3,347 results match your criteria: "University Hospitals of Leicester NHS Trust[Affiliation]"

THE APPROACH TO A PREGNANCY AFTER BARIATRIC SURGERY.

Clin Med (Lond)

December 2024

Diabetes Research Centre, Leicester NIHR Biomedical Research Centre, Leicester General Hospital, Leicester, UK; University Hospitals of Leicester NHS Trust, Leicester, UK; University of Leicester, Leicester, UK. Electronic address:

With a rising worldwide incidence of obesity, particularly in the young, bariatric surgery offers an effective method of meaningful and sustained weight loss. At present, most bariatric procedures are carried out in women and increasingly in younger age groups. In line with the fertility benefits associated with weight loss, pregnancy after bariatric surgery is now a very common scenario.

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Current evidence of arterial spin labeling in amyotrophic lateral sclerosis: A systematic review.

Clin Neurol Neurosurg

December 2024

Neuromuscular Research Center, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurology, University Hospitals of Leicester NHS Trust, Leicester, UK.

Objective: This study aimed to evaluate the utility of arterial spin labeling (ASL) in assessing cerebral blood flow (CBF) changes in amyotrophic lateral sclerosis (ALS), and its potential as a biomarker for early diagnosis.

Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies that employed ASL to compare CBF between ALS patients and healthy controls were included.

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7 days of L-citrulline supplementation does not improve running performance in the heat whilst in a hypohydrated state.

Eur J Appl Physiol

December 2024

National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

Purpose: 7 days L-citrulline supplementation has been reported to improve blood pressure, O kinetics, gastrointestinal (GI) perfusion and endurance cycling performance through increasing arterial blood flow. In situations where blood volume is compromised (e.g.

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Introduction: The Kidney BEAM randomized controlled trial reported clinically meaningful and statistically significant improvements in mental health-related quality of life (HRQoL), physical function (sit-to-stand-60, but not the physical component of HRQoL) and patient activation after a 12-week physical activity digital health intervention (DHI). This study explores factors that contributed to the effectiveness of Kidney BEAM through mixed methods analyses.

Methods: Quantitative data analysis was obtained from the recently published primary manuscript.

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Introduction: Pulsed-field ablation (PFA) is a novel modality for pulmonary vein isolation in patients with atrial fibrillation (AF). We describe the initial uptake and experience of PFA using a pentaspline catheter across selected National Health Service England (NHSE) centres.

Methods: Data collected by NHSE Specialised Services Development Programme regarding AF ablation procedures using a single-shot, pentaspline, multielectrode PFA catheter (FARAWAVE, Boston Scientific) between June 2022 and August 2024 were aggregated and analysed to examine procedural metrics, acute efficacy and safety outcomes over 3-month follow-up.

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Background: Most patients with small-cell lung cancer (SCLC) present with extensive-stage (ES) disease and have a poor prognosis despite achieving high initial response rates to platinum-based doublet chemotherapy. This study evaluated whether adding hydroxychloroquine (HCQ) to chemotherapy could improve outcomes.

Methods: This was a randomised multicentre phase II trial.

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To investigate the microstructural integrity, tract volume analysis, and functional connectivity (FC) alterations of the left uncinate fasciculus (UF) in patients with amyotrophic lateral sclerosis (ALS) compared to healthy controls (HCs). Fourteen limb-onset ALS patients were recruited at baseline and ten at follow-up, along with 14 HCs. All participants underwent 3D T1-weighted, diffusion tensor imaging and kurtosis imaging (DTI/DKI), and resting-state functional MRI (rs-fMRI) using a 3 Tesla scanner with 64-channel coils.

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Osteochondral lesions of talus.

Bone Joint Res

December 2024

Department of Mechanical Engineering, University of Bath, Bath, UK.

Cite this article:  2024;13(12):790–792.

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: Colon capsule endoscopy (CCE) is becoming more widely available across Europe, but its uptake is slow due to the need for follow-up colonoscopy for therapeutic procedures and biopsies, which impacts its cost-effectiveness. One of the major factors driving the conversion to colonoscopy is the detection of excess polyps in CCE that cannot be matched during subsequent colonoscopy. The capsule's rocking motion, which can lead to duplicate reporting of the same polyp when viewed from different angles, is likely a key contributor.

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Background: Between 1% and 4% of febrile infants, aged from birth to 90 days of age, presenting to hospital will be diagnosed with an invasive bacterial infection (IBI). Traditional teaching has advocated a treat all approach but more recently a number of clinical decision aids (CDA) have been developed to classify febrile infants into lower and higher risk cohorts, with lower risk infants suitable for management without immediate parenteral antibiotics and lumbar puncture. The aim of this study was to apply these CDA to a UK and Irish cohort.

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Stroke is a leading cause of morbidity and mortality worldwide, and early detection of risk factors is critical for prevention and improved outcomes. Traditional stroke risk assessments, relying on sporadic clinical visits, fail to capture dynamic changes in risk factors such as hypertension and atrial fibrillation (AF). Wearable technology (devices), combined with biometric data analysis, offers a transformative approach by enabling continuous monitoring of physiological parameters.

