29 results match your criteria: "University Hospitals Research in Surgical Outcomes and Effectiveness (UH RISES)[Affiliation]"

Epigenetic aging differentially impacts breast cancer risk by self-reported race.

PLoS One

October 2024

Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.

Article Synopsis
  • Breast cancer (BrCa) is the most prevalent cancer among women worldwide, with significant variations in incidence by age and race, particularly noting that Black women face earlier onset and higher mortality rates.
  • Researchers assessed the link between epigenetic age acceleration and BrCa development by analyzing blood DNA from 149 BrCa patients and 42 healthy controls, finding that BrCa patients had a greater overall epigenetic age acceleration compared to controls.
  • Although the study suggested a correlation between higher epigenetic age and increased BrCa risk, differences in risk based on self-reported race did not yield statistically significant results due to limited sample size.
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Should breast surgery be considered for patients with de novo metastatic inflammatory breast cancer?

Am J Surg

July 2024

Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA; University Hospitals Research in Surgical Outcomes and Effectiveness (UH-RISES), Cleveland, OH, USA. Electronic address:

Article Synopsis
  • Researchers studied women with a serious form of breast cancer called stage IV inflammatory breast cancer to see why some had surgery and others did not.
  • They found that only about 29% of the patients had surgery, and being older or treated more recently made women less likely to get surgery.
  • The women who had surgery lived longer than those who didn't, so the study suggests more research is needed to figure out which stage IV patients should have surgery.
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Development of a Competency Framework Defining Effective Surgical Educators.

J Surg Educ

March 2024

Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address:

Objective: The objective of this study is to develop a practical framework of competencies and behaviors which define an effective surgical educator.

Design: A modified Delphi approach was used. A literature review and series of discussions with surgical education experts led to creation of a survey instrument which was sent to surgical faculty and trainees from a single academic institution.

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Objective: There is no consensus on the optimal anticoagulant regimen following lower extremity bypass. Historically, warfarin has been utilized for prosthetic or compromised vein bypasses. Direct-acting oral anticoagulants (DOACs) are increasingly replacing warfarin in this context, but their efficacy in bypass preservation has not been well-studied.

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Using MammaPrint on core needle biopsy to guide the need for axillary staging during breast surgery.

Surgery

March 2024

Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Research in Surgical Outcomes and Effectiveness (UH-RISES), University Hospitals Cleveland Medical Center, Cleveland, OH. Electronic address:

Article Synopsis
  • The study looked at whether a special test called MammaPrint could help decide if some women with early-stage breast cancer could skip a procedure called sentinel lymph node biopsy.
  • They focused on women over 70 years old with a specific type of breast cancer and checked their health records from 2020 to 2021.
  • The results showed that having a low-risk MammaPrint score didn’t mean a lower chance of having cancer spread to the lymph nodes, so it might not help doctors avoid the biopsy.
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Article Synopsis
  • The study looked at older women with a specific type of breast cancer to see if combining chemotherapy and hormone therapy (CET) helped them live longer than just hormone therapy (ET) alone.
  • They found that women who received CET had a higher chance of surviving for five years compared to those who only got ET, with survival rates of 95.4% for CET versus 92.0% for ET.
  • This means that adding chemotherapy is important for improving survival in older women with certain breast cancer types, even if it might cause other side effects.
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Background: Research presentation has benefits, including CV building, networking, and collaboration. A measurable standard for achievement is publication in a peer-reviewed journal. Expectations regarding the likelihood of publication are unknown for studies presented at a national surgical scientific meeting.

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Background: The RxPONDER trial found that among breast cancer patients with estrogen receptor positive (ER+) breast cancer, 1-3 positive axillary nodes, and a recurrence score of ≤25, only pre-menopausal women benefitted from adjuvant chemoendocrine therapy; postmenopausal women with similar characteristic did not benefit from adjuvant chemotherapy. We aimed to replicate the RxPonder trial using a larger patient cohort with real world data to determine whether a RS threshold existed where adjuvant chemotherapy was beneficial regardless of age.

