188 results match your criteria: "University Hospitals Leicester NHS Trust[Affiliation]"
BMC Pregnancy Childbirth
December 2024
Department of Neonatology, Women and Children's Directorate, University Hospitals Leicester NHS Trust, Leicester, UK.
Aims: This expert consensus reviews the reality of primary care clinical management of people with type 2 diabetes (T2D) on non-intensive insulin therapy, with an emphasis on the use of continuous glucose monitoring (CGM) technology for effective care in this participant group. Here, we identify key unmet needs for skills and systems development within this frontline healthcare setting, along with major challenges and opportunities associated with managing these changes effectively.
Methods: The authors participated in two primary care consensus panels held on 28 November 2023 and on 21 May 2024.
Nephrol Dial Transplant
December 2024
UK Renal Registry, UK Kidney Association, Bristol, UK.
Diabetologia
December 2024
Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
J Nephrol
November 2024
Mayer IgA Nephropathy Laboratories, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
IgA nephropathy is the commonest pattern of primary glomerular disease in the world, with high rates of progression to kidney failure. As IgA nephropathy commonly causes kidney failure at a young age, kidney transplantation is commonly used to treat kidney failure. However, high rates of recurrent disease in the allograft remain a common management challenge.
View Article and Find Full Text PDFDiabet Med
January 2025
Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
Unlabelled: Dietary fibre improves glycaemic control in type 2 diabetes, but its therapeutic role in women with diabetes in pregnancy is unclear. We assessed the effect of dietary fibre on markers of glycaemic control in women with diabetes in pregnancy.
Methods: We searched four databases (Cochrane Library, MEDLINE, Embase and Web of Science) to identify RCTs exploring the effect of dietary fibre, high-fibre diets or fibre supplementation on fasting blood glucose (FBG), 2-h postprandial blood glucose (PBG) and requirement for insulin therapy, among other glycaemic makers in pregnant women with diabetes.
World J Gastrointest Endosc
September 2024
General Medicine, College of Medicine and Sagore Dutta Hospital, Kolkata 700058, India.
Kidney Int
December 2024
John Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK; Mayer IgA Nephropathy Laboratories, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. Electronic address:
Nutr Bull
September 2024
Department of Bariatric and Metabolic Surgery, North Bristol National Health Service Trust, Bristol, UK.
Diabetes Care
October 2024
Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, Cambridge, U.K.
Background: The increased risk of pregnancy complications in type 1 diabetes is mainly attributed to maternal hyperglycemia. However, it is unclear whether other potentially modifiable factors also contribute to risk in this population.
Purpose: We sought to assess whether high BMI and excessive gestational weight gain (GWG) are associated with perinatal complications in type 1 diabetes.
J Clin Orthop Trauma
July 2024
Department of Trauma and Orthopaedic Surgery, University Hospitals Leicester NHS Trust, University Hospitals of Leicester Headquarters, Level 3, Balmoral Building, Leicester, United Kingdom.
Background: Tarsal tunnel syndrome, also known as posterior tibial neuralgia, is a compressive neuropathy of the posterior tibial nerve or one of its divisions (calcaneal, lateral plantar or medial plantar nerve) within the tarsal tunnel. This scoping review aims to systematically map and summarise current literature regarding the management of tarsal tunnel syndrome.
Methods: PubMed, Embase, Emcare, Medline and Cinahl were searched using the terms 'tarsal tunnel', 'syndrome', 'entrapment', 'compression', 'posterior tibial', 'neuropathy' and 'neuralgia.
Nephrol Dial Transplant
December 2024
Mayer IgA Nephropathy Laboratories, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Clin J Am Soc Nephrol
July 2024
John Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, United Kingdom.
JAMA Netw Open
June 2024
Division of Pediatric Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
J Hosp Infect
August 2024
Pharmacy Department, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Background: Intravenous (IV) antibiotic use in secondary care in England is widespread. Timely appropriate intravenous to oral switch (IVOS) has the potential to deliver significant clinical and operational benefits. To date, antimicrobial stewardship (AMS) efforts around IVOS have not focused on the nursing staff who administer antibiotics, which represents a significant gap in AMS programmes.
View Article and Find Full Text PDFJCO Precis Oncol
April 2024
Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Purpose: Here, we report the sensitivity of a personalized, tumor-informed circulating tumor DNA (ctDNA) assay (Signatera) for detection of molecular relapse during long-term follow-up of patients with breast cancer.
Methods: A total of 156 patients with primary breast cancer were monitored clinically for up to 12 years after surgery and adjuvant chemotherapy. Semiannual blood samples were prospectively collected, and analyzed retrospectively to detect residual disease by ultradeep sequencing using ctDNA assays, developed from primary tumor whole-exome sequencing data.
Int J Surg Pathol
December 2024
Department of Pathology and Laboratory Medicine, Western University and London Health Sciences Centre, London, Canada.
The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in interpreting mitotic figures among pathologists. This study leverages publicly accessible datasets and social media to recruit an international group of pathologists to score an image database of more than 1000 mitotic figures collectively.
View Article and Find Full Text PDFClin Res Cardiol
April 2024
Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands.
Background: Transcatheter aortic valve implantation (TAVI) serves a growing range of patients with severe aortic stenosis (AS). TAVI has evolved to a streamlined procedure minimizing length of hospital stay.
Aims: To evaluate the safety and efficacy of an early discharge (ED) strategy after TAVI.
Diabetes Ther
May 2024
Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, Clinical Sciences Centre, Aintree University Hospital, University of Liverpool, Liverpool, UK.
Vision (Basel)
March 2024
Stoneygate Eye Hospital, Leicester LE1 2EG, UK.
: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch's membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition.
View Article and Find Full Text PDFKidney Int
April 2024
John Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK; Mayer IgA Nephropathy Laboratories, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. Electronic address:
Advancements in glomerular transcriptomics offer a promising avenue toward precision medicine in IgA nephropathy. Traditional prognostic biomarkers, including proteinuria, blood pressure, and histomorphometry, fall short at capturing the complexity of IgA nephropathy and can only crudely guide therapeutic decisions. This issue needs to be addressed urgently as pathway-specific treatments become available.
View Article and Find Full Text PDFBr J Oral Maxillofac Surg
February 2024
Honorary Professor of Surgery, Consultant Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, United Kingdom. Electronic address:
J Nephrol
April 2024
Department of Cardiovascular Sciences, University of Leicester, Leicester, LE1 9HN, UK.
Patients with end-stage kidney disease (ESKD) have a high symptom-burden and high rates of morbidity and mortality. Despite this, evidence has shown that this patient group does not have timely discussions to plan for deterioration and death, and at the end of life there are unmet palliative care needs. Advance care planning is a process that can help patients share their personal values and preferences for their future care and prepare for declining health.
View Article and Find Full Text PDFBr J Haematol
January 2024
Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.