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The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study.

Lancet Oncol

December 2024

Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Faculty of Health, Medicine, and Social Care, Anglia Ruskin University, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK. Electronic address:

Background: Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine-procarbazine-prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce toxicity. We aimed to investigate the impact of this drug substitution on the mutation burden in stem cells, patient survival, and toxicity.

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Cardiology training in the UK is facing significant challenges due to a range of factors. Recent curriculum changes have further compounded this issue and significantly risk the ability to produce adequately trained consultants capable of managing patients with increasingly complex cardiovascular disease. The introduction of mandatory dual accreditation in general internal medicine (GIM) alongside cardiology, by design, results in significantly reduced training opportunities, including procedural and subspecialty exposure.

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Purpose: This study aims to perform a systematic review to determine whether ultra-high molecular weight polyethylene (UHMWPE) tapes have superior biomechanical properties compared to conventional sutures in posterior meniscal root tear (PMRT) repairs, and whether this translates into superior clinical outcomes.

Methods: The Cochrane Controlled Register of Trials, PubMed and Embase were used to perform a systematic review using the following search terms: (meniscus OR meniscal) AND (root OR posterior horn) AND (suture OR tape OR wire OR cord). Data pertaining to certain biomechanical properties (load to failure, stiffness, displacement during cyclical loading and at failure), meniscal healing and patient-reported outcome measures (PROMs) were extracted.

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Introduction: Groin discomfort is one of the most common presenting complaints in health care and often requires ultrasound to detect hernias. However, such singular emphasis leads to over diagnosing hernia and other significant aetiologies in and around the groin are overlooked.

Topic Description: The article elaborates on the key areas a sonographer needs to focus on and presents a range of conditions responsible for groin pain other than hernia.

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Article Synopsis
  • This pilot study assesses the effectiveness of the Koios Decision Supportâ„¢ AI tool in improving the accuracy of ultrasound evaluations for thyroid nodules, aiming to reduce the need for fine needle aspiration (FNA).
  • Conducted on 29 patients analyzed over a year, the study compared traditional FNA results with AI recommendations, using surgical histology as a standard reference.
  • The findings indicate that while the AI tool has a sensitivity of 85.7% and a positive predictive value of 63.2%, it also suggests that 53% of benign cases may not need FNA, highlighting the potential for AI to enhance diagnostic performance despite the sample size limitations.
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Introduction Epilepsy is a chronic disorder that requires patient education for management and to avoid triggers and complications. This study aims to evaluate and compare the effectiveness of two artificial intelligence (AI) tools, ChatGPT (version 3.5, OpenAI, Inc.

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Background Approximately 9,000 patients undergo ileostomy formation each year in England. This includes those formed in both the elective and emergency settings. Recent studies have indicated a stoma-related complication rate of up to 83%.

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Article Synopsis
  • The article describes the creation of the first ultrasound system for continuous monitoring of brain tissue pulsations (BTPs) using transcranial Doppler (TCD) technology.
  • A lightweight, wearable probe called Transcranial Tissue Doppler (TCTD) was developed to measure tissue motion and was tested successfully with existing TCD hardware.
  • The new system, Brain Tissue Velocimetry (Brain TV), can capture BTP data in real-time alongside other vital physiological measurements and shows potential for clinical assessment in healthy and stroke patients.
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Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes.

J Cardiovasc Magn Reson

December 2024

Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.

Background: Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.

Methods: Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls.

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Article Synopsis
  • The European Cancer Organisation's Essential Requirements for Quality Cancer Care (ERQCC) provide guidance on how to improve cancer treatment, focusing on ovarian cancer specifically.
  • Ovarian cancer patients experience low cure rates due to inconsistent treatment and a need for specialized care, which should be provided in dedicated centers by qualified professionals.
  • Centralized, patient-centered care throughout the entire treatment journey is essential for better outcomes but is not yet widely implemented across many European countries.
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Article Synopsis
  • Weight loss can inadvertently lead to a decrease in both lean and fat tissue, potentially causing individuals, even younger ones, to become frail rather than just improving their body composition.
  • This systematic review will evaluate the impact of nutritional supplements on maintaining lean mass during weight loss, particularly when exercise isn't an option.
  • The findings will follow PRISMA standards and will be published in a peer-reviewed journal, marking a significant contribution to understanding nutritional support during weight loss.
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Reply to: Social Worker in Clinical Management Pathways for Outcome Improvement.

Eur J Vasc Endovasc Surg

December 2024

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; Leicester Vascular Institute, University Hospitals of Leicester NHS Trust, Leicester, UK; National Institute for Health Research Leicester Biomedical Research Centre - The Glenfield Hospital, Leicester, UK.

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A 5-day-old neonate was admitted with chest radiograph showing right-lung opacification. This, together with a severe adenovirus (AdV) viremia (11.8 million copies/mL), indicated severe adenovirus pneumonitis.

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