3,405 results match your criteria: "University Hospitals of Leicester NHS Trust[Affiliation]"

Article Synopsis
  • A woman in her 70s came to A&E with shortness of breath and fever after undergoing atrial flutter ablation.
  • Initial tests showed she had pleural and pericardial effusion along with elevated inflammatory markers, but chest infection and heart failure were ruled out.
  • After treatment with steroids and colchicine, her symptoms improved significantly, and later follow-up indicated that her effusions had resolved.
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Background: Shoulder range of motion (ROM) is traditionally measured using universal goniometry. However, novel devices to measure shoulder ROM digitally are becoming increasingly available. We aimed to synthesise the current evidence to answer: 1) what technologies are currently in use? 2) Are they reliable? 3) How do they compare to goniometry?

Methods: Systematic review of the literature was conducted according to PRISMA guidelines.

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Article Synopsis
  • People with HIV (PWH) have a higher risk of cardiovascular disease (CVD) compared to those without HIV, and the study aimed to evaluate their adherence to CVD medications and factors influencing non-adherence.
  • Conducted at the University Hospitals of Leicester NHS Trust, this study analyzed data from 162 PWH, with findings indicating that about one-third of patients did not have prescribed medications detected in their urine, particularly highlighting issues with lipid-lowering agents.
  • The analysis showed that a higher number of prescribed medications correlated with non-adherence, emphasizing the need for improved strategies to enhance medication compliance among PWH for better health outcomes.
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Article Synopsis
  • Bone marrow undergoes significant changes with age, transitioning from red to yellow marrow and displaying distinct histological features that can be detected by MRI, particularly through high signal intensity on T2 images due to increased free water.
  • Chronic nonbacterial osteomyelitis (CNO) is an idiopathic inflammatory condition in children, marked by nonspecific pain and variable MR imaging signs, commonly diagnosed by ruling out other conditions.
  • The review aims to outline the characteristics of CNO and distinguish it from similar conditions, including various malignancies and benign lesions that may appear on imaging.
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Discitis in children is uncommon, typically occurring between the ages of two and eight years. The etiology is not established, but it is generally considered a bacterial infection. Symptoms vary with age but commonly include irritability, refusal to walk, and back pain.

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Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis - update from 2017 to 2023.

EClinicalMedicine

September 2024

Nottingham Centre for Public Health and Epidemiology, Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Background: Antimicrobial resistance (AMR) is a critical global health concern. A previous systematic review showed that migrants in Europe are at increased risk of AMR. Since the COVID-19 pandemic there have been rapid changes in patterns of antibiotic use, AMR, and migration.

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Patients with lower socioeconomic status (SES) have poorer outcomes following acute myocardial infarction (AMI) than patients with higher SES; however, how sex modifies socioeconomic differences is unclear. Using the United Kingdom (UK) Myocardial Ischaemia National Audit Project (MINAP) registry, alongside Office of National Statistics (ONS) mortality data, we analyzed 736,420 AMI patients between 2005 and 2018, stratified by Index of Multiple Deprivation (IMD) score Quintiles (most affluent [Q1] to most deprived [Q5]). There was no significant difference in probability of in-hospital mortality in our adjusted model according to sex.

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Article Synopsis
  • A study analyzed 47 children with non-polio enterovirus (NPEV) CNS infections and compared them to 129 controls, revealing a significant drop in hospital admissions during pandemic restrictions (13% vs. 33%).
  • The median age of affected children was 41 days and they exhibited distinct clinical features: less irritability but higher rates of fever, respiratory rates, heart rates, and abnormal cerebrospinal fluid (CSF) profiles compared to controls.
  • Additionally, phylogenetic analysis indicated that the NPEVs in these cases came from various regions worldwide, including Europe, North America, South America, the Middle East, Africa, South Asia, East/Southeast Asia, and Australia
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Article Synopsis
  • The COVID-19 pandemic led to a significant increase in virtual healthcare services, prompting a review of how effective these methods are for delivering HIV care, particularly for marginalized groups.
  • A systematic review analyzed data from 4143 records, ultimately including 26 studies that primarily used videoconferencing for consultations between healthcare workers and people living with HIV (PLHIV).
  • Results showed that virtual care (VC) is generally accepted by PLHIV, with high attendance and satisfaction rates, and it effectively supports virological outcomes, highlighting the need for diverse care models and proper training for successful implementation.
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Risk factor-targeted abdominal aortic aneurysm screening: systematic review of risk prediction for abdominal aortic aneurysm.

Br J Surg

August 2024

Department of Cardiovascular Sciences, University of Leicester, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Article Synopsis
  • This study looked at how well doctors can predict who might get an abdominal aortic aneurysm, which is a problem with a blood vessel in the belly.
  • They found 37 models that try to predict this risk, but only 4 were really different and good enough to use.
  • Common risk factors include age, smoking, and health problems like high blood pressure, but none of these models have been tested in a real-world situation yet.
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Effect of different modalities of exercise on Fatty Liver Index in patients with metabolic syndrome: The RESOLVE randomized trial.

