2 results match your criteria: "University Hospitals of Aachen and Cologne[Affiliation]"
Increased maternal/fetal blood S100B levels following systemic endotoxin administration and periventricular white matter injury in preterm fetal sheep.
Reprod Sci
August 2009
Department of Obstetrics and Gynecology, University Hospitals of Aachen and Cologne, Germany.
Objective: Intrauterine infection is suggested to cause perinatal brain white matter injury. In the current study, we evaluated whether S100B, a brain damage marker, may be also assessed in maternal bloodstream after white matter injury induced by fetal intravenous application of lypopolisaccharide (LPS) endotoxin.
Methods: Fourteen fetal sheeps were chronically catheterized at a mean gestational age of 107 days.
Systemic endotoxin administration results in increased S100B protein blood levels and periventricular brain white matter injury in the preterm fetal sheep.
Eur J Obstet Gynecol Reprod Biol
January 2006
Department of Obstetrics and Gynecology, University Hospitals of Aachen and Cologne, Kerpenerstrasse 62, 50924 Cologne, Germany.
Objective: Intrauterine infection is suggested to cause perinatal brain white matter injury. The aim of the present study was to clarify, whether intravenous application of endotoxin results in neuropathological findings and increased blood levels of the S100B protein, which is a consolidated marker of brain injury.
Methods: Twenty-one fetal sheep were chronically catheterized at a mean gestational age of 107+/-1 days (0.