite the pivotal role of IFN-λs in the innate immune response, the data on its genetic polymorphism in relation to COVID-19 severity are scarce and contradictory. In the present study, we aimed to determine if the presence of the most frequent functional single nucleotide polymorphisms (SNPs) of the two most important IFN-λs coding genes, namely IFNL3 and IFNL4, alters the likelihood of SARS-CoV-2-infected patients to develop more severe form of the disease. This observational cohort study involved 178 COVID-19 patients hospitalized at the University Clinical Centre Kragujevac, Serbia.

Effect of glyphosate-based herbicide roundup on hemato-biochemistry of Labeo rohita (Hamilton, 1822) and susceptibility to Aeromonas hydrophila infection.

In the present study, comprehensive research was executed to investigate the salient toxic effects of glyphosate herbicide in static water system by evaluating the haemato-biochemical profiles of Labio rohita. A challenge study against Aeromonas hydrophila was conducted to determine disease susceptibility of the fish, treated to varying concentrations of commercial-grade glyphosate herbicide. A static range finding bioassay and definitive test revealed that the 96-h LC value of glyphosate was 10.

A Multicentric Study of Different Methods of Open Surgical Cerebral Revascularization for Internal Carotid Artery Orifice Stenosis.

To analyze the long-term results of transposition of the internal carotid artery (ICA) into the lateral wall of the external carotid artery (ECA) in the presence of hemodynamically significant stenosis of the ICA. During the period from 3.10.

[Long-term results conventional and eversion carotid endarterectomy].

Objective: To analyze immediate and long-term results of conventional and eversion carotid endarterectomy (CEA) within a multicenter registry.

Material And Methods: This retrospective, multi-center, comparative study included 375 patients who underwent CEA between February 1, 2018 and February 1, 2022. Depending on the type of operation, the sample was stratified into the eversion CEA (group 1, =218) and conventional CEA with plasty of the reconstruction area with a diepoxy-treated xenopericardium patch (group 2, =157).

Variations of Redox Balance in Different Stages of Childhood Immune Thrombocytopenic Purpura.

Background:  Few previous studies indicated the role of oxidative stress in the pathogenesis of childhood idiopathic thrombocytopenic purpura (ITP), but there are little data regarding changes in redox balance in different forms of the disease, and changes after therapeutic procedures. We aimed to investigate the values of pro-oxidants and antioxidative capacity in various forms of ITP before and after the applying therapy.

Materials And Methods:  The research included 102 children, classified into the following groups: (1) newly diagnosed ITP (ndITP), (2) persistent ITP, (3) chronic ITP (chITP), and (4) control groups: (A) healthy control and (B) previously experienced ITP-healthy children who had been suffering from ITP earlier.

The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus.

Although scientific evidence has shown that natural mineral waters have potential beneficial metabolic effects, there is still very scarce data on their influence on type 2 diabetes mellitus (T2DM). The study was designed to investigate the effects of low mineral water from the "Sneznik-1/79″ source in Serbia on microbiota, metabolic, and oxidative stress parameters in patients with T2DM. In total, 60 patients with confirmed T2DM were included in the study, and they consumed "Sneznik-1/79″ water for 28 days.

The Role of Systemic Oxidative Status in Coronary Arterial and Peripheral Venous Blood of Patients with Unstable Angina Pectoris.

(1) Background: We aimed to analyze the oxidative status of patients with unstable angina pectoris (UA), as well as to determine the correlation of these parameters between coronary arterial and peripheral venous blood samples. (2) Methods: The study included 47 human subjects with UA and 45 control subjects. We performed clinical examinations, hemodynamic and coronary angiography measures.

Prognostic Value of Redox Status Biomarkers in Patients Presenting with STEMI or Non-STEMI: A Prospective Case-Control Clinical Study.

(1) Background: The aim of our study was to determine the role of oxidative stress (OS) during early evaluation of acute ST-elevated myocardial infarction (STEMI) and non-ST-elevated myocardial infarction (NSTEMI) patients in order to define the role of redox balance in profiling the development of myocardial infarction (MI). (2) Methods: This prospective observational case-control study included 40 consecutive STEMI and 39 NSTEMI patients hospitalized in the coronary care unit of the cardiology clinic at the Kragujevac Clinical Center, Serbia, between 1 January 2016 and 1 January 2017. Blood samples were collected from all patients for measuring cardio-specific enzymes at admission and 12 h after admission to evaluate systemic oxidative stress biomarkers and the activity of antioxidant enzymes.

Phosphodiesterase-5 Inhibitors as Therapeutics for Cardiovascular Diseases: A Brief Review.

Background: Three selective and most used inhibitors of PDE-5-sildenafil, vardenafil and tadalafil- have been successfully used for the treatment of erectile dysfunction. Erectile dysfunction and cardiovascular diseases might be considered as two dissimilar clinical signs of the identical systemic disease. PDE-5 inhibitors can through different models and mechanisms induce vasodilation, decrease apoptosis and cell proliferation, and they are widely present in various tissues that make them promising targets in a range of cardiovascular diseases.

Entropy optimized flow of Sutterby nanomaterial subject to porous medium: Buongiorno nanofluid model.

Owing to enhanced thermal impact of nanomaterials, different applications are suggested in engineering and industrial systems like heat transfer devices, energy generation, extrusion processes, engine cooling, thermal systems, heat exchanger, chemical processes, manufacturing systems, hybrid-powered plants etc. The current communication concerns the optimized flow of Sutterby nanofluid due to stretched surface in view of different thermal sources. The investigation is supported with the applications of external heat source, magnetic force and radiative phenomenon.

Underwater wireless sensor network-based multihop data transmission using hybrid cat cheetah optimization algorithm.

For the conservation and sustainable use of the oceanic environment, monitoring of underwater regions is ineluctable and is effectuated with the aid of an underwater wireless sensor network. It is accoutered with smart equipment, vehicles and sensors and utilized for the transmission of acquired data from the monitoring region and forwarded to the sink nodes (SN) where the data are retrieved. Moreover, data transmission from sensor nodes to SN is complicated by the aquatic environment's inherent complexities.

The Important Role of Intermuscular Adipose Tissue on Metabolic Changes Interconnecting Obesity, Ageing and Exercise: A Systematic Review.

As age increases, adipose tissue infiltrates muscle tissue and leads to sarcopenia. When excessive accumulation of adipose tissue accompanied progressive decrease in lean body mass especially visceral fat, termed as sarcopenic obesity (SO) and related metabolic intermuscular adipose tissue (IMAT) is an ectopic tissue found between muscle groups, and is distinct from subcutaneous adipose tissue. Until now, the association between IMAT and metabolic health was not understood.

Morphologic appearance of peripheral blood cells from Zovawk pigs (Sus scrofa domesticus) visualized by transmission electron microscopy.

Background: Ultrastructural information regarding the peripheral blood cells of local (Zovawk) pigs from Mizoram, India, is not available in the scientific literature.

Objectives: The present study was designed to reveal the fine structural details of the blood cells from these local pigs using a transmission electron microscope (TEM).

Methods: Blood samples were collected from 12 healthy Zovawk pigs of either sex and processed according to a standard protocol.

Dural arteriovenous fistula of the torcular herophili presenting with hydrocephalus and venous congestion in an 8-month-old child: A case report.

Dural arteriovenous fistulas (DAVFs) are direct communication between the dural arterial and venous systems. They are more common in adults. In children, they are relatively rare.