Clin Res Hepatol Gastroenterol

October 2024

CRNH, Université Clermont Auvergne, AME2P, Clermont-Ferrand, France; International Research Chair Health in Motion, Clermont Auvergne University Foundation, Clermont-Ferrand, France. Electronic address:

Article Synopsis
  • Metabolic associated liver disease (MASLD) is the most prevalent liver disease globally, particularly among individuals with metabolic syndrome, and first-line treatments focus on lifestyle changes.* -
  • A study involving 85 patients with metabolic syndrome assessed the impact of a 3-week exercise program on the Fatty Liver Index (FLI), revealing that all exercise modalities significantly improved FLI and had lasting effects.* -
  • The findings indicate that even short-duration exercise programs can enhance liver health and overall metabolic outcomes in MASLD patients, highlighting the importance of increased physical activity.*
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Intensity or volume: the role of physical activity in longevity.

Eur J Prev Cardiol

January 2025

Division of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, 4052 Basel, Switzerland.

Aims: To investigate how physical activity (PA) volume, intensity, duration, and fragmentation are associated with the risk of all-cause and cardiovascular disease mortality. To produce centile curves for PA volume and intensity representative of US adults.

Methods And Results: This study is based on the observational 2011-2014 National Health and Nutrition Examination Survey (NHANES).

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Background: National guidance recognises the key role of rehabilitation in improving outcomes for people living with chronic kidney disease. Implementation of this guidance is reliant upon an adequate and skilled rehabilitation workforce. Data relating to this is currently lacking within the UK.

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Purpose: The importance and effectiveness of palliative care (PC) in intensive care units (ICU) are known. Less is known about the implementation and integration of ICU-based PC interventions. This systematic review aims to use a modified implementation research logic model (IRLM) to identify, map, and synthesise evidence on implementation of ICU-PC (primary and/or specialist) interventions.

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Diagnosis of respiratory tract infections (RTIs), especially in primary care, is typically made on clinical features and in the absence of quick and reliable diagnostic tests. Even in secondary care, where diagnostic microbiology facilities are available, these tests take 24-48 h to provide an indication of the etiology. This multicentre study used a portable gas chromatography-ion mobility spectrometer (GC-IMS) for the diagnosis of bacterial RTIs.

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Article Synopsis
  • Axial spondyloarthritis (axSpA) is a long-term disease that can lead to heart problems and is connected to a higher chance of diabetes.
  • Researchers studied diabetes in people with axSpA to see how common it is and if they have a higher risk compared to those without the disease.
  • They found that about 7% of people with axSpA have diabetes, and those with the disease are more likely to have diabetes than those without it.
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Objective: Patient characteristics and patterns of disease in chronic limb threatening ischaemia (CLTI) have markedly changed in recent years. Urgent specialist referral and timely revascularisation are recommended in international guidelines. UK guidelines now recommend revascularisation within five days of referral for inpatients and two weeks in outpatients.

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Article Synopsis
  • * Key predictors for CHF readmission included older age (≥60 years), diabetes mellitus, valvular heart disease, and hypertension, highlighting the need for careful management of these factors.
  • * The findings suggest that integrated care addressing lifestyle and comorbidities is crucial for improving health outcomes in resource-limited settings, especially among AF patients.
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Purpose: Ibrutinib is an irreversible Bruton's tyrosine kinase inhibitor that disrupts B-cell receptor signalling. It is licensed for treatment of low-grade B-cell malignancies, including chronic lymphocytic leukaemia, mantle cell lymphoma and lymphoplasmacytic lymphoma. A few case reports in the literature suggest that uveitis may be a side effect of ibrutinib treatment.

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Biomarkers are needed to improve diagnosis, gauge progression, and evaluate treatment. Diffusion tensor imaging (DTI) is a promising biomarker for detecting microstructural alterations in the white matter tracts.

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An expert consensus on managing dupilumab-related ocular surface disorders in people with atopic dermatitis 2024.

Br J Dermatol

November 2024

Clinical Standards Unit, British Association of Dermatologists, Willan House, London W1T 5HQ, UK.

Article Synopsis
  • Atopic dermatitis (AD) is a prevalent skin condition that can occur in individuals of any age, and while dupilumab shows promising efficacy as a monoclonal antibody therapy, its use has been linked to a higher occurrence of ocular side effects.
  • The British Association of Dermatologists and the Royal College of Ophthalmologists developed guidance on how to manage these dupilumab-related ocular surface disorders (DROSD) after forming a multidisciplinary group to review literature and recommendations.
  • Key recommendations include that treatment with dupilumab should not be delayed for most eye issues, hydration drops are not advised as preventive measures, and specific guidance is provided for managing DROSD in both children under 7 and those older, with a focus on
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