Methods: The National Cancer Database (NCDB) was queried for women with ER+, human epidermal growth factor receptor 2 (HER2) negative breast cancer, 1-3 positive axillary nodes, and RS ≤25 who received endocrine (ET) only or chemo-endocrine therapy (CET).

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Background: Sarcopenia, defined as low skeletal muscle mass, affects up to 60% of rectal adenocarcinoma patients receiving neoadjuvant chemoradiation (NACRT), with negative impact on patient outcomes. Identifying modifiable risk factors may decrease morbidity and mortality.

Methods: A retrospective review of rectal cancer patients from a single academic center from 2006 to 2020 was performed.

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Adjuvant Therapy in Breast Cancer Patients With Microscopic Residual Disease.

J Surg Res

May 2023

University Hospitals Research in Surgical Outcomes and Effectiveness (UH-RISES) Center; Division of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address:

Introduction: Surgical resection is the gold standard for early-stage breast cancer. Positive surgical margins are associated with poor outcome. Endocrine therapy (ET) is recommended as primary systemic treatment for hormone receptor positive (HR+) breast cancer after surgery.

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Modeling the COVID Pandemic: Do Delays in Surgery Justify Using Stereotactic Radiation to Treat Low-Risk Early Stage Non-Small Cell Lung Cancer?

J Surg Res

March 2023

Division of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; University Hospitals Research in Surgical Outcomes and Effectiveness (UH-RISES), Cleveland, Ohio. Electronic address:

Introduction: It was suggested that stereotactic radiation (SBRT) is an "alternative if no surgical capacity is available" for non-small cell lung cancer (NSCLC) care during the COVID-19 pandemic. The purpose of this study was to compare the oncologic outcomes of delayed surgical resection and early SBRT among operable patients with early stage lung cancer.

Methods: The National Cancer Database was queried for patients with cT1aN0M0 NSCLC who underwent surgery or SBRT (2010-2016) with no comorbidity.

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Trends in surgery and survival for T1-T2 male breast cancer: A study from the National Cancer Database.

Am J Surg

January 2023

Division of Surgical Oncology, Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA; University Hospitals Research in Surgical Outcomes and Effectiveness (UH-RISES), USA. Electronic address:

Background: Despite evidence that early-stage male breast cancer (MBC) can be treated the same as in females, we hypothesized that men undergo more extensive surgery.

Methods: Patients with clinical T1-2 breast cancer were identified in the National Cancer Database 2004-2016. Trends in surgery type and overall survival were compared between sexes.

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Guideline-Consistent Treatment for Inflammatory Breast Cancer Provides Associated Survival Benefit Independent of Age.

Ann Surg Oncol

October 2022

Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Lakeside 7009, Cleveland, OH, 44106-5047, USA.

Background: Guideline-consistent treatment (GCT) for inflammatory breast cancer (IBC) includes neoadjuvant chemotherapy (NAC), modified radical mastectomy (MRM), and radiation. We hypothesized that younger patients more frequently receive GCT, resulting in survival differences.

Methods: Using the National Cancer Database (2004-2018), female patients with unilateral IBC (by histology code and clinical stage T4d) were stratified by age (< 50, 50-65, > 65 years).

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Objective: The objective of the study is to compare faculty and resident perspectives regarding the competencies of an outstanding surgical educator in practice.

Design: An IRB-approved survey instrument using a five-point Likert scale assessing 50 competencies and behaviors of a surgical educator was sent to study participants. The competencies and behaviors examined were within the domains of: 1) medical knowledge 2) learner-centeredness 3) interpersonal and communication skills 4) professionalism and role-modeling, and 5) intraoperative teaching.

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ASO Author Reflections: Inflammatory Breast Cancer: The Exception to De-escalation of Care for Older Women?

Ann Surg Oncol

October 2022

Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

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Age disparities in triple-negative breast cancer treatment and outcomes: An NCDB analysis.

Surgery

September 2022

Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Research in Surgical Outcomes and Effectiveness (UH-RISES), Cleveland, OH. Electronic address:

Background: Race, access to care, and molecular features result in outcome disparities in triple-negative breast cancer (TNBC). We sought to determine the role of age in TNBC disparity by hypothesizing that younger patients receive more comprehensive treatment, resulting in survival differences.

Methods: The National Cancer Database was used to identify women with unilateral TNBC treated from 2005 through 2017.

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Background: Endoscopic esophageal stenting is used as an alternative to surgical repair for esophageal perforation. Multi-institutional studies supporting stenting are lacking. The purpose of this study was to compare the outcomes of surgical repair and esophageal stenting in patients with esophageal perforation using a nationally representative database.

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Background: While neoadjuvant combined modality therapy (NA-CMT) is beneficial for most patients with locally advanced rectal cancer some patients may experience disease progression during treatment. The purpose of this study is to identify characteristics associated with progression during NA-CMT.

Methods: A single institution retrospective review of patients with stage II-III rectal cancer receiving NA-CMT was conducted from 2008-2019.

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Background: Frailty has been associated with increased morbidity after surgery. However, few studies investigate long-term functional outcomes.

Methods:  Patients ≥ 65 years old who underwent surgery for colorectal cancer were surveyed regarding their ability to perform activities of daily living, measured by Barthel Index, before and after surgery.

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The impact of a "Residents as Teachers" Workshop at one year follow-up.

Am J Surg

July 2022

University Hospitals Cleveland Medical Center, Cleveland, OH, USA; University Hospitals Research in Surgical Outcomes and Effectiveness (UH RISES), Cleveland, OH, USA. Electronic address:

Introduction: "Residents as Teachers" (RaT) Workshops have been implemented in many General Surgery residency programs to improve resident teaching ability. The aim of this project was to assess whether there was significant degradation of teaching skills and knowledge one year after a RaT workshop.

Methods: A 4-h interactive workshop was delivered at an academic general surgery residency program.

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Article Synopsis
  • The American Joint Committee on Cancer recommends reviewing at least 12 lymph nodes after rectal cancer surgery, but the connection between lymph node yield and patient prognosis remains uncertain.
  • A study analyzed data from patients with rectal adenocarcinoma who had neoadjuvant chemoradiation, focusing on their lymph node yield and survival outcomes.
  • Results indicated that patients with inadequate lymph node yield (1-11 nodes) faced a significantly higher risk of mortality compared to those with adequate yield (≥12 nodes), emphasizing the importance of lymph node assessment in predicting survival even among those with negative nodal status.
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Background Data suggests there are demographic and biological differences in colon cancer between young and typical-onset patients. However, it is unclear if these differences persist in rectal cancer patients, exclusive of colon cancer. This is a retrospective review of a large national database to evaluate age-based differences in demographics, tumor features, and treatment among patients with rectal adenocarcinoma.

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Adjuvant trastuzumab with or without chemotherapy in stage 1 pT1N0 HER2+ breast cancer: a National Cancer Database analysis.

Breast Cancer Res Treat

January 2022

Division of Hematology and Oncology, Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Purpose: Approximately 20% of all breast cancers (BC) are HER2 amplified. In the APT trial, weekly paclitaxel/trastuzumab in node negative HER2+ BC with tumors < 3 cm was associated with a 7-year invasive disease-free survival of 93%. However, this was in the context of a non-randomized trial, and for pT1N0 HER2+ BC it remains unclear whether HER2 monotherapy would provide similar clinical outcomes to chemo-HER2 therapy.

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Neoadjuvant Endocrine Therapy as an Alternative to Neoadjuvant Chemotherapy Among Hormone Receptor-Positive Breast Cancer Patients: Pathologic and Surgical Outcomes.

Ann Surg Oncol

October 2021

Division of Surgical Oncology, Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Background: Neoadjuvant chemotherapy (NCT) is considered more effective in downstaging hormone receptor-positive (HR+) breast cancer than neoadjuvant endocrine therapy (NET), particularly in node-positive disease. This study compared breast and axillary response and survival after NCT and NET in HR+ breast cancer.

Methods: Based on American College of Surgeons Oncology Group (ACOSOG) Z1031 criteria, women age 50 years or older with cT2-4 HR+ breast cancer who underwent NET or NCT and surgery were identified in the National Cancer Database 2010-2016